BCPS TEST EVALS ANSWERS AND QUESTIONS SET
A+
✔✔FD&C Act of 1938 - required proof of ? - ✔✔safety (thalimide)
✔✔Defauver-harris amendment of 1962 required proof of? - ✔✔efficacy
✔✔Generic drug pathway act was? - ✔✔Hatch-Waxman Act - Drug price competition
and patent term restoration acto f 1984
✔✔Durham-humphrey amendment of 1951 did what - ✔✔established difference
between Rx and non-rx
✔✔SSRIs with greatest 2D6 inhibition - ✔✔bupropion, fluoxetine, paroxetine (very high)
✔✔SSRIs with greatest 1A2 inhibition - ✔✔fluvoxamine (high)
✔✔first line antidepressants - ✔✔SSRI, SNRI, mirtaz, bupro - NOT TCA bc of suicide
potential (success)
✔✔SSRI with longest half life - ✔✔fluoxetine
✔✔activating SSRIs - ✔✔sertraline, fluoxetine
✔✔sedating SSRIs - ✔✔paroxetine, fluvoxamine
✔✔SNRIs (names) - ✔✔venlafaxine, desvenlax, duloxetine, levomilnacipran
✔✔most common side effects of SSRI, SNRIs - ✔✔headache, GI complaints, sexual
dysfunction
,✔✔SNRI with other indications - ✔✔duloxetine - periph neuropathy, fibromyalgia,
muscloskeletal pain; DDI with 2D6 mes
✔✔side effects of mirtazapine - ✔✔sedation (at low doses), weight gain, increased
appetite, constipation, asthenia
✔✔best SSRI for pregnancy - ✔✔fluoxetine, sertraline, maybe bupropion
✔✔main treatments for bipolar - ✔✔mood stabelizers: lithium, anticonvulsants (VPA,
carbamaz - not first line); 2nd gen atypicals
✔✔lithium serum concentration goal - ✔✔0.8-1, acute or 0.6-1 for maintenance - highly
renally eliminated/depend on Na concentrations
✔✔med choices for IM acute symptom managemnet of biopolar - ✔✔IM aripiprazole,
olanzapine, haldol/benztropine
✔✔agent indicated for depression part of bipolar - ✔✔lurasidone, mood stabilizers, not
antidepressants, quetiapine
✔✔schizo diagnosis - pt must exhibit one of what three symptoms - ✔✔hallucinations,
delusions, disorganized speech
✔✔agent of choice for treatment resistant schizo? - ✔✔clozapine; CI for WBC <3500
✔✔agents to treat pseudo-parkinson from antipsychotics? - ✔✔benztropine,
diphenydramine, , trihexyphenidyl
✔✔agents to treat akathisia from antipsychotics - ✔✔propanolol (lipophilic beta
blockers)
✔✔antipsycho that does NOT develop tardive dyskinesia - ✔✔clozapine (intervention of
choice)
✔✔biggest benefit and ade with second generation antipsychotics - ✔✔lower EPS,
higher metabolic syndromes
✔✔SGAs with highest weight gain - ✔✔clozapine, olanzapine (sedation too, and
quetiapine)
✔✔SGA with greatest effect on QTc - ✔✔ziprasadone, less weight gain
✔✔SGA with greatest risk of
hyperprolactemia - ✔✔risperidone. EPS high too
, ✔✔SGA with high incidence of akathesia - ✔✔aripiprazole
✔✔benzo with long half life - ✔✔diazepam; has active metabolites - relies on liver
function for elimination/metabolism
✔✔benzo of choice in pts iwth liver or renal dysfunction - ✔✔lorazepam
✔✔onset for buspirone in anxiety disorders - ✔✔2-4 weeks (only used to treat GAD)
✔✔antidepressant with antianxiety and antipanic effects - ✔✔venlafaxine
✔✔PTSD treatment of choice if nightmares, insomnia - ✔✔prazosin
✔✔PTSD treatment of choice for impulsive anger - ✔✔lamotrigine, anticonvulsants
(appears to be MOA GABA modulated/fix)
✔✔general treatment of choice for PTSD - ✔✔SSRIs, venlafaxine, mirtazapine (not first
line)
✔✔treatment of choice for OCD - ✔✔SSRIs: fluoxetine, fluvoxamine, paroxetine,
sertraline
✔✔Z drug for sleep maintence - ✔✔eszolpiclone (surovexant too)
✔✔categories of albuminuria/proteinuria - ✔✔A1 < 30, A2 30-300, A3 >300, nephrontic
> 3000
✔✔GFR categories per KDIGO in CKD - ✔✔G1 >90, G2 60-89, G3a 45-59, G3b 30-44,
G4 15-29, G5 < 15
✔✔indications for RRT - ✔✔AEIOU
A - acidosis
E - electrolyte abnorm
I - intoxication
O - overload, fluid
U - uremia
✔✔perferred ABX treatment of perioto3nitis - ✔✔gram pos, gram neg - empirically cover
both
vanco or first gen cephalosporin (intraperiotoneal)
ANd
IP 3rd gen ceph or aminoglycoside
A+
✔✔FD&C Act of 1938 - required proof of ? - ✔✔safety (thalimide)
✔✔Defauver-harris amendment of 1962 required proof of? - ✔✔efficacy
✔✔Generic drug pathway act was? - ✔✔Hatch-Waxman Act - Drug price competition
and patent term restoration acto f 1984
✔✔Durham-humphrey amendment of 1951 did what - ✔✔established difference
between Rx and non-rx
✔✔SSRIs with greatest 2D6 inhibition - ✔✔bupropion, fluoxetine, paroxetine (very high)
✔✔SSRIs with greatest 1A2 inhibition - ✔✔fluvoxamine (high)
✔✔first line antidepressants - ✔✔SSRI, SNRI, mirtaz, bupro - NOT TCA bc of suicide
potential (success)
✔✔SSRI with longest half life - ✔✔fluoxetine
✔✔activating SSRIs - ✔✔sertraline, fluoxetine
✔✔sedating SSRIs - ✔✔paroxetine, fluvoxamine
✔✔SNRIs (names) - ✔✔venlafaxine, desvenlax, duloxetine, levomilnacipran
✔✔most common side effects of SSRI, SNRIs - ✔✔headache, GI complaints, sexual
dysfunction
,✔✔SNRI with other indications - ✔✔duloxetine - periph neuropathy, fibromyalgia,
muscloskeletal pain; DDI with 2D6 mes
✔✔side effects of mirtazapine - ✔✔sedation (at low doses), weight gain, increased
appetite, constipation, asthenia
✔✔best SSRI for pregnancy - ✔✔fluoxetine, sertraline, maybe bupropion
✔✔main treatments for bipolar - ✔✔mood stabelizers: lithium, anticonvulsants (VPA,
carbamaz - not first line); 2nd gen atypicals
✔✔lithium serum concentration goal - ✔✔0.8-1, acute or 0.6-1 for maintenance - highly
renally eliminated/depend on Na concentrations
✔✔med choices for IM acute symptom managemnet of biopolar - ✔✔IM aripiprazole,
olanzapine, haldol/benztropine
✔✔agent indicated for depression part of bipolar - ✔✔lurasidone, mood stabilizers, not
antidepressants, quetiapine
✔✔schizo diagnosis - pt must exhibit one of what three symptoms - ✔✔hallucinations,
delusions, disorganized speech
✔✔agent of choice for treatment resistant schizo? - ✔✔clozapine; CI for WBC <3500
✔✔agents to treat pseudo-parkinson from antipsychotics? - ✔✔benztropine,
diphenydramine, , trihexyphenidyl
✔✔agents to treat akathisia from antipsychotics - ✔✔propanolol (lipophilic beta
blockers)
✔✔antipsycho that does NOT develop tardive dyskinesia - ✔✔clozapine (intervention of
choice)
✔✔biggest benefit and ade with second generation antipsychotics - ✔✔lower EPS,
higher metabolic syndromes
✔✔SGAs with highest weight gain - ✔✔clozapine, olanzapine (sedation too, and
quetiapine)
✔✔SGA with greatest effect on QTc - ✔✔ziprasadone, less weight gain
✔✔SGA with greatest risk of
hyperprolactemia - ✔✔risperidone. EPS high too
, ✔✔SGA with high incidence of akathesia - ✔✔aripiprazole
✔✔benzo with long half life - ✔✔diazepam; has active metabolites - relies on liver
function for elimination/metabolism
✔✔benzo of choice in pts iwth liver or renal dysfunction - ✔✔lorazepam
✔✔onset for buspirone in anxiety disorders - ✔✔2-4 weeks (only used to treat GAD)
✔✔antidepressant with antianxiety and antipanic effects - ✔✔venlafaxine
✔✔PTSD treatment of choice if nightmares, insomnia - ✔✔prazosin
✔✔PTSD treatment of choice for impulsive anger - ✔✔lamotrigine, anticonvulsants
(appears to be MOA GABA modulated/fix)
✔✔general treatment of choice for PTSD - ✔✔SSRIs, venlafaxine, mirtazapine (not first
line)
✔✔treatment of choice for OCD - ✔✔SSRIs: fluoxetine, fluvoxamine, paroxetine,
sertraline
✔✔Z drug for sleep maintence - ✔✔eszolpiclone (surovexant too)
✔✔categories of albuminuria/proteinuria - ✔✔A1 < 30, A2 30-300, A3 >300, nephrontic
> 3000
✔✔GFR categories per KDIGO in CKD - ✔✔G1 >90, G2 60-89, G3a 45-59, G3b 30-44,
G4 15-29, G5 < 15
✔✔indications for RRT - ✔✔AEIOU
A - acidosis
E - electrolyte abnorm
I - intoxication
O - overload, fluid
U - uremia
✔✔perferred ABX treatment of perioto3nitis - ✔✔gram pos, gram neg - empirically cover
both
vanco or first gen cephalosporin (intraperiotoneal)
ANd
IP 3rd gen ceph or aminoglycoside
