MSN 671 Module 3 Exam UPDATED ACTUAL QUESTIONS AND CORRECT ANSWERS

MSN 671 Module 3 Exam UPDATED ACTUAL
QUESTIONS AND CORRECT ANSWERS
Ligand-gated ion channels - CORRECT ANSWER Activated by the binding of a
neurotransmitter, drug, or hormone.



Voltage-sensitive ion channels - CORRECT ANSWER Activated by changes in
membrane voltage or charge.



Ionotropic receptors - CORRECT ANSWER Another name for ligand-gated ion
channels.


Clinical relevance of ligand-gated vs voltage-sensitive channels - CORRECT
ANSWER LGICs → rapid effects (e.g., benzodiazepines, ketamine); VSSCs/VSCCs
→ anticonvulsants, mood stabilizers, analgesics.



Dual role of ligand-gated ion channels - CORRECT ANSWER They act as both
receptors and ion channels.



Structure of LGICs - CORRECT ANSWER Several subunits arranged around an ion
channel with binding sites for NTs, drugs, ions, and allosteric modulators.



Pentameric receptors - CORRECT ANSWER Receptors with 5 subunits.



Tetrameric receptors - CORRECT ANSWER Receptors with 4 subunits + re-entrant
loop.



Examples of pentameric receptors - CORRECT ANSWER GABAA_AA, Nicotinic
acetylcholine receptor (nAChR), 5-HT3, Glycine receptor.



Examples of tetrameric receptors - CORRECT ANSWER AMPA, NMDA, Kainate
(glutamate receptors).