TEST BANKc
Cellular and Molecular Immunology
c c c
Abul Abbas, Andrew Lichtman, and Shiv Pillai
c c c c c c
10th Edition
c
PlusBay.Plus
,Table of Contents
c c
Chapterc01cPropertiescandcOverviewcofcImmunecResponses 1
Chapterc02cCellscandcTissuescofcthecImmunecSystem 3
Chapterc03cLeukocytecCirculationcandcMigrationcIntocTissues 6
Chapterc04cInnatecImmunity 10
Chapterc05cAntibodiescandcAntigens 17
Chapterc06cAntigencPresentationctocTcLymphocytescandcthecFunctionscofcMajor
HistocompatibilitycComplexcMolecules 20
Chapterc07cImmunecReceptorscandcSignalcTransduction 27
Chapterc08cLymphocytecDevelopmentcandcAntigencReceptorcGenecRearrangement 30
Chapterc09cActivationcofcTcLymphocytes 34
Chapterc10cDifferentiationcandcFunctionscofcCD4+cEffectorcTcCells 38
Chapterc11cDifferentiationcandcFunctionscofcCD8+cEffectorcTcCells 42
Chapterc12cBcCellcActivationcandcAntibodycProduction 46
Chapterc13cEffectorcMechanismscofcHumoralcImmunity 52
Chapterc14cSpecializedcImmunitycatcEpithelialcBarrierscandcincImmunecPrivilegedcTissues 56
Chapterc15cImmunologiccTolerancecandcAutoimmunity 62
Chapterc16cImmunityctocMicrobes 67
Chapterc17cTransplantationcImmunology 72
Chapterc18cTumorcImmunology 77
Chapterc19cHypersensitivitycDisorders 81
Chapterc20cAllergy 86
Chapterc21cPrimarycandcAcquiredcImmunodeficiencies 89
PlusBay.Plus
,Chapter 01: Properties and Overview of Immune Responses
c c c c c c c
Abbas, Lichtman, and Pillai: Cellular and Molecular Immunology, 10th Edition
c c c c c c c c c
MULTIPLEcCHOICE
1. Thecprincipalcfunctioncofcthecimmunecsystemcis:
a. Defensecagainstccancer
b. Repaircofcinjuredctissues
c. Defensecagainstcmicrobialcinfections
d. Preventioncofcinflammatorycdiseases
e. Protectioncagainstcenvironmentalctoxins
ANS:c c C
Thecimmunecsystemchascevolvedcincthecsettingcofcselectivecpressurescimposedcbycmicrobialcinfec
tions.cAlthoughcimmunecresponsesctoccancercmaycoccur,cthecconceptcthatc“immunosurveillance”c
againstccancerciscacprincipalcfunctioncofcthecimmunecsystemcisccontroversial.cRepaircofcinjuredctis
suescmaycbecacsecondarycconsequencecofcthecimmunecresponsescandcinflammation.cAlthoughcthec
immunecsystemchascregulatorycfeaturescthatcarecneededctocpreventcexcessivecinflammation,cprev
entioncofcinflammatorycdiseasesciscnotcacprimarycfunction.cThecimmunecsystemccancprotectcagain
stcmicrobialctoxins,cbutcitcgenerallycdoescnotcoffercprotectioncagainstctoxinscofcnonbiologiccorigin
.
2. Whichcofcthecfollowingcinfectiouscdiseasescwascpreventedcbycthecfirstcsuccessfulcv
accination?
a. Polio
b. Tuberculosis
c. Smallpox
d. Tetanus
e. Rubella
ANS:c c C
Inc1798,cEdwardcJennercreportedcthecfirstcintentionalcsuccessfulcvaccination,cwhichcwascagain
stcsmallpoxcincacboy,cusingcmaterialcfromctheccowpoxcpustulescofcacmilkmaid.cInc1980,csmallpo
xcwascreportedctocbeceradicatedcworldwidecbycacvaccinationcprogram.cEffectivecvaccinescagai
nstctetanusctoxin,crubellacvirus,candcpolioviruscwerecdevelopedcincthec20thccenturycandcarecwid
elycused.cThereciscnoceffectivecvaccinecagainstcMycobacteriumctuberculosis.
3. Whichcofcthecfollowingciscacuniquecpropertycofcthecadaptivecimmunecsystem?
a. Highlycdiversecrepertoirecofcspecificitiescforcantigens
b. Self-nonselfc discrimination
c. Recognitioncofcmicrobialcstructurescbycbothccell-associatedcandcsolublecreceptors
d. Protectioncagainstcviralcinfections
e. Responsescthatchavecthecsameckineticscandcmagnitudeconcrepeatedcexposurectocthecs
amecmicrobe
ANS:c c A
PlusBay.Plus
, HighlycdiversecrepertoirescofcspecificitiescforcantigenscarecfoundconlycincTcandcBclymphocytes
,cwhichcarectheccentralccellularccomponentscofcthecadaptivecimmunecsystem.cBothcthecinnatecan
dcthecadaptivecimmunecsystemscuseccell-
associatedcandcsolublecreceptorsctocrecognizecmicrobes,cdisplaycsomecdegreecofcself-
nonselfcdiscrimination,candcprotectcagainstcviruses.cOncrepeatedcexposurectocthecsamecmicrob
e,cthecadaptivecimmunecresponsecbecomescmorecrapidcandcofcgreatercmagnitude;cthisciscthecma
nifestationcofcmemory.
4. AntibodiescandcTclymphocytescarecthecrespectivecmediatorscofcwhichctwoctypescofci
mmunity?
a. Innatecandcadaptive
b. Passivecandcactive
c. Specificcandcnonspecific
d. Humoralcandccell-mediated
e. Adultcandcneonatal
ANS:c c D
BothcBcandcTclymphocytescarecprincipalccomponentscofcadaptivecimmunity.cBclymphocytescpr
oducecantibodies,cwhichcarecthecrecognitioncandceffectorcmoleculescofchumoralcimmunecrespo
nsesctocextracellularcpathogens.cTccellscrecognizecandcpromoteceradicationcofcintracellularcpath
ogenscinccell-
mediatedcimmunity.cPassivecandcactivecimmunitycbothccancbecmediatedcbyceithercBcorcTclymph
ocytes.cSpecificcimmunityciscanotherctermcforcadaptivecimmunity.cBothcBcandcTclymphocytescp
articipatecincadultcadaptivecimmunitycbutcarecstillcdevelopingcincthecneonatalcperiod.
5. ThectwocmajorcfunctionalcclassescofceffectorcTclymphocytescare:
a. HelpercTclymphocytescandccytotoxiccTclymphocytes
b. NaturalckillerccellscandccytoWtoWxW
ic.TTlBSM
ymph.oW
cyStes
c. MemorycTccellscandceffectorcTccells
d. Helperccellscandcantigen-presentingccells
e. CytotoxiccTclymphocytescandctargetccells
ANS:c c A
Tccellsccancbecclassifiedcintoceffectorcsubsetscthatcperformcdifferentceffectorcfunctions.cMostcef
fectorcTccellscareceitherchelpercTclymphocytes,cwhichcenhancecthecresponsescofcothercimmunec
cells,cincludingcphagocytescandcBccells,ctocinfections,corccytotoxiccTclymphocytes,cwhichcdire
ctlyckillcinfectedccells.cNaturalckillerccellscarecnotcTclymphocytes.
Antigen-presentingccellscusuallycarecnotcTccells.cMemorycTccellscarecnotceffectorcTccells.
6. Whichcofcthecfollowingccellctypesciscrequiredcforcallcadaptivechumoralcimmunecresponses?
a. Naturalckillerccells
b. Dendriticccells
c. CytolyticcTclymphocytes
d. Bclymphocytes
e. HelpercTclymphocytes
ANS:c c D
Humoralcimmunecresponsescarecantibody-
mediatedcimmunecresponses,candcallcantibodiescarecmadecbycBclymphocytescandcnocotherccellc
type.
PlusBay.Plus
Cellular and Molecular Immunology
c c c
Abul Abbas, Andrew Lichtman, and Shiv Pillai
c c c c c c
10th Edition
c
PlusBay.Plus
,Table of Contents
c c
Chapterc01cPropertiescandcOverviewcofcImmunecResponses 1
Chapterc02cCellscandcTissuescofcthecImmunecSystem 3
Chapterc03cLeukocytecCirculationcandcMigrationcIntocTissues 6
Chapterc04cInnatecImmunity 10
Chapterc05cAntibodiescandcAntigens 17
Chapterc06cAntigencPresentationctocTcLymphocytescandcthecFunctionscofcMajor
HistocompatibilitycComplexcMolecules 20
Chapterc07cImmunecReceptorscandcSignalcTransduction 27
Chapterc08cLymphocytecDevelopmentcandcAntigencReceptorcGenecRearrangement 30
Chapterc09cActivationcofcTcLymphocytes 34
Chapterc10cDifferentiationcandcFunctionscofcCD4+cEffectorcTcCells 38
Chapterc11cDifferentiationcandcFunctionscofcCD8+cEffectorcTcCells 42
Chapterc12cBcCellcActivationcandcAntibodycProduction 46
Chapterc13cEffectorcMechanismscofcHumoralcImmunity 52
Chapterc14cSpecializedcImmunitycatcEpithelialcBarrierscandcincImmunecPrivilegedcTissues 56
Chapterc15cImmunologiccTolerancecandcAutoimmunity 62
Chapterc16cImmunityctocMicrobes 67
Chapterc17cTransplantationcImmunology 72
Chapterc18cTumorcImmunology 77
Chapterc19cHypersensitivitycDisorders 81
Chapterc20cAllergy 86
Chapterc21cPrimarycandcAcquiredcImmunodeficiencies 89
PlusBay.Plus
,Chapter 01: Properties and Overview of Immune Responses
c c c c c c c
Abbas, Lichtman, and Pillai: Cellular and Molecular Immunology, 10th Edition
c c c c c c c c c
MULTIPLEcCHOICE
1. Thecprincipalcfunctioncofcthecimmunecsystemcis:
a. Defensecagainstccancer
b. Repaircofcinjuredctissues
c. Defensecagainstcmicrobialcinfections
d. Preventioncofcinflammatorycdiseases
e. Protectioncagainstcenvironmentalctoxins
ANS:c c C
Thecimmunecsystemchascevolvedcincthecsettingcofcselectivecpressurescimposedcbycmicrobialcinfec
tions.cAlthoughcimmunecresponsesctoccancercmaycoccur,cthecconceptcthatc“immunosurveillance”c
againstccancerciscacprincipalcfunctioncofcthecimmunecsystemcisccontroversial.cRepaircofcinjuredctis
suescmaycbecacsecondarycconsequencecofcthecimmunecresponsescandcinflammation.cAlthoughcthec
immunecsystemchascregulatorycfeaturescthatcarecneededctocpreventcexcessivecinflammation,cprev
entioncofcinflammatorycdiseasesciscnotcacprimarycfunction.cThecimmunecsystemccancprotectcagain
stcmicrobialctoxins,cbutcitcgenerallycdoescnotcoffercprotectioncagainstctoxinscofcnonbiologiccorigin
.
2. Whichcofcthecfollowingcinfectiouscdiseasescwascpreventedcbycthecfirstcsuccessfulcv
accination?
a. Polio
b. Tuberculosis
c. Smallpox
d. Tetanus
e. Rubella
ANS:c c C
Inc1798,cEdwardcJennercreportedcthecfirstcintentionalcsuccessfulcvaccination,cwhichcwascagain
stcsmallpoxcincacboy,cusingcmaterialcfromctheccowpoxcpustulescofcacmilkmaid.cInc1980,csmallpo
xcwascreportedctocbeceradicatedcworldwidecbycacvaccinationcprogram.cEffectivecvaccinescagai
nstctetanusctoxin,crubellacvirus,candcpolioviruscwerecdevelopedcincthec20thccenturycandcarecwid
elycused.cThereciscnoceffectivecvaccinecagainstcMycobacteriumctuberculosis.
3. Whichcofcthecfollowingciscacuniquecpropertycofcthecadaptivecimmunecsystem?
a. Highlycdiversecrepertoirecofcspecificitiescforcantigens
b. Self-nonselfc discrimination
c. Recognitioncofcmicrobialcstructurescbycbothccell-associatedcandcsolublecreceptors
d. Protectioncagainstcviralcinfections
e. Responsescthatchavecthecsameckineticscandcmagnitudeconcrepeatedcexposurectocthecs
amecmicrobe
ANS:c c A
PlusBay.Plus
, HighlycdiversecrepertoirescofcspecificitiescforcantigenscarecfoundconlycincTcandcBclymphocytes
,cwhichcarectheccentralccellularccomponentscofcthecadaptivecimmunecsystem.cBothcthecinnatecan
dcthecadaptivecimmunecsystemscuseccell-
associatedcandcsolublecreceptorsctocrecognizecmicrobes,cdisplaycsomecdegreecofcself-
nonselfcdiscrimination,candcprotectcagainstcviruses.cOncrepeatedcexposurectocthecsamecmicrob
e,cthecadaptivecimmunecresponsecbecomescmorecrapidcandcofcgreatercmagnitude;cthisciscthecma
nifestationcofcmemory.
4. AntibodiescandcTclymphocytescarecthecrespectivecmediatorscofcwhichctwoctypescofci
mmunity?
a. Innatecandcadaptive
b. Passivecandcactive
c. Specificcandcnonspecific
d. Humoralcandccell-mediated
e. Adultcandcneonatal
ANS:c c D
BothcBcandcTclymphocytescarecprincipalccomponentscofcadaptivecimmunity.cBclymphocytescpr
oducecantibodies,cwhichcarecthecrecognitioncandceffectorcmoleculescofchumoralcimmunecrespo
nsesctocextracellularcpathogens.cTccellscrecognizecandcpromoteceradicationcofcintracellularcpath
ogenscinccell-
mediatedcimmunity.cPassivecandcactivecimmunitycbothccancbecmediatedcbyceithercBcorcTclymph
ocytes.cSpecificcimmunityciscanotherctermcforcadaptivecimmunity.cBothcBcandcTclymphocytescp
articipatecincadultcadaptivecimmunitycbutcarecstillcdevelopingcincthecneonatalcperiod.
5. ThectwocmajorcfunctionalcclassescofceffectorcTclymphocytescare:
a. HelpercTclymphocytescandccytotoxiccTclymphocytes
b. NaturalckillerccellscandccytoWtoWxW
ic.TTlBSM
ymph.oW
cyStes
c. MemorycTccellscandceffectorcTccells
d. Helperccellscandcantigen-presentingccells
e. CytotoxiccTclymphocytescandctargetccells
ANS:c c A
Tccellsccancbecclassifiedcintoceffectorcsubsetscthatcperformcdifferentceffectorcfunctions.cMostcef
fectorcTccellscareceitherchelpercTclymphocytes,cwhichcenhancecthecresponsescofcothercimmunec
cells,cincludingcphagocytescandcBccells,ctocinfections,corccytotoxiccTclymphocytes,cwhichcdire
ctlyckillcinfectedccells.cNaturalckillerccellscarecnotcTclymphocytes.
Antigen-presentingccellscusuallycarecnotcTccells.cMemorycTccellscarecnotceffectorcTccells.
6. Whichcofcthecfollowingccellctypesciscrequiredcforcallcadaptivechumoralcimmunecresponses?
a. Naturalckillerccells
b. Dendriticccells
c. CytolyticcTclymphocytes
d. Bclymphocytes
e. HelpercTclymphocytes
ANS:c c D
Humoralcimmunecresponsescarecantibody-
mediatedcimmunecresponses,candcallcantibodiescarecmadecbycBclymphocytescandcnocotherccellc
type.
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