SSRIs (Selective Serotonin Reuptake Inhibitor)
Mechanism of Action: SSRI drugs inhibits the reuptake of serotonin in the
brain.
Therapeutic Use: Major Depression, Bipolar, OCD, Bulimia Nervosa, Panic
Disorder.
Drug Names Adverse Reaction
1. Insomnia
1. Fluoxetine (Prozac)
2. GI Symptoms
2. Citalopram (Celexa)
3. Nervousness
3. Escitalopram (Lexapro)
4. Weight Gain
4. Sertraline (Zoloft)
5. Headache
5. Paroxetine (Paxil)
6. Sexual Dysfunction
Black Box Warning Administration
*Risk for Suicide* *Oral Use ONLY*
Serotonin Syndrome (*too much serotonin*)
Manifestations
Mental Confusion, Agitation, Difficulty concentrating, fever,
anxiety, hallucination, hypereflexia, diaphoresis, tremors.
Interactions/Patient Education
*Risk for serotonin syndrome when taken within 2 weeks of MAOIs or other SSRIs*
Takes 4-6 weeks to achieve clinical effectiveness
Take SSRIs in the in the morning to prevent insomia
Taking SSRIs with food can help with nausea and GI symptoms
Mechanism of Action: SSRI drugs inhibits the reuptake of serotonin in the
brain.
Therapeutic Use: Major Depression, Bipolar, OCD, Bulimia Nervosa, Panic
Disorder.
Drug Names Adverse Reaction
1. Insomnia
1. Fluoxetine (Prozac)
2. GI Symptoms
2. Citalopram (Celexa)
3. Nervousness
3. Escitalopram (Lexapro)
4. Weight Gain
4. Sertraline (Zoloft)
5. Headache
5. Paroxetine (Paxil)
6. Sexual Dysfunction
Black Box Warning Administration
*Risk for Suicide* *Oral Use ONLY*
Serotonin Syndrome (*too much serotonin*)
Manifestations
Mental Confusion, Agitation, Difficulty concentrating, fever,
anxiety, hallucination, hypereflexia, diaphoresis, tremors.
Interactions/Patient Education
*Risk for serotonin syndrome when taken within 2 weeks of MAOIs or other SSRIs*
Takes 4-6 weeks to achieve clinical effectiveness
Take SSRIs in the in the morning to prevent insomia
Taking SSRIs with food can help with nausea and GI symptoms
