9/9/26, 9:20 AM NR507 Advanced Pathophysiology MidTerm EXAM Questions & Answers | With 100% Correct Answers graded A+ (updated 2027) G…
NR507 Advanced Pathophysiology MidTerm EXAM
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Terms in this set (55)
Hypersensitivity: Type 1 Type 1: Allergic reaction, Mediated by IgE,
Inflammation due to mast cell degranulation
Local symptoms:
-itching
-rash
Systemic symptoms:
-wheezing
Most dangerous = anaphylactic reaction
systemic response of hypotension, severe
bronchoconstriction
Main treatment: epinephrine reverses the effects
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Hypersensitivity: Type 2 Type 2: Cytotoxic reaction; tissue specific (ex: thyroid
tissue)
Macrophages are the primary effectors cells involved
Can cause tissue damage or alter function
Grave's disease (hyperthyroidism) - example of
altering thyroid function, but does not destroy thyroid
tissue
Incompatible blood type- example of cell/tissue
damage that occurs; severe transfusion reaction
occurs and the transfused erythrocytes are destroyed
by agglutination or complement-mediated lysis.
Type 1 Hypersensitivity VS. Type 2 Type 1 Hypersensitivity
Hypersensitivity Organ Specific
Antibody binds to the antigen on the cell surface
Type 2 Hypersensitivity
Not Organ Specific
Antibody binds to the soluble antigen outside the cell
surface that was released into the blood or body
fluids, and the complex is then deposited in the tissues
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Hypersensitivity: Type 3 - Examples Rheumatoid arthritis: Antigen/antibodies are
deposited in the joints
Systemic Lupus Erythematosus (SLE)- very closely
related to autoimmunity- antigen/antibodies deposit in
organs that cause tissue damage
Hypersensitivity: Type 4 Delayed response
Does not involve antigen/antibody complexes like
Types 1, 2 and 3
Is T-cell mediated
Differentiating Between the Rash of a Type 1: Immediate hypersensitivity reactions, termed
Type 1 vs. Type 4 Reaction: atopic dermatitis, are usually characterized by widely
distributed lesions
Type 4: Contact dermatitis (delayed hypersensitivity)
consists of lesions only at the site of contact with the
allergen
The key determinant is the timing of the rash:
-Type 1 = Immediate
-Type 4 = Delayed: Several days following contact, ex
would be poison ivy
Treatment of Type 4 Rash A non-severe case of contact dermatitis would be
treated with topical corticosteroid.
Why not epinephrine or antihistamines?
-Epinephrine is for emergent Type 1 anaphylactic
reactions. Antihistamines act on the H1 receptors. Type
4 does not involve mast cells and H1 receptors.
Antibiotics not appropriate since not an infection
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NR507 Advanced Pathophysiology MidTerm EXAM
Questions & Answers | With 100% Correct Answers
graded A+ (updated 2027) Guaranteed Success!!
Add to calendar
Play your way to mastery with fun games
Match Blocks Charms NEW
Terms in this set (55)
Hypersensitivity: Type 1 Type 1: Allergic reaction, Mediated by IgE,
Inflammation due to mast cell degranulation
Local symptoms:
-itching
-rash
Systemic symptoms:
-wheezing
Most dangerous = anaphylactic reaction
systemic response of hypotension, severe
bronchoconstriction
Main treatment: epinephrine reverses the effects
https://quizlet.com/1206275659/nr507-advanced-pathophysiology-midterm-exam-questions-answers-with-100-correct-answers-graded-a-updated-20… 1/18
,9/9/26, 9:20 AM NR507 Advanced Pathophysiology MidTerm EXAM Questions & Answers | With 100% Correct Answers graded A+ (updated 2027) G…
Hypersensitivity: Type 2 Type 2: Cytotoxic reaction; tissue specific (ex: thyroid
tissue)
Macrophages are the primary effectors cells involved
Can cause tissue damage or alter function
Grave's disease (hyperthyroidism) - example of
altering thyroid function, but does not destroy thyroid
tissue
Incompatible blood type- example of cell/tissue
damage that occurs; severe transfusion reaction
occurs and the transfused erythrocytes are destroyed
by agglutination or complement-mediated lysis.
Type 1 Hypersensitivity VS. Type 2 Type 1 Hypersensitivity
Hypersensitivity Organ Specific
Antibody binds to the antigen on the cell surface
Type 2 Hypersensitivity
Not Organ Specific
Antibody binds to the soluble antigen outside the cell
surface that was released into the blood or body
fluids, and the complex is then deposited in the tissues
https://quizlet.com/1206275659/nr507-advanced-pathophysiology-midterm-exam-questions-answers-with-100-correct-answers-graded-a-updated-20… 2/18
, 9/9/26, 9:20 AM NR507 Advanced Pathophysiology MidTerm EXAM Questions & Answers | With 100% Correct Answers graded A+ (updated 2027) G…
Hypersensitivity: Type 3 - Examples Rheumatoid arthritis: Antigen/antibodies are
deposited in the joints
Systemic Lupus Erythematosus (SLE)- very closely
related to autoimmunity- antigen/antibodies deposit in
organs that cause tissue damage
Hypersensitivity: Type 4 Delayed response
Does not involve antigen/antibody complexes like
Types 1, 2 and 3
Is T-cell mediated
Differentiating Between the Rash of a Type 1: Immediate hypersensitivity reactions, termed
Type 1 vs. Type 4 Reaction: atopic dermatitis, are usually characterized by widely
distributed lesions
Type 4: Contact dermatitis (delayed hypersensitivity)
consists of lesions only at the site of contact with the
allergen
The key determinant is the timing of the rash:
-Type 1 = Immediate
-Type 4 = Delayed: Several days following contact, ex
would be poison ivy
Treatment of Type 4 Rash A non-severe case of contact dermatitis would be
treated with topical corticosteroid.
Why not epinephrine or antihistamines?
-Epinephrine is for emergent Type 1 anaphylactic
reactions. Antihistamines act on the H1 receptors. Type
4 does not involve mast cells and H1 receptors.
Antibiotics not appropriate since not an infection
https://quizlet.com/1206275659/nr507-advanced-pathophysiology-midterm-exam-questions-answers-with-100-correct-answers-graded-a-updated-20… 3/18
