H.
BTEC L3 EXTENDED DIPLOMA IN APPLIED SCIENCE
Unit 4: Laboratory Techniques and their
Application
Assignment 4C: Explore manufacturing techniques and
testing methods for an organic solid
Aim
The aim of this experiment is to prepare and synthesise aspirin using salicylic
acid (limiting reactant) and ethanoic anhydride with the addition of a catalyst
(sulfuric acid). In this experiment the following reaction will occur to produce
aspirin:
HOOCC6H4OH + (CH3CO)2O ® HOOCC6H4OCOCH3 + CH3COOH
salicylic acid ethanoic aspirin ethanoic
anhydride acid
In addition to this, the purity of aspirin will be tested using different methods in
the laboratory and from carrying out these tests, a conclusion can be drawn
about the purity of aspirin.
Laboratory manufacture of aspirin
Part 1 – preparation of aspirin
Equipment list
- Salicylic acid
- Ethanoic anhydride
- Weighing scale
- Weighing boat
- Spatula
- 100cm3 conical flask
- 10cm3 measuring cylinder
- Stirring rod
- Pipette
- Distilled water
- Concentrated phosphoric acid
- Buchner filter paper and vacuum
- Water pump
- 250cm3 beaker
- 400cm3 beaker
- 100˚C thermometer
Risk assessment
Hazardous Nature of Source(s) Control Emergency
chemical/microorgan hazard(s) of measures procedure
ism being used or informati to reduce
made/hazardous on the risks
procedure or
equipment
1
, H.
BTEC L3 EXTENDED DIPLOMA IN APPLIED SCIENCE
Unit 4: Laboratory Techniques and their
Application
1) Salicylic acid 1) (a) Corrosive 1) 1) (a) Wear 1) (a) If eye
and an irritant, CLEAPSS eye irritation
can cause Student protection occurs,
serious eye Safety to avoid flood eyes
damage if Sheets contact with cold
come into with eyes water and
contact with (b) Ensure seek
eyes room is medical
(b) Can cause kept assistance
respiratory ventilated if
infection throughout necessary
(c) Harmful if experiment (b) Seek
swallowed or use a medical
fume advice
cupboard (c) If
(c) Keep swallowed,
away from rinse
mouth mouth with
water and
seek
medical
advice
2) Ethanoic 2) (a) 2) 2) (a) Wear 2) (a) If any
anhydride Liquid/vapour is CLEAPSS eye fires occur,
flammable Student protection cover with
(b) Harmful if Safety (b) Keep a fire
inhaled/swallow Sheets away from blanket/he
ed mouth at-resistant
(c) Can cause (c) Ensure mat
respiratory room is (b) If
irritation kept swallowed,
(d) Corrosive, ventilated rinse
can cause throughout mouth with
severe skin/eye experiment water and
damage or use a seek
fume medical
cupboard advice
(d) Wear (c) Ensure
eye room is
protection kept
and ventilated
protective throughout
gloves to experiment
avoid or use a
contact fume
with skin cupboard
(d) If come
into
contact
with
skin/eyes,
2
BTEC L3 EXTENDED DIPLOMA IN APPLIED SCIENCE
Unit 4: Laboratory Techniques and their
Application
Assignment 4C: Explore manufacturing techniques and
testing methods for an organic solid
Aim
The aim of this experiment is to prepare and synthesise aspirin using salicylic
acid (limiting reactant) and ethanoic anhydride with the addition of a catalyst
(sulfuric acid). In this experiment the following reaction will occur to produce
aspirin:
HOOCC6H4OH + (CH3CO)2O ® HOOCC6H4OCOCH3 + CH3COOH
salicylic acid ethanoic aspirin ethanoic
anhydride acid
In addition to this, the purity of aspirin will be tested using different methods in
the laboratory and from carrying out these tests, a conclusion can be drawn
about the purity of aspirin.
Laboratory manufacture of aspirin
Part 1 – preparation of aspirin
Equipment list
- Salicylic acid
- Ethanoic anhydride
- Weighing scale
- Weighing boat
- Spatula
- 100cm3 conical flask
- 10cm3 measuring cylinder
- Stirring rod
- Pipette
- Distilled water
- Concentrated phosphoric acid
- Buchner filter paper and vacuum
- Water pump
- 250cm3 beaker
- 400cm3 beaker
- 100˚C thermometer
Risk assessment
Hazardous Nature of Source(s) Control Emergency
chemical/microorgan hazard(s) of measures procedure
ism being used or informati to reduce
made/hazardous on the risks
procedure or
equipment
1
, H.
BTEC L3 EXTENDED DIPLOMA IN APPLIED SCIENCE
Unit 4: Laboratory Techniques and their
Application
1) Salicylic acid 1) (a) Corrosive 1) 1) (a) Wear 1) (a) If eye
and an irritant, CLEAPSS eye irritation
can cause Student protection occurs,
serious eye Safety to avoid flood eyes
damage if Sheets contact with cold
come into with eyes water and
contact with (b) Ensure seek
eyes room is medical
(b) Can cause kept assistance
respiratory ventilated if
infection throughout necessary
(c) Harmful if experiment (b) Seek
swallowed or use a medical
fume advice
cupboard (c) If
(c) Keep swallowed,
away from rinse
mouth mouth with
water and
seek
medical
advice
2) Ethanoic 2) (a) 2) 2) (a) Wear 2) (a) If any
anhydride Liquid/vapour is CLEAPSS eye fires occur,
flammable Student protection cover with
(b) Harmful if Safety (b) Keep a fire
inhaled/swallow Sheets away from blanket/he
ed mouth at-resistant
(c) Can cause (c) Ensure mat
respiratory room is (b) If
irritation kept swallowed,
(d) Corrosive, ventilated rinse
can cause throughout mouth with
severe skin/eye experiment water and
damage or use a seek
fume medical
cupboard advice
(d) Wear (c) Ensure
eye room is
protection kept
and ventilated
protective throughout
gloves to experiment
avoid or use a
contact fume
with skin cupboard
(d) If come
into
contact
with
skin/eyes,
2
