USMLE Step 1 Rapid Review – Complete Exam Study Guide 2026/2027 with Verified Answers | Newest Version. A+

USMLE Step 1 Rapid Review

abdominal pain, ascites, hepatomegaly ------- ✔ CORRECT ANSWER ✓✓Budd-Chiari syndrome



Familial hypercholesterolemia ------- ✔ CORRECT ANSWER ✓✓achilles tendon xanthoma



adrenal hemorrhage, hypotension, DIC ------- ✔ CORRECT ANSWER ✓✓Waterhouse-
Friderichsen syndrome



biochemistry of Marfan's syndrome ------- ✔ CORRECT ANSWER ✓✓fibrillin defect



posthepatic venous thrombosis ------- ✔ CORRECT ANSWER ✓✓Budd-Chiari syndrome



Familial hypercholesterolemia biochemistry ------- ✔ CORRECT ANSWER ✓✓decrease in LDL
receptor signaling



Waterhouse-Friderichsen syndrome cause ------- ✔ CORRECT ANSWER ✓✓meningococcemia



arachnodactyly, lens dislocation, aortic dissection, hyperflexible joints ------- ✔ CORRECT
ANSWER ✓✓Marfan's syndrome



Athlete with polycythemia ------- ✔ CORRECT ANSWER ✓✓EPO injection



Pott's disease ------- ✔ CORRECT ANSWER ✓✓vertebral TB

, Pott's disease clinical presentation ------- ✔ CORRECT ANSWER ✓✓back pain, fever, night
sweats, weight loss



Sarcoidosis main histological presentation ------- ✔ CORRECT ANSWER ✓✓noncaseating
granuloma



bilateral hilar adenopathy + uveitis ------- ✔ CORRECT ANSWER ✓✓sarcoidosis



Osteogenesis imperfecta ------- ✔ CORRECT ANSWER ✓✓type I collagen defect



Blue sclera indicate what? ------- ✔ CORRECT ANSWER ✓✓osteogenesis imperfecta



Burton's line indicates what? ------- ✔ CORRECT ANSWER ✓✓lead poisoning



Burton's line ------- ✔ CORRECT ANSWER ✓✓bluish line on gingiva



Paget's disease of the bone biochemistry ------- ✔ CORRECT ANSWER ✓✓increase in
osteoblastic and osteoclastic activity



bone pain, bone enlargement, arthritis ------- ✔ CORRECT ANSWER ✓✓Paget's disease of the
bone



bounding pulses, diastolic heart murmur, head bobbing ------- ✔ CORRECT ANSWER ✓✓aortic
regurgitation



butterfly facial rash, Raynaud's phenomenon in a young female ------- ✔ CORRECT ANSWER
✓✓SLE

,Neurofibromatosis type I associated with what malignancies ------- ✔ CORRECT ANSWER
✓✓pheochromocytoma, optic gliomas



cafe-au-lait spots and Lisch nodules ------- ✔ CORRECT ANSWER ✓✓Neurofibromatosis type I



Lisch nodules ------- ✔ CORRECT ANSWER ✓✓iris hemartoma



McCune-Albright syndrome biochemistry ------- ✔ CORRECT ANSWER ✓✓mosaic continuous
activation of stimulatory G protein



cafe-au-lait spots, polyostotic fibrous dysplasia, precocious puberty, multiple endocrine
abnormalities ------- ✔ CORRECT ANSWER ✓✓McCune-Albright syndrome



Duchenne's muscular dystrophy ------- ✔ CORRECT ANSWER ✓✓X-linked recessive deletion of
dystrophin gene



Calf pseduohypertrophy ------- ✔ CORRECT ANSWER ✓✓Duchenne's muscular dystrophy



clinical sign of Tay-Sach's, Niemann-Pick, or central retinal artery occlusion ------- ✔ CORRECT
ANSWER ✓✓Cherry-red spot on macula



ganglioside accumulation ------- ✔ CORRECT ANSWER ✓✓Tay-Sach's



sphingomyelin accumulation ------- ✔ CORRECT ANSWER ✓✓Niemann-Pick disease



Stable angina ------- ✔ CORRECT ANSWER ✓✓with moderate exercise

, Unstable angina ------- ✔ CORRECT ANSWER ✓✓with minimal exertion



Angina ------- ✔ CORRECT ANSWER ✓✓chest pain on exertion



autoimmune-mediated post-MI fibrinous pericarditis 1-12 weeks after acute episode ------- ✔
CORRECT ANSWER ✓✓Dressler syndrome



Chest pain, pericardial effusion, friction rub, persistent fever following MI 1-12 weeks after ------
- ✔ CORRECT ANSWER ✓✓Dressler's syndrome



Gowers' sign associated with what disease? ------- ✔ CORRECT ANSWER ✓✓Duchenne muscular
dystrophy



Gower's sign definition ------- ✔ CORRECT ANSWER ✓✓child uses arms to stand up from squat



"Slapped cheeks" ------- ✔ CORRECT ANSWER ✓✓erythema infectiosum/fifth disease



Erythema infectiosum/fifth disease ------- ✔ CORRECT ANSWER ✓✓parvovirus B19



child with fever later develops red rash on face that spreads to body ------- ✔ CORRECT ANSWER
✓✓erythema infectiosum/fifth disease



autosomal-dominant CAG repeat expansion ------- ✔ CORRECT ANSWER ✓✓Huntington's
disease



chorea, dementia, caudate degeneration ------- ✔ CORRECT ANSWER ✓✓Huntington's disease