Medical-Surgical Nursing MCQ Study Guide & Test Bank — Chapter-by-Chapter

Harrison's Principles of Internal Medicine
(Vol.1 & Vol.2)
22nd Edition
• Author(s)Joseph Loscalzo; Anthony S.
Fauci; Dennis L. Kasper; Stephen Hauser;
Dan Longo; J. Larry Jameson
Test Bank




Covered

PART 1: Foundations of Clinical Medicine

PART 2: Cardinal Symptoms & Clinical Presentations

PART 3: Clinical Pharmacology

PART 4: Oncology & Hematology

PART 5: Infectious Diseases

PART 6: Cardiovascular Disorders

PART 7: Respiratory Disorders

PART 8: Critical Care Medicine

PART 9: Kidney & Urinary Tract Disorders

PART 10: Gastrointestinal & Hepatobiliary Disorders

,PART 11: Immune-Mediated & Rheumatologic Disorders

PART 12: Endocrinology & Metabolism

PART 13: Neurologic & Psychiatric Disorders

PART 14: Toxicology & Environmental Injury

PART 15: Environmental & Occupational Medicine

PART 16: Genetics, Precision & Systems Medicine

PART 17–20: Special & Emerging Topics




1.
Question: A patient presents with non-specific fatigue and
weight loss. Which initial clinician behavior best reflects the
core principle of the modern “practice of medicine”?
A. Order a broad panel of screening tests immediately.
B. Elicit a focused history and perform an exam to guide
targeted testing.
C. Refer to multiple specialists before any primary evaluation.
D. Begin empiric therapy while awaiting a specialist opinion.
Answer: B
Rationale: The practice of medicine centers on problem-focused
history and physical exam to narrow the differential and guide
targeted diagnostics, avoiding unnecessary testing.
Citation: Harrison’s Principles of Internal Medicine, 22nd ed.,
Chapter: The Practice of Medicine
2.

,Question: For promoting good health in a clinic population,
which nursing intervention is highest-yield and population-
focused?
A. Providing disease-specific brochures at every visit.
B. Implementing brief behavioral counseling on tobacco
cessation for smokers.
C. Ordering annual full-body CT scans for patients over 40.
D. Referring all patients to specialty care regardless of risk.
Answer: B
Rationale: Brief behavioral counseling (e.g., for tobacco
cessation) is evidence-based, actionable, and scalable for
improving population health.
Citation: Harrison’s Principles of Internal Medicine, 22nd ed.,
Chapter: Promoting Good Health
3.
Question: A parent expresses strong vaccine hesitancy. Which
nursing approach is most likely to improve acceptance?
A. Insist vaccines are mandatory and refuse to discuss concerns.
B. Use a presumptive recommendation + address specific
concerns with empathy.
C. Defer all vaccines to a later date without discussion.
D. Offer long scientific monologues about vaccine
manufacturing.
Answer: B
Rationale: A presumptive recommendation combined with
empathetic, specific responses to concerns is more effective

, than confrontation or avoidance.
Citation: Harrison’s Principles of Internal Medicine, 22nd ed.,
Chapter: Vaccine Opposition and Hesitancy
4.
Question: When deciding whether to order a diagnostic test,
which principle from clinical decision-making should most
influence the nurse’s recommendation?
A. The test’s availability at the facility.
B. The test’s ability to meaningfully change post-test
management.
C. How commonly the test is ordered in other hospitals.
D. Patient preference only, regardless of pretest probability.
Answer: B
Rationale: Tests should be ordered when results will change
management; otherwise they add cost, delay, and potential
harm.
Citation: Harrison’s Principles of Internal Medicine, 22nd ed.,
Chapter: Decision-Making in Clinical Medicine
5.
Question: A patient with low pretest probability for pulmonary
embolism (PE) and a negative D-dimer — best next step?
A. Proceed to CT pulmonary angiography regardless.
B. No further imaging; PE is unlikely.
C. Start empiric anticoagulation immediately.
D. Repeat D-dimer in 24 hours.
Answer: B