_______________ is determined by the blood flow to tissues, the ability of a drug to exit the
vascular system, and to a lesser extent the ability of a drug to enter cells
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distribution
Drugs that decrease the rate of drug metabolism
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inhibitors
What is the purpose of genetic testing?
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- Genetic testing is recommended to identify how a patient will respond to
a drug and not to design a drug specific to an individual.
Definition of Schedule 2 drugs. Can you provide an example?
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High abuse potential w/ severe psychic or physical dependence liability.
Consists of certain narcotic, stimulant and depressant drugs: Opium,
Morphine, Codeine, Dilaudid, methadone, Demerol, hydrocodone,
methylphenidate
What factors contribute to medication errors? How can a provider minimize the risk
for medication errors?
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- Prescribing practices
- Error in drug dosage
- Lack of clear labeling instructions
- Illegible writing
- Oversight- failure to keep up-to-date medication list
- Failure to continue/discontinue medications
- Absence of medication reconciliation
- Communication- inadequate or unclear instructions
- Inadequate patient education
, What happens when a patient takes a drug that is metabolized by P450 enzymes if an
inducing OR an inhibiting drug is added to the current drug regimen?
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- Drugs that are metabolized by P450 are substrates
- A drug that acts as an inducing agent for an enzyme system increases the
metabolism of drugs metabolized by that enzyme system, thereby lowering
the level of those drugs in the body and requiring higher doses to maintain
drug effectiveness. Although decreasing the dosage of the drug that
induces metabolism may seem reasonable at first glance, this may decrease
the therapeutic level of the drug making it ineffective in treating the
condition for which it was prescribed.
For example, if a woman taking oral contraceptives were to begin taking
phenobarbital, induction of drug metabolism by phenobarbital would
accelerate metabolism of the contraceptive, thereby lowering its level. If
drug metabolism were increased enough, protection against pregnancy
would be lost.
T/F: It is possible for two formulations of the same drug to be chemically equivalent
while differing in bioavailability.
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True
This is why one brand of one drug may work faster or slower than another
brand of the same drug. The inactive ingredients used by drug companies
are called binders and fillers....these ingredients can dissolve at different
rates affecting the bioavailability of the drug.
vascular system, and to a lesser extent the ability of a drug to enter cells
Give this one a try later!
distribution
Drugs that decrease the rate of drug metabolism
Give this one a try later!
inhibitors
What is the purpose of genetic testing?
,Give this one a try later!
- Genetic testing is recommended to identify how a patient will respond to
a drug and not to design a drug specific to an individual.
Definition of Schedule 2 drugs. Can you provide an example?
Give this one a try later!
High abuse potential w/ severe psychic or physical dependence liability.
Consists of certain narcotic, stimulant and depressant drugs: Opium,
Morphine, Codeine, Dilaudid, methadone, Demerol, hydrocodone,
methylphenidate
What factors contribute to medication errors? How can a provider minimize the risk
for medication errors?
Give this one a try later!
- Prescribing practices
- Error in drug dosage
- Lack of clear labeling instructions
- Illegible writing
- Oversight- failure to keep up-to-date medication list
- Failure to continue/discontinue medications
- Absence of medication reconciliation
- Communication- inadequate or unclear instructions
- Inadequate patient education
, What happens when a patient takes a drug that is metabolized by P450 enzymes if an
inducing OR an inhibiting drug is added to the current drug regimen?
Give this one a try later!
- Drugs that are metabolized by P450 are substrates
- A drug that acts as an inducing agent for an enzyme system increases the
metabolism of drugs metabolized by that enzyme system, thereby lowering
the level of those drugs in the body and requiring higher doses to maintain
drug effectiveness. Although decreasing the dosage of the drug that
induces metabolism may seem reasonable at first glance, this may decrease
the therapeutic level of the drug making it ineffective in treating the
condition for which it was prescribed.
For example, if a woman taking oral contraceptives were to begin taking
phenobarbital, induction of drug metabolism by phenobarbital would
accelerate metabolism of the contraceptive, thereby lowering its level. If
drug metabolism were increased enough, protection against pregnancy
would be lost.
T/F: It is possible for two formulations of the same drug to be chemically equivalent
while differing in bioavailability.
Give this one a try later!
True
This is why one brand of one drug may work faster or slower than another
brand of the same drug. The inactive ingredients used by drug companies
are called binders and fillers....these ingredients can dissolve at different
rates affecting the bioavailability of the drug.
