Path quiz 1
Path quiz 1
Study online at https://quizlet.com/_ihtfxd
1. Mx:
Intervertebral disc degeneration with mineralization
of nucleus pulposus
Underlying genetic condition: Chondrodysplasia
(Hansen type I disease)
Sequela:
Herniation of degenerate disc material —> paralysis
2. Most likely neoplastic diagnosis if aggressive:
Periarticular histiocytic sarcoma
6 predisposed dog breeds:
1. Bernese mountain dogs
2. Rottweilers
3. Bullmastiffs
4. Golden retrievers
5. Labrador retrievers
6. Flat-coated retrievers
Primary differential:
Synovial cell sarcoma
These are the differentials here, because the disease is
not confined to one bone - it "crosses the joint"
Immunohistochemical markers for macrophages (the
cell of histiocytic sarcoma): CD18, CD204, Iba1
3. Mx:
Osteosarcoma
1
, Path quiz 1
Path quiz 1
Study online at https://quizlet.com/_ihtfxd
Unlike periarticular histiocytic sarcoma, the tumor
should not cross the joint!
5 most common appendicular locations in dogs:
1. Proximal humerus
2. Distal radius/ulna
3. Distal femur
4. Proximal tibia
5. Distal tibia
"Away from the elbow, towards the knee + distal tibia"
Prognosis in dogs vs cats:
> 2 years average in cats (substantially longer than in
dogs)
4. Mx:
Necrohemorrhagic myositis
Name the disease:
Blackleg
Cause:
Clostridium chauvoei
Pathogenesis:
Ingestion of clostridium —> travels to muscle & spores
lay dormant —> trauma —> creation of anaerobic envi-
ronment —> spores activate and bacteria reproduces
—> release of alpha, beta, gamma, and delta toxins —>
necrosis
5.
2
Path quiz 1
Study online at https://quizlet.com/_ihtfxd
1. Mx:
Intervertebral disc degeneration with mineralization
of nucleus pulposus
Underlying genetic condition: Chondrodysplasia
(Hansen type I disease)
Sequela:
Herniation of degenerate disc material —> paralysis
2. Most likely neoplastic diagnosis if aggressive:
Periarticular histiocytic sarcoma
6 predisposed dog breeds:
1. Bernese mountain dogs
2. Rottweilers
3. Bullmastiffs
4. Golden retrievers
5. Labrador retrievers
6. Flat-coated retrievers
Primary differential:
Synovial cell sarcoma
These are the differentials here, because the disease is
not confined to one bone - it "crosses the joint"
Immunohistochemical markers for macrophages (the
cell of histiocytic sarcoma): CD18, CD204, Iba1
3. Mx:
Osteosarcoma
1
, Path quiz 1
Path quiz 1
Study online at https://quizlet.com/_ihtfxd
Unlike periarticular histiocytic sarcoma, the tumor
should not cross the joint!
5 most common appendicular locations in dogs:
1. Proximal humerus
2. Distal radius/ulna
3. Distal femur
4. Proximal tibia
5. Distal tibia
"Away from the elbow, towards the knee + distal tibia"
Prognosis in dogs vs cats:
> 2 years average in cats (substantially longer than in
dogs)
4. Mx:
Necrohemorrhagic myositis
Name the disease:
Blackleg
Cause:
Clostridium chauvoei
Pathogenesis:
Ingestion of clostridium —> travels to muscle & spores
lay dormant —> trauma —> creation of anaerobic envi-
ronment —> spores activate and bacteria reproduces
—> release of alpha, beta, gamma, and delta toxins —>
necrosis
5.
2
