ADVANCED PHARMACOLOGY
COMPREHENSIVE EXAMINATION TEST
2026 QUESTIONS AND SOLUTIONS
GRADED A+
◉ What does a low level of thyroid-stimulating hormone indicate?
Answer: Hyperthroidism
◉ What would be the best option to treat a newly diagnosed patient
with a low TSH level with?
Answer: Propanolol (Inderal)
◉ Spironoaldactone (Aldactone) has what mechanism of action
(MOA)?
Answer: Aldosterone antagonist
◉ Heparin exerts its therapeutic action by what?
Answer: Upregulating the activity of one of the body's natural
anticoagulant molecules, antithrombin III
◉ What physiologic action happens when the offending drug is
administered during an anaphylactic reaction.
,Answer: Mast cells liberate large doses of histamine.
◉ What are two systemic psoriasis medications?
Answer: Photo-therapy and topical corticosteroids
◉ What is the first choice of drug therapy for the majority of
patients with uncomplicated stage I hypertension?
Answer: Thiazide diuretics
◉ What is the effect of cardiac glycosides?
Answer: Digitalis glycosides have a negative chronotropic effect on
the cardiac muscle cells.
◉ Amenorrhea is the most common side effect of which birth
control medication?
Answer: Medroxyprogesterone (Depo-Provera)
◉ What is an anti-hypertensive agent which competes with
epinephrine for available beta-receptor sites?
Answer: Atenolol (Tenormin)
◉ What type of action does nitrates have on the body?
Answer: Reduction in systemic venous tone.
, ◉ What is the recommended level of low-density lipoprotein
cholesterol (LDL) for patients with known coronary artery disease?
Answer: 100mg/dl or less.
◉ What is the MOA of group IV anti-dysrhythmia drugs?
Answer: Depressing phase 4 depolarization and lengthening phases
1 and 2 repolarization.
◉ Which drug therapy should be used to lower the serum
concentration of thyroid hormones and re-establish eumetabolic
state in a patient with Graves' disease?
Answer: Anti-thyroid drugs.
◉ Which type of diuretic would be used for a stage I hypertension in
a patient with renal insufficiency?
Answer: Loop diuretic.
◉ What drug should be considered as first-line therapy for a client
with hypertension and heart failure?
Answer: Enalapril (Vasotec)
◉ Which drug is considered safe for hypertension treatment during
pregnancy?
COMPREHENSIVE EXAMINATION TEST
2026 QUESTIONS AND SOLUTIONS
GRADED A+
◉ What does a low level of thyroid-stimulating hormone indicate?
Answer: Hyperthroidism
◉ What would be the best option to treat a newly diagnosed patient
with a low TSH level with?
Answer: Propanolol (Inderal)
◉ Spironoaldactone (Aldactone) has what mechanism of action
(MOA)?
Answer: Aldosterone antagonist
◉ Heparin exerts its therapeutic action by what?
Answer: Upregulating the activity of one of the body's natural
anticoagulant molecules, antithrombin III
◉ What physiologic action happens when the offending drug is
administered during an anaphylactic reaction.
,Answer: Mast cells liberate large doses of histamine.
◉ What are two systemic psoriasis medications?
Answer: Photo-therapy and topical corticosteroids
◉ What is the first choice of drug therapy for the majority of
patients with uncomplicated stage I hypertension?
Answer: Thiazide diuretics
◉ What is the effect of cardiac glycosides?
Answer: Digitalis glycosides have a negative chronotropic effect on
the cardiac muscle cells.
◉ Amenorrhea is the most common side effect of which birth
control medication?
Answer: Medroxyprogesterone (Depo-Provera)
◉ What is an anti-hypertensive agent which competes with
epinephrine for available beta-receptor sites?
Answer: Atenolol (Tenormin)
◉ What type of action does nitrates have on the body?
Answer: Reduction in systemic venous tone.
, ◉ What is the recommended level of low-density lipoprotein
cholesterol (LDL) for patients with known coronary artery disease?
Answer: 100mg/dl or less.
◉ What is the MOA of group IV anti-dysrhythmia drugs?
Answer: Depressing phase 4 depolarization and lengthening phases
1 and 2 repolarization.
◉ Which drug therapy should be used to lower the serum
concentration of thyroid hormones and re-establish eumetabolic
state in a patient with Graves' disease?
Answer: Anti-thyroid drugs.
◉ Which type of diuretic would be used for a stage I hypertension in
a patient with renal insufficiency?
Answer: Loop diuretic.
◉ What drug should be considered as first-line therapy for a client
with hypertension and heart failure?
Answer: Enalapril (Vasotec)
◉ Which drug is considered safe for hypertension treatment during
pregnancy?
