NAPLEX 2026 Top 200 Drugs &
Calculations Master Sheet 2026/2027 –
Complete Exam-Style Questions | 100%
Verified | Detailed Rationales – Pass
Guaranteed – A+ Graded
Part 1: Top 200 Drugs – High-Yield Quick Reference (Most Tested Classes)
Key
Generic Brand Class Counseling /
Black Box
No routine
DOAC (Factor monitoring;
Apixaban Eliquis
Xa inhibitor) antidote
andexanet alfa
Take with food
Rivaroxaban Xarelto DOAC
(15/20 mg)
INR 2-3; avoid
Vitamin K green leafy
Warfarin Coumadin
antagonist veggies
(vitamin K)
SC; monitor
Enoxaparin Lovenox LMWH anti-Xa in renal
impairment
, Key
Generic Brand Class Counseling /
Black Box
CYP2C19;
P2Y12
Clopidogrel Plavix prodrug; GI
inhibitor
bleed risk
HMG-CoA
reductase;
Atorvastatin Lipitor Statin myopathy,
hepatotoxicity;
take evening
Least CYP
Rosuvastatin Crestor Statin
interactions
Avoid
grapefruit; DDI
Simvastatin Zocor Statin with
amlodipine,
diltiazem
Edema,
headache; no
Amlodipine Norvasc DHP CCB
grapefruit
interaction
Bradycardia,
Lopressor/Topr Beta-1
Metoprolol masks
ol selective
hypoglycemia
Cough,
Lisinopril Prinivil/Zestril ACE inhibitor angioedema,
hyperkalemia;
, Key
Generic Brand Class Counseling /
Black Box
avoid
pregnancy
Same as ACE
Losartan Cozaar ARB
but no cough
Hypokalemia,
Hydrochlorothiazide Microzide Thiazide hyperglycemia,
photosensitivity
Ototoxicity,
hypokalemia;
Furosemide Lasix Loop diuretic sulfa allergy
cross-react?
(weak)
Gynecomastia,
Spironolactone Aldactone K+-sparing
hyperkalemia
GI upset; hold
for contrast
Metformin Glucophage Biguanide
(48h) – lactic
acidosis risk
Hypoglycemia,
Glipizide Glucotrol Sulfonylurea
weight gain
Long-acting No peak, once
Insulin glargine Lantus
insulin daily
, Key
Generic Brand Class Counseling /
Black Box
Take fasting
Thyroid 30-60 min
Levothyroxine Synthroid
hormone before food;
same time daily
Tremor,
tachycardia;
Albuterol ProAir/Ventolin SABA
not for long-
term control
Rinse mouth
Fluticasone/salmetero
Advair ICS/LABA after use
l
(thrush)
Aminopenicilli Diarrhea, rash
Amoxicillin –
n (non-allergic)
Cross-allergy
1st gen
Cephalexin Keflex with PCN
cephalosporin
~10%
QTc
prolongation;
Azithromycin Zithromax Macrolide take 1h before
or 2h after
antacids
Photosensitivit
y; avoid
Doxycycline Vibramycin Tetracycline
dairy/antacids
(chelation)
Calculations Master Sheet 2026/2027 –
Complete Exam-Style Questions | 100%
Verified | Detailed Rationales – Pass
Guaranteed – A+ Graded
Part 1: Top 200 Drugs – High-Yield Quick Reference (Most Tested Classes)
Key
Generic Brand Class Counseling /
Black Box
No routine
DOAC (Factor monitoring;
Apixaban Eliquis
Xa inhibitor) antidote
andexanet alfa
Take with food
Rivaroxaban Xarelto DOAC
(15/20 mg)
INR 2-3; avoid
Vitamin K green leafy
Warfarin Coumadin
antagonist veggies
(vitamin K)
SC; monitor
Enoxaparin Lovenox LMWH anti-Xa in renal
impairment
, Key
Generic Brand Class Counseling /
Black Box
CYP2C19;
P2Y12
Clopidogrel Plavix prodrug; GI
inhibitor
bleed risk
HMG-CoA
reductase;
Atorvastatin Lipitor Statin myopathy,
hepatotoxicity;
take evening
Least CYP
Rosuvastatin Crestor Statin
interactions
Avoid
grapefruit; DDI
Simvastatin Zocor Statin with
amlodipine,
diltiazem
Edema,
headache; no
Amlodipine Norvasc DHP CCB
grapefruit
interaction
Bradycardia,
Lopressor/Topr Beta-1
Metoprolol masks
ol selective
hypoglycemia
Cough,
Lisinopril Prinivil/Zestril ACE inhibitor angioedema,
hyperkalemia;
, Key
Generic Brand Class Counseling /
Black Box
avoid
pregnancy
Same as ACE
Losartan Cozaar ARB
but no cough
Hypokalemia,
Hydrochlorothiazide Microzide Thiazide hyperglycemia,
photosensitivity
Ototoxicity,
hypokalemia;
Furosemide Lasix Loop diuretic sulfa allergy
cross-react?
(weak)
Gynecomastia,
Spironolactone Aldactone K+-sparing
hyperkalemia
GI upset; hold
for contrast
Metformin Glucophage Biguanide
(48h) – lactic
acidosis risk
Hypoglycemia,
Glipizide Glucotrol Sulfonylurea
weight gain
Long-acting No peak, once
Insulin glargine Lantus
insulin daily
, Key
Generic Brand Class Counseling /
Black Box
Take fasting
Thyroid 30-60 min
Levothyroxine Synthroid
hormone before food;
same time daily
Tremor,
tachycardia;
Albuterol ProAir/Ventolin SABA
not for long-
term control
Rinse mouth
Fluticasone/salmetero
Advair ICS/LABA after use
l
(thrush)
Aminopenicilli Diarrhea, rash
Amoxicillin –
n (non-allergic)
Cross-allergy
1st gen
Cephalexin Keflex with PCN
cephalosporin
~10%
QTc
prolongation;
Azithromycin Zithromax Macrolide take 1h before
or 2h after
antacids
Photosensitivit
y; avoid
Doxycycline Vibramycin Tetracycline
dairy/antacids
(chelation)
