TESTBANK
CellularandMolecularImmunology
AbulAbbas,AndrewLichtman,andShivPillai
10thEdition
,TableofContents
Chapter01PropertiesandOverviewofImmuneResponses 1
Chapter02CellsandTissuesoftheImmuneSystem 3
Chapter03 LeukocyteCirculation andMigration IntoTissues 6
Chapter04Innate Immunity 10
Chapter05AntibodiesandAntigens 17
Chapter06AntigenPresentationtoTLymphocytesandtheFunctionsofMajor
HistocompatibilityComplex Molecules 20
Chapter07 ImmuneReceptors and Signal Transduction
b 27
Chapter08LymphocyteDevelopmentandAntigenReceptorGeneRearrangement
h h 30
Chapter09ActivationofT Lymphocytes 34
Chapter10DifferentiationandFunctionsofCD4+EffectorTCells 38
Chapter11DifferentiationandFunctionsofCD8+EffectorTCells 42
Chapter12 BCellActivation and AntibodyProduction
h 46
Chapter13EffectorMechanismsofHumoral Immunity 52
Chapter14Specialized Immunityat EpithelialBarriersandin ImmunePrivileged Tissues 56
Chapter15 ImmunologicToleranceand Autoimmunity 62
Chapter16 Immunityto Microbes 67
Chapter17TransplantationImmunology 72
Chapter18Tumor Immunology 77
Chapter19 HypersensitivityDisorders 81
Chapter20 Allergy 86
Chapter21Primaryand Acquired Immunodeficiencies 89
,Chapter01:PropertiesandOverviewofImmuneResponses
Abbas,Lichtman,andPillai:CellularandMolecularImmunology,10thEdition
b
MULTIPLECHOICE
1. Theprincipalfunctionoftheimmunesystemis:
a. Defenseagainstcancer
b. Repairofinjuredtissues
c. Defenseagainstmicrobialinfections
d. Preventionofinflammatorydiseases
e. Protectionagainstenvironmentaltoxins
ANS: C
Theimmunesystemhasevolvedinthesettingofselectivepressuresimposedbymicrobial
infections. Althoughimmuneresponses to cancer mayoccur, theconcept that
h h
“immunosurveillance” against cancer isa principalfunction oftheimmunesystem is
h
controversial. Repair ofinjured tissues maybea secondaryconsequence oftheimmune
h h h
responses and inflammation. Although theimmunesystem has regulatoryfeatures that are
needed to prevent excessive inflammation, prevention of inflammatory diseases is nota
primaryfunction.Theimmunesystemcanprotect againstmicrobialtoxins,butitgenerally does
b
not offer protection against toxinsof nonbiologic origin.
2. Whichofthefollowinginfectiousdiseaseswaspreventedbythefirstsuccessful
vaccination?
a. Polio
b. Tuberculosis
c. Smallpox
d. Tetanus
e. Rubella
ANS: C
In1798,EdwardJennerreportedthefirstintentionalsuccessfulvaccination,whichwasagainst
h h
smallpoxinaboy,usingmaterialfromthecowpoxpustulesofamilkmaid. In 1980, smallpox
wasreportedtobeeradicatedworldwidebyavaccinationprogram.Effectivevaccinesagainst
h
tetanus toxin, rubella virus, and poliovirusweredeveloped in the 20thcentury and
arewidely used. There is no effective vaccine against Mycobacteriumtuberculosis.
3. Whichofthefollowingis auniquepropertyoftheadaptiveimmunesystem?
b
a. Highlydiverserepertoireofspecificitiesforantigens
b. Self-nonselfdiscrimination
c. Recognitionofmicrobial structuresbybothcell-associatedand solublereceptors
b
d. Protectionagainstviralinfections
e. Responsesthathavethesamekineticsandmagnitudeonrepeatedexposuretothe
samemicrobe
ANS: A
, Highlydiverserepertoiresofspecificities forantigensarefoundonlyinTand Blymphocytes,
h h
whicharethecentralcellularcomponentsoftheadaptiveimmunesystem.Boththeinnateand
theadaptiveimmunesystemsusecell-associatedandsolublereceptors to recognize microbes,
display some degreeofself-nonself discrimination, and protect againstviruses.Onrepeated
exposuretothesamemicrobe, theadaptiveimmuneresponse becomes more rapid and of
greater magnitude; this isthe manifestation of memory.
4. Antibodiesand Tlymphocytesaretherespective mediatorsofwhichtwotypesof
b
immunity?
a. Innateandadaptive
b. Passiveandactive
c. Specificandnonspecific
d. Humoralandcell-mediated
e. Adultandneonatal
ANS: D
Both Band Tlymphocytes areprincipal components of adaptive immunity. Blymphocytes
produce antibodies, which arethe recognition and effector molecules of humoral immune
h h
responsestoextracellularpathogens.Tcellsrecognizeandpromoteeradicationofintracellular
h h
pathogensincell-mediatedimmunity. Passiveandactiveimmunitybothcanbe mediated by
eitherBorTlymphocytes.Specificimmunityisanothertermforadaptiveimmunity.BothBand T
lymphocytesparticipate in adult adaptive immunity but arestill developingin theneonatal
h h
period.
5. Thetwomajorfunctional classesofeffectorTlymphocytesare:
a. HelperTlymphocytesandcytotoxicTlymphocytes
b. NaturalkillercellsandcytoWtoWxW
ic.TTlByS
mMph.oW
cyStes
c. MemoryTcellsandeffectorTcells
d. Helpercellsandantigen-presentingcells
e. CytotoxicTlymphocytesandtarget cells
b b
ANS: A
Tcellscanbeclassifiedintoeffectorsubsetsthatperformdifferenteffectorfunctions.Most
h
effectorTcellsareeitherhelperTlymphocytes,whichenhancetheresponsesofotherimmune
h h h
cells, including phagocytes and Bcells, toinfections, or cytotoxic Tlymphocytes, which
directly kill infected cells. Natural killer cells arenot T lymphocytes.
h h
Antigen-presentingcellsusuallyarenotTcells.MemoryTcellsarenoteffectorTcells.
6. Whichofthefollowingcelltypesisrequiredforalladaptivehumoralimmuneresponses?
a. Naturalkillercells
b. Dendriticcells
c. CytolyticTlymphocytes
d. Blymphocytes
e. HelperTlymphocytes
ANS: D
Humoralimmuneresponsesareantibody-mediated immuneresponses,and allantibodiesare
b
madeby Blymphocytes and no other cell type.
CellularandMolecularImmunology
AbulAbbas,AndrewLichtman,andShivPillai
10thEdition
,TableofContents
Chapter01PropertiesandOverviewofImmuneResponses 1
Chapter02CellsandTissuesoftheImmuneSystem 3
Chapter03 LeukocyteCirculation andMigration IntoTissues 6
Chapter04Innate Immunity 10
Chapter05AntibodiesandAntigens 17
Chapter06AntigenPresentationtoTLymphocytesandtheFunctionsofMajor
HistocompatibilityComplex Molecules 20
Chapter07 ImmuneReceptors and Signal Transduction
b 27
Chapter08LymphocyteDevelopmentandAntigenReceptorGeneRearrangement
h h 30
Chapter09ActivationofT Lymphocytes 34
Chapter10DifferentiationandFunctionsofCD4+EffectorTCells 38
Chapter11DifferentiationandFunctionsofCD8+EffectorTCells 42
Chapter12 BCellActivation and AntibodyProduction
h 46
Chapter13EffectorMechanismsofHumoral Immunity 52
Chapter14Specialized Immunityat EpithelialBarriersandin ImmunePrivileged Tissues 56
Chapter15 ImmunologicToleranceand Autoimmunity 62
Chapter16 Immunityto Microbes 67
Chapter17TransplantationImmunology 72
Chapter18Tumor Immunology 77
Chapter19 HypersensitivityDisorders 81
Chapter20 Allergy 86
Chapter21Primaryand Acquired Immunodeficiencies 89
,Chapter01:PropertiesandOverviewofImmuneResponses
Abbas,Lichtman,andPillai:CellularandMolecularImmunology,10thEdition
b
MULTIPLECHOICE
1. Theprincipalfunctionoftheimmunesystemis:
a. Defenseagainstcancer
b. Repairofinjuredtissues
c. Defenseagainstmicrobialinfections
d. Preventionofinflammatorydiseases
e. Protectionagainstenvironmentaltoxins
ANS: C
Theimmunesystemhasevolvedinthesettingofselectivepressuresimposedbymicrobial
infections. Althoughimmuneresponses to cancer mayoccur, theconcept that
h h
“immunosurveillance” against cancer isa principalfunction oftheimmunesystem is
h
controversial. Repair ofinjured tissues maybea secondaryconsequence oftheimmune
h h h
responses and inflammation. Although theimmunesystem has regulatoryfeatures that are
needed to prevent excessive inflammation, prevention of inflammatory diseases is nota
primaryfunction.Theimmunesystemcanprotect againstmicrobialtoxins,butitgenerally does
b
not offer protection against toxinsof nonbiologic origin.
2. Whichofthefollowinginfectiousdiseaseswaspreventedbythefirstsuccessful
vaccination?
a. Polio
b. Tuberculosis
c. Smallpox
d. Tetanus
e. Rubella
ANS: C
In1798,EdwardJennerreportedthefirstintentionalsuccessfulvaccination,whichwasagainst
h h
smallpoxinaboy,usingmaterialfromthecowpoxpustulesofamilkmaid. In 1980, smallpox
wasreportedtobeeradicatedworldwidebyavaccinationprogram.Effectivevaccinesagainst
h
tetanus toxin, rubella virus, and poliovirusweredeveloped in the 20thcentury and
arewidely used. There is no effective vaccine against Mycobacteriumtuberculosis.
3. Whichofthefollowingis auniquepropertyoftheadaptiveimmunesystem?
b
a. Highlydiverserepertoireofspecificitiesforantigens
b. Self-nonselfdiscrimination
c. Recognitionofmicrobial structuresbybothcell-associatedand solublereceptors
b
d. Protectionagainstviralinfections
e. Responsesthathavethesamekineticsandmagnitudeonrepeatedexposuretothe
samemicrobe
ANS: A
, Highlydiverserepertoiresofspecificities forantigensarefoundonlyinTand Blymphocytes,
h h
whicharethecentralcellularcomponentsoftheadaptiveimmunesystem.Boththeinnateand
theadaptiveimmunesystemsusecell-associatedandsolublereceptors to recognize microbes,
display some degreeofself-nonself discrimination, and protect againstviruses.Onrepeated
exposuretothesamemicrobe, theadaptiveimmuneresponse becomes more rapid and of
greater magnitude; this isthe manifestation of memory.
4. Antibodiesand Tlymphocytesaretherespective mediatorsofwhichtwotypesof
b
immunity?
a. Innateandadaptive
b. Passiveandactive
c. Specificandnonspecific
d. Humoralandcell-mediated
e. Adultandneonatal
ANS: D
Both Band Tlymphocytes areprincipal components of adaptive immunity. Blymphocytes
produce antibodies, which arethe recognition and effector molecules of humoral immune
h h
responsestoextracellularpathogens.Tcellsrecognizeandpromoteeradicationofintracellular
h h
pathogensincell-mediatedimmunity. Passiveandactiveimmunitybothcanbe mediated by
eitherBorTlymphocytes.Specificimmunityisanothertermforadaptiveimmunity.BothBand T
lymphocytesparticipate in adult adaptive immunity but arestill developingin theneonatal
h h
period.
5. Thetwomajorfunctional classesofeffectorTlymphocytesare:
a. HelperTlymphocytesandcytotoxicTlymphocytes
b. NaturalkillercellsandcytoWtoWxW
ic.TTlByS
mMph.oW
cyStes
c. MemoryTcellsandeffectorTcells
d. Helpercellsandantigen-presentingcells
e. CytotoxicTlymphocytesandtarget cells
b b
ANS: A
Tcellscanbeclassifiedintoeffectorsubsetsthatperformdifferenteffectorfunctions.Most
h
effectorTcellsareeitherhelperTlymphocytes,whichenhancetheresponsesofotherimmune
h h h
cells, including phagocytes and Bcells, toinfections, or cytotoxic Tlymphocytes, which
directly kill infected cells. Natural killer cells arenot T lymphocytes.
h h
Antigen-presentingcellsusuallyarenotTcells.MemoryTcellsarenoteffectorTcells.
6. Whichofthefollowingcelltypesisrequiredforalladaptivehumoralimmuneresponses?
a. Naturalkillercells
b. Dendriticcells
c. CytolyticTlymphocytes
d. Blymphocytes
e. HelperTlymphocytes
ANS: D
Humoralimmuneresponsesareantibody-mediated immuneresponses,and allantibodiesare
b
madeby Blymphocytes and no other cell type.
