Class Prototype Mechanism of Clinical Pearl
Action
Muscarinic Bethanechol Stimulates M Contraindicated in
Agonist receptors Asthma(bronchoconstriction)
(SLUDGE)
Antimuscarinic Atropine Blocks M Used for Organophosphate
receptors poisoning & bradycardia
(Anti-SLUDGE)
AChE Inhibitor Neostigmine Prevents ACh Reverses non-depolarizing
breakdown NMBs
Depolarizing NMB Succinylcholine Persistent NMJ Risk of Malignant
depolarization Hyperthermia & hyper K+
alpha_1Agonist Phenylephrine Vasoconstriction Risk of reflex bradycardia
($\uparrow$SVR)
beta_2 Agonist Albuterol Bronchodilation Rescue inhaler; watch for
tachycardia/tremor
II. Anti-Inflammatory & Analgesics
● NSAIDs (Ibuprofen/Naproxen): Inhibit COX-1 and COX-2 to reduce prostaglandins.
Risk of GI bleeds and Renal AKI.
● Aspirin: Irreversibly inhibits COX-1 (antiplatelet). High risk of Reye’s Syndrome in
children with viral infections.
● Acetaminophen (APAP): Analgesic/antipyretic with NO anti-inflammatory activity.
Antidote for overdose is N-acetylcysteine (NAC).
Action
Muscarinic Bethanechol Stimulates M Contraindicated in
Agonist receptors Asthma(bronchoconstriction)
(SLUDGE)
Antimuscarinic Atropine Blocks M Used for Organophosphate
receptors poisoning & bradycardia
(Anti-SLUDGE)
AChE Inhibitor Neostigmine Prevents ACh Reverses non-depolarizing
breakdown NMBs
Depolarizing NMB Succinylcholine Persistent NMJ Risk of Malignant
depolarization Hyperthermia & hyper K+
alpha_1Agonist Phenylephrine Vasoconstriction Risk of reflex bradycardia
($\uparrow$SVR)
beta_2 Agonist Albuterol Bronchodilation Rescue inhaler; watch for
tachycardia/tremor
II. Anti-Inflammatory & Analgesics
● NSAIDs (Ibuprofen/Naproxen): Inhibit COX-1 and COX-2 to reduce prostaglandins.
Risk of GI bleeds and Renal AKI.
● Aspirin: Irreversibly inhibits COX-1 (antiplatelet). High risk of Reye’s Syndrome in
children with viral infections.
● Acetaminophen (APAP): Analgesic/antipyretic with NO anti-inflammatory activity.
Antidote for overdose is N-acetylcysteine (NAC).
