Beta blockers

Beta blockers




learning objectives


·
difference between sympathetic and parasympathetic ANS


mechanism of action of Beta blockers ->
> beta-1 and beta-2 adrenoreceptors

list cardiovascular conditions this drug can treat


↳ how the condition include adverse
they treat >
-
drug effects

·
Explain why adverse effect happen using mechanism of action




ANS




What are beta blockers ?




· GPCR


·
broadly alpha and beta adrenoreceptors

· beta blocker block beta adrenoreceptors they look similar

X
> can be non-selective
-
and also have antagonism on alpha adrenoreceptors




then activated
·
by catecholamine like adrenaline > -
beta adrenoreceptor stimulate adenyly-cyclase

ATP-> CAMP

-
heart muscle contraction smooth muscle relaxation glycogenolysis (glylogen -
> glucose)
, ,




Selectivity of beta-blockers




main ·
Beta1-mainly cardial


>
-
cardio selective drugs - e .

.
g bisoprolol