PCOL 355 Lecture 10 Test Questions with Answers All Correct

PCOL 355 Lecture 10 Test Questions with Answers All Correct What is the market trend for therapeutic peptides? - Answer-Market nearly doubled in revenue from 2010 to 2018. What is the most common route of administration for peptides? - Answer-Parenteral (injectable) delivery. Why is parenteral delivery not ideal for peptides? - Answer-Poor compliance due to pain and discomfort. What can accelerate growth and decrease consumer cost for peptide delivery? - Answer-Technological advances to find non-conventional routes of administration. What are some challenges to peptide delivery? - Answer-GI tract degradation, short half-lives, conformational changes, stability issues, immunogenicity, and manufacturing complications. What are some physical changes that can limit therapeutic activity of proteins? - Answer-Denaturation, aggregation, and precipitation. What are some chemical processes that can limit therapeutic activity of proteins? - Answer-Hydrolysis, oxidation, deamidation, racemization, and isomerization. What are PEGylated biologics used for? - Answer-Used in viral DNA in vaccines or in large hormones for the treatment of diabetes, osteoporosis, and Alzheimer's. What are some characteristics of intranasal delivery? - Answer-Administered as a stable dry powder with rapid onset and good bioavailability.