URI NUR 243 Exam #1 Question with verified answers
older adult drug absorption changes - √√rate slowed
% absorbed stays the same
older adult drug distribution change - √√decreased albumin and binding = more free drugs = high chance
toxicity
older adult drug metabolism changes - √√rate slowed
decreased hepatic BF / liver mass = higher response to oral drugs
older adult drug excretion changes - √√decreased renal BF = high drug accumulation, high adverse effects
older adult pharmacodynamic changes - √√receptor alteration = more intense effects
beta blockers less effective
Beers List - √√potentially inappropriate medications in the elderly
end of life care - √√disease prevention becomes comfort
inappropriate drugs may become appropriate and vice versa
pharmacokinetics - √√the study of drug movement throughout the body
absorption - √√drug movement from the site of injection into the blood
increased lipid solubility leads to ____ absorption - √√increased
IV absorption - √√immediate
IM / subcutaneous absorption - √√rapid if H2O soluble
poor if not
oral absorption - √√slow, variable
enteral - √√within GI tract - oral
parenteral - √√outside GI tract - IV, IM, subcutaneous
distribution - √√drug travels from blood into tissue and cells
increased tissue blood flow leads to ___ distribution - √√increased
protein bound drugs - √√can't cross capillary walls
older adult drug absorption changes - √√rate slowed
% absorbed stays the same
older adult drug distribution change - √√decreased albumin and binding = more free drugs = high chance
toxicity
older adult drug metabolism changes - √√rate slowed
decreased hepatic BF / liver mass = higher response to oral drugs
older adult drug excretion changes - √√decreased renal BF = high drug accumulation, high adverse effects
older adult pharmacodynamic changes - √√receptor alteration = more intense effects
beta blockers less effective
Beers List - √√potentially inappropriate medications in the elderly
end of life care - √√disease prevention becomes comfort
inappropriate drugs may become appropriate and vice versa
pharmacokinetics - √√the study of drug movement throughout the body
absorption - √√drug movement from the site of injection into the blood
increased lipid solubility leads to ____ absorption - √√increased
IV absorption - √√immediate
IM / subcutaneous absorption - √√rapid if H2O soluble
poor if not
oral absorption - √√slow, variable
enteral - √√within GI tract - oral
parenteral - √√outside GI tract - IV, IM, subcutaneous
distribution - √√drug travels from blood into tissue and cells
increased tissue blood flow leads to ___ distribution - √√increased
protein bound drugs - √√can't cross capillary walls
