MMG 404 final questions with detailed
answers graded A+ 2025/2026 passed
globin’s have... - correct answer ✔✔8 alpha helices
globin’s bind to... - correct answer ✔✔heme cofactor which binds to oxygen
His92 - correct answer ✔✔critical for heme binding
Phe42 - correct answer ✔✔locks heme into specific pocket
hemoglobin structure - correct answer ✔✔heterotetramers containing 2 alpha globins and 2
beta globins
HbF - correct answer ✔✔fetal
2 alpha 2 gamma
HbA2 - correct answer ✔✔adult
2 alpha and ?
HbA - correct answer ✔✔adult
2 alpha 2 beta
beta globin genes - correct answer ✔✔HSA 11p
, alpha globin genes - correct answer ✔✔HSA 16p
which type of structure is strongest clue? - correct answer ✔✔primary
Hb (O2) - correct answer ✔✔transport
OI - correct answer ✔✔extracellular matrix
BRCA1/2 - correct answer ✔✔genome integrity
FHC - correct answer ✔✔metabolic receptors
CFTR - correct answer ✔✔ion transport
DMD - correct answer ✔✔cytoskeleton
retina - correct answer ✔✔extreme hyperoxia, limited cellular regeneration, metabolically
active (needs lots of oxygen)
heart muscle - correct answer ✔✔extreme energy requirement and burning, limited cellular
regeneration
neuron - correct answer ✔✔molecule trafficking, easy to "gum" up the machinery, limited
cellular regeneration
red blood cells - correct answer ✔✔carry O2, not clog veins, rapid turn over and renewal
answers graded A+ 2025/2026 passed
globin’s have... - correct answer ✔✔8 alpha helices
globin’s bind to... - correct answer ✔✔heme cofactor which binds to oxygen
His92 - correct answer ✔✔critical for heme binding
Phe42 - correct answer ✔✔locks heme into specific pocket
hemoglobin structure - correct answer ✔✔heterotetramers containing 2 alpha globins and 2
beta globins
HbF - correct answer ✔✔fetal
2 alpha 2 gamma
HbA2 - correct answer ✔✔adult
2 alpha and ?
HbA - correct answer ✔✔adult
2 alpha 2 beta
beta globin genes - correct answer ✔✔HSA 11p
, alpha globin genes - correct answer ✔✔HSA 16p
which type of structure is strongest clue? - correct answer ✔✔primary
Hb (O2) - correct answer ✔✔transport
OI - correct answer ✔✔extracellular matrix
BRCA1/2 - correct answer ✔✔genome integrity
FHC - correct answer ✔✔metabolic receptors
CFTR - correct answer ✔✔ion transport
DMD - correct answer ✔✔cytoskeleton
retina - correct answer ✔✔extreme hyperoxia, limited cellular regeneration, metabolically
active (needs lots of oxygen)
heart muscle - correct answer ✔✔extreme energy requirement and burning, limited cellular
regeneration
neuron - correct answer ✔✔molecule trafficking, easy to "gum" up the machinery, limited
cellular regeneration
red blood cells - correct answer ✔✔carry O2, not clog veins, rapid turn over and renewal
