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Biochemistry TCA - Summary Lippincott's Illustrated Reviews Biochemistry TCA cycle Krebs cycle Citric Acid cycle Metabolic pathway Coverts acetyl CoA—> CO2 Derives energy from reactions All reaction occur in mitochondria Produces NADH, FADH2—> electron transport chain (ATP) GTP, CO2 Oxaloacetate can be shunted to glucose by gluconeogenesis Step 1 Acetyl-CoA ———> Citrate Citrate: (also used in synthesis of fatty acid) 6 Carbon structure Oxaloacetate (4 carbo...

Glycolysis: Pathway objectives 1) Produce energy (ATP, NADH) 2) Produce precursors to biomass synthesis 3) Gets glucose carbons to a metabolic hub (Acetyl-CoA) • Why glucose? Why is it so abundant?  Glucose is stable and stays in closed-chain form, whereas other sugars prefer to be in the open-chain form, which reacts with –NH3 groups on amino acids, resulting in the glycosylation of proteins, which is bad because glycosylation is non-specific and inactivates proteins First 5 steps: ...

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