Corticosteroids

learning objectives



· draw a diagram that outlines the roles of the hypothalamic pituitary adrenal axis (MPA axis) in regulation of endogenous cortisteroid hormones.


· describe molecular mechanism of glucocorticoid action



· how does this mechanism enable immunosuppressive and anti-inflammatory action of glucocorticoids

examples of unwanted effects of glucocorticoid therapy , including clinical manifestation




What are corticosteroid hormones ?




form of steroid hormone ,
derived from cholesterol



Cholesterol -
important synthetic precursor for any steroid hormone


cortisol >
-
important constituent for normal physiological
↓

function by both groups of these hormones steroid hormone


-
Corticosteroid hormone sexhormones -
2 categories
I Y

glucocorticoids+ eg.Cortisos
.
mineral corticoids - e g .
.
aldosterone
, hormone
Y
fluid balance




Corticosteroid hormones >
- a bunch of hormones that can have effects at one or two receptors or classes of receptors




What do
they do ?


X
medicinal form of cortisol> miniching physiological effect of endogenous compound

Cortisone inactive


precursor of cortisol


can convert both ways

Y can also be exploited for pharmacological action for anti-inflammatory and immunosuppressant uses.
Cortisol is active has



pharmacological effects
X lower adverse effects you need to lower potential mineralocorticoid activity




senteric
hormones
(
<
more selective