Module 2 Exam

PORTAGE LEARNING NURS 231: Pathophysiology 2022 Module 2 Exam Question 1 3 / 3 pts True/False: Blood tests for tumor markers are the single best screening tool for cancer. Why or why not? Your Answer: False. Tumor markers, which can be used for establishig prognosis, monitoring treatment and detecting recurrent disease, have limitiations. Under benign situations, tumor markers can still be elevated. Whereas in early stages of malignancy, not elevated. They have a lack of specificity and are then limited in their ability to screen or diagnose accuratley. False, they are elevated in benign conditions, most are not elevated in the early stages of malignancy. Question 2 3 / 3 pts Tissue biopsy is of critical importance in what role? Your Answer: Play a critical role in histologic and cytologic studies for diagnosis of cancers. Diagnosing the correct cancer and histology. Question 3 4 / 4 pts 1. List two signs or symptoms a patient may present with that might indicate a cancer diagnosis: 2. What are two side effects commonly experienced by cancer patients? Your Answer: 1) Bleeding and/or weight loss 2) Anorexia, hair loss 1. Bleeding; sore that doesn’t heal; fluid in the pleural, pericardial, or peritoneal spaces; chest pain, shortness of breath, cough, abdominal discomfort or swelling. Other possible answers can include a mass or lump, pain (need to be specific), fatigue, fevers, weight loss 2. Weight loss, wasting of body fat and muscle tissue, weakness, anorexia, and anemia, fatigue, sleep disturbances Question 4 10 / 10 pts Explain the TNM system: Your Answer: TNM system is a detailed staging system, created by AJCC, is used by cancer facilites. It classifies cancers into stages using 3 tumor components; Tumor, Nodes, Metastasis. T is size and spread of the primary tumor. N is how involved the lymph nodes. M is the extent of metastatic involvement. Classification: Tx, T0, Tis, T1-4 Nx, N0, N1-3 Mx, M0, M1 T is the size and local spread of the primary tumor. N is the involvement of the regional lymph nodes. M is the extent of the metastatic involvement. Question 5 10 / 10 pts 1. When would surgery be appropriate in the treatment of cancer? 2. Most chemotherapeutic drugs cause pancytopenia due to bone marrow suppression. What are the 3 possible adverse outcomes of this? Your Answer: 1. Surgery can be used if the tumor is solid and small with well-defines margins. Also can be used to treat oncologic emergencies and be used as prophylactic measures. 2. 3 possible adverse outcomes are neutropenia, anemia, thrombocytopenia. 1. Surgery is often the first treatment for solid tumors. If the tumor is small with well-defined margins, it can be removed completely. It is also used for oncologic emergencies and prophylactic surgery in high risk patients. 2. Neutropenia- risk for infections Anemia- causing fatigue Thrombocytopenia- risk for bleeding Question 6 2.5 / 2.5 pts True/False: Cell proliferation is the process in which proliferating cells become more specialized cell types. True Correct! False False, cell differentiation Question 7 2.5 / 2.5 pts True/False: Cell differentiation is the process of increasing cell numbers by mitotic cell division. True Correct! False False, cell proliferation Question 8 2.5 / 2.5 pts What are two important properties that stem cells possess? Your Answer: Stem cells possess self-renewal and potency. Self renewal means that they can undergo mitotic divisions while maintaining undifferentiated state. Potency is the differentiation potential of stem cells. Potency and self-renewal Question 9 0 / 2.5 pts Which of the following are most likely to have arisen from an adult stem cell? You Answered Muscle Bone Correct Answer Epithelial Neural Question 10 4 / 4 pts What is angiogenesis? Why do tumors need it? Your Answer: Angiogenesis is the development of new blood vessels within the tumor. In order to continue growing, it must establish blood vessels and growth factors. development of new blood vessels within the tumor. They need it to continue to grow. Question 11 3 / 3 pts What are normal genes called that become cancer-causing if mutated? Your Answer: Proto-oncogenes and Tumor suppressor genes protooncogenes Question 12 1 / 3 pts What is a tumor suppressor gene? Give one example. Your Answer: It is a gene that codes for a protein that inhibits cell growth and signals apoptosis. An example is p53. Tumor suppressor genes are associated with gene underactivity. These genes slow down cell division, repair DNA mistakes, or tell cells when to die. BRCA1 or 2, TP53 Question 13 10 / 10 pts Determine if the tumor is benign or malignant based on the nomenclature: Papilloma Lipoma Leiomyosarcoma Hemangioma Adenocarcinoma Neuroblastoma Adenoma Melanoma Lymphoma Glioma Question 14 10 / 10 pts A 62-year-old man with a 30-pack year smoking history is diagnosed with small cell lung cancer with metastasis to the bone. (1) Explain the process of how cancer spreads metastatically. (2) What symptoms might he have presented with? (3) Which screening test would he have benefited from? Your Answer: 1. Metastasis is a multi-step process. Cancer cells breaks loose from the primary tumor and enters circulation via a blood vessel or lymp system. It finds a new favorable location to invade, grow, and establish blood supply. 2. Patient might have presented with shortness of breath, chest pain, and cough. 3. Patient would have benefited from a chest CT scan. (1) Metastasis- a cancer cell must break loose from the primary tumor, invade the surrounding extracellular matrix, gain access to a blood vessel, survive its passage in the bloodstream, emerge at a favorable location, invade the surrounding tissue, begin to grow, and establish a blood supply. (2) Chest pain, shortness of breath, cough, bone pain. (3) Yearly low-dose chest CT. Question 15 3 / 3 pts Benign tumors have which of the following characteristics? Select all that apply. Undifferentiated cells Correct!