ACE inhibitors

learning outcomes



· Describe . A
M O.

Of ACE inhibitors and ARBs


· Clinical use of ACE inhibitors and ARBs


· side effects

both
·
compare and contrast the effects of drugs



Renin-Angiotensin-Aldosterone system




Angiotensin converting enzyme




·
Catalysing the conversion of Angl to Ang 11




· Breaks down bradykinin




ACE inhibitors




·
captopril >
-
heart failure


2nd line treatment
Ramipril >
hypertension (1st or
-
·




·
Enalapril -
prophylactic in ischaemic heart disease




side effect/intolerance




·
persistent dry cough > increased levels
-
of bradykinin sensitises airways




·
Angioedma >
-
increased levels of bradykin > increases
-
vascular permeability

more common for women and those of African descent