ASAM TEST QUESTIONS WITH VERIFIED ACCURATE
ANSWERS
mechanism of alcohol - Answers - NMDA antagonist
mechanism of opiate withdrawal - Answers - related to locus ceruleus
mechanism of alcohol withdrawal - Answers - Upregulation of the NMDA receptor
complex leading to neuronal hyperexcitability
C77G allele in rhesus monkeys that is analogous to the A118 G allele in humans
display what behavior? - Answers - drink more alcohol
receptor for benzodiazepine - Answers - GABA A
receptor for GHB - Answers - GABA B
receptor for baclofen - Answers - GABA B
ketamine mechanism of action - Answers - NMDA antagonist
endogenous ligand for cb2 receptor - Answers - anandamide
opioid tolerance mechanism - Answers - protein kinase c phosphorylation of opiate
receptors
The negative reinforcement theory of opioid dependence postulates a state of which of
the following in the neural system of the addict, leading to continued abuse of opioids -
Answers - allostasis
cocaine mechanism of action - Answers - inhibits presynaptic reuptake of dopamine
number of subunits in GABA A - Answers - 5
neurobiological pathway most likely involved in relapse in cocaine and meth
dependence - Answers - cingulate cortex to the nucleus accumbens
legal limit of alcohol for driving in mmol/L - Answers - 17
legal limit of alcohol for driving in mg/dL - Answers - 0.08
, caffeine consumption lowest among which population of substance dependent people -
Answers - cocaine
animal model for the subjective effects of drugs - Answers - drug discrimination
which addiction related drug has no effect on the cytochrome p450 system? - Answers -
chantix
location of CB1 - Answers - presynaptic in the CNS
rate of metabolism of alcohol - Answers - 0.015 mg/dL/hr or .02g/dL/he for heavy
drinker
neurotransmitter systems involved in alcohol - Answers - serotonin system, opioid
system, adenyl cyclase, cholinergic system
Acetaldehyde Dehydrogenase form that protects against alcohol dependence - Answers
- low activity isoform
Percentage heritability of alcohol dependence based on twin studies - Answers - 50-
60%
alcohol metabolite detected in hair - Answers - ethyl glucoronide
Cloninger Type 2 Alcoholics are characterized by - Answers - Drinking in youth, often
before age 12
Cloninger Type 1 Alcoholics are characterized by - Answers - Gradual onset, harm
avoidance, reward dependency, and liver failure at age 50
Gastrointestinal absorption of alcohol occurs where? - Answers - Primarily jejunum of
the small intestine
Chemical reaction metabolizing alcohol in the liver - Answers - oxidation
rate of metabolism of alcohol in ml/hour - Answers - 10mL/hour
typical findings in acute alcoholic myopathy - Answers - weakness, asymmetric swelling,
involvement of proximal muscles. NOT fever.
sleep problems from alcohol persist up to - Answers - 18 months
alcohol related birth defects - Answers - microcephaly, small palpebral fissures, flat
philtrum, flat nose
ANSWERS
mechanism of alcohol - Answers - NMDA antagonist
mechanism of opiate withdrawal - Answers - related to locus ceruleus
mechanism of alcohol withdrawal - Answers - Upregulation of the NMDA receptor
complex leading to neuronal hyperexcitability
C77G allele in rhesus monkeys that is analogous to the A118 G allele in humans
display what behavior? - Answers - drink more alcohol
receptor for benzodiazepine - Answers - GABA A
receptor for GHB - Answers - GABA B
receptor for baclofen - Answers - GABA B
ketamine mechanism of action - Answers - NMDA antagonist
endogenous ligand for cb2 receptor - Answers - anandamide
opioid tolerance mechanism - Answers - protein kinase c phosphorylation of opiate
receptors
The negative reinforcement theory of opioid dependence postulates a state of which of
the following in the neural system of the addict, leading to continued abuse of opioids -
Answers - allostasis
cocaine mechanism of action - Answers - inhibits presynaptic reuptake of dopamine
number of subunits in GABA A - Answers - 5
neurobiological pathway most likely involved in relapse in cocaine and meth
dependence - Answers - cingulate cortex to the nucleus accumbens
legal limit of alcohol for driving in mmol/L - Answers - 17
legal limit of alcohol for driving in mg/dL - Answers - 0.08
, caffeine consumption lowest among which population of substance dependent people -
Answers - cocaine
animal model for the subjective effects of drugs - Answers - drug discrimination
which addiction related drug has no effect on the cytochrome p450 system? - Answers -
chantix
location of CB1 - Answers - presynaptic in the CNS
rate of metabolism of alcohol - Answers - 0.015 mg/dL/hr or .02g/dL/he for heavy
drinker
neurotransmitter systems involved in alcohol - Answers - serotonin system, opioid
system, adenyl cyclase, cholinergic system
Acetaldehyde Dehydrogenase form that protects against alcohol dependence - Answers
- low activity isoform
Percentage heritability of alcohol dependence based on twin studies - Answers - 50-
60%
alcohol metabolite detected in hair - Answers - ethyl glucoronide
Cloninger Type 2 Alcoholics are characterized by - Answers - Drinking in youth, often
before age 12
Cloninger Type 1 Alcoholics are characterized by - Answers - Gradual onset, harm
avoidance, reward dependency, and liver failure at age 50
Gastrointestinal absorption of alcohol occurs where? - Answers - Primarily jejunum of
the small intestine
Chemical reaction metabolizing alcohol in the liver - Answers - oxidation
rate of metabolism of alcohol in ml/hour - Answers - 10mL/hour
typical findings in acute alcoholic myopathy - Answers - weakness, asymmetric swelling,
involvement of proximal muscles. NOT fever.
sleep problems from alcohol persist up to - Answers - 18 months
alcohol related birth defects - Answers - microcephaly, small palpebral fissures, flat
philtrum, flat nose
