HMX Genetics Test Questions with Correct Answers

HMX Genetics Test Questions with Correct Answers SNV - ANSWER Any sequence change that affects one base of genome SNPs are common ones Promoter - ANSWER specific region of a gene where RNA polymerase can bind and begin transcription Nucleosome - ANSWER 150 bps of DNA around core proteins Stop Codons - ANSWER UAA, UAG, UGA Karyotype Analysis - ANSWER Usually done at metaphase Detects trisomy, deletions, duplications, translocations Confirming test FISH Analysis - ANSWER Fluorescent ss nucleic acid probe Done during metaphase or interphase Done fast but needs to be confirmed by karyotyping or microarray Microarray - ANSWER Fragment and label DNA Anneal DNA to microarray Used to detect CNVs Confirming test 5' UTR - ANSWER affects translation, RNA stability, and is transcribed Independent Assortment - ANSWER Recombination Random metaphase plate organization (2^23 combos) Haplotype - ANSWER A group of alleles of different genes on a single chromosome that are closely enough linked to be inherited usually as a unit=Haplotype Block (10-20kB segment with SNP) Gene inherited from single parent