NR 547 Psychosis - Week 3 Questions with Verified Answers
(Correct Update)
Question 1: Environmental triggers for the onset of schizophrenia
Answer: Regular cannabis use Exposure to early life trauma (sexual abuse, emotional abuse, emotional
neglect, bullying)
Question 2: Heritability for schizophrenia
Answer: 79%
Question 3: Malfunctioning circuitry for negative and affective symptoms of schizophrenia
Answer: mesocortical and ventromedial prefrontal cortex
Question 4: Malfunctioning circuitry for cognitive symptoms of schizophrenia
Answer: dorsolateral prefrontal cortex
Question 5: Malfunctioning circuitry for aggressive, and impulsive symptoms of schizophrenia
Answer: orbitofrontal and connections to the amygdala
Question 6: Does overactivation or underactivation of dopamine lead to positive symptoms of
schizophrenia in the mesolimbic pathway
Answer: overactivation
Question 7: Hyperactivation or hypoactivation of the mesocortical pathway lead to negative,
cognitive and affective symptoms of schizophrenia
Answer: hypoactivation
Question 8: Result of low dopamine in the basal ganglia
Answer: akathesia and dystonia
Question 9: Pathway responsible for extrapyramidal nervous system which controls posture and
vountary motor movements
Answer: nigrostriatal pathway
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, Question 10: disruption of this pathway can cause prolactin tuberoinfundibular levels to rise,
resulting in gynecomastia and galactorrhea in males and females. Females can also experience
amenorrhea. Males and females can experience sexual dysfunction.
Answer: pathway
Question 11: What role does glutamate play in schizophrenia
Answer: Normally the glutamate pathway inhibits the mesolimbic pathway, however in schizophrenia,
the glutamate pathway becomes hypoactive which may lead to the hyperactivity of the mesolimbic DA
pathway, causing the positive symptoms of schizophrenia
Question 12: Underlying medical condition that can cause psychosis
Answer: endocrine, vascular, immunologic or metabolic problems
Question 13: Cognitive symptoms psychosis
Answer: disorganization in thoughts, memories, focus or attention
Question 14: delusions related to being threatened, victimized, or spied on
Answer: Persecution
Question 15: delusions related to receiving personal messages from tv, radio, or actions of others
Answer: reference
Question 16: delusions related to the body, including illness somatic
Answer: or the presence of foreign objects (e.g. Sometimes people believe there are objects in their
bodies; for example they might think they are infested with insects.)
Question 17: delusions related to beliefs of special abilities or powers
Answer: grandeur
Question 18: delusions that actions and thoughts are controlled by others
Answer: control
Question 19: Common comorbidities with schizophrenia
Answer: heart and liver disease and diabetes.
Page 2
(Correct Update)
Question 1: Environmental triggers for the onset of schizophrenia
Answer: Regular cannabis use Exposure to early life trauma (sexual abuse, emotional abuse, emotional
neglect, bullying)
Question 2: Heritability for schizophrenia
Answer: 79%
Question 3: Malfunctioning circuitry for negative and affective symptoms of schizophrenia
Answer: mesocortical and ventromedial prefrontal cortex
Question 4: Malfunctioning circuitry for cognitive symptoms of schizophrenia
Answer: dorsolateral prefrontal cortex
Question 5: Malfunctioning circuitry for aggressive, and impulsive symptoms of schizophrenia
Answer: orbitofrontal and connections to the amygdala
Question 6: Does overactivation or underactivation of dopamine lead to positive symptoms of
schizophrenia in the mesolimbic pathway
Answer: overactivation
Question 7: Hyperactivation or hypoactivation of the mesocortical pathway lead to negative,
cognitive and affective symptoms of schizophrenia
Answer: hypoactivation
Question 8: Result of low dopamine in the basal ganglia
Answer: akathesia and dystonia
Question 9: Pathway responsible for extrapyramidal nervous system which controls posture and
vountary motor movements
Answer: nigrostriatal pathway
Page 1
, Question 10: disruption of this pathway can cause prolactin tuberoinfundibular levels to rise,
resulting in gynecomastia and galactorrhea in males and females. Females can also experience
amenorrhea. Males and females can experience sexual dysfunction.
Answer: pathway
Question 11: What role does glutamate play in schizophrenia
Answer: Normally the glutamate pathway inhibits the mesolimbic pathway, however in schizophrenia,
the glutamate pathway becomes hypoactive which may lead to the hyperactivity of the mesolimbic DA
pathway, causing the positive symptoms of schizophrenia
Question 12: Underlying medical condition that can cause psychosis
Answer: endocrine, vascular, immunologic or metabolic problems
Question 13: Cognitive symptoms psychosis
Answer: disorganization in thoughts, memories, focus or attention
Question 14: delusions related to being threatened, victimized, or spied on
Answer: Persecution
Question 15: delusions related to receiving personal messages from tv, radio, or actions of others
Answer: reference
Question 16: delusions related to the body, including illness somatic
Answer: or the presence of foreign objects (e.g. Sometimes people believe there are objects in their
bodies; for example they might think they are infested with insects.)
Question 17: delusions related to beliefs of special abilities or powers
Answer: grandeur
Question 18: delusions that actions and thoughts are controlled by others
Answer: control
Question 19: Common comorbidities with schizophrenia
Answer: heart and liver disease and diabetes.
Page 2
