Page 1 of 190
LEIK FNP Practice Questions and Answers.
1. A 55-year-old obese male with hypertension asks about
colorectal cancer screening. He has no family history. What
is the most appropriate initial test?
A. Colonoscopy every 10 years
B. Annual fecal immunochemical test (FIT)
C. CT colonography every 5 years
D. Flexible sigmoidoscopy every 5 years
Answer: B
Rationale: USPSTF recommends annual FIT, colonoscopy q10y,
or CT colonography q5y for average-risk adults 45–75. FIT is
noninvasive, easy, and a reasonable initial test. Shared
decision-making is key.
,Page 2 of 190
2. A 32-year-old G2P1 woman at 10 weeks gestation asks
about exercise. She ran marathons before pregnancy. What
is best advice?
A. Stop running to prevent preterm labor
B. Continue running but avoid overheating and dehydration
C. Switch to only walking after first trimester
D. Limit heart rate to <120 bpm
Answer: B
Rationale: ACOG encourages continuation of prepregnancy
exercise with precautions (hydration, avoid supine after 16
weeks, avoid trauma risk). No evidence that running causes
preterm labor.
3. Which vaccine is contraindicated in pregnancy?
A. Tdap
B. Influenza (inactivated)
C. MMR
D. Hepatitis B
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Answer: C
Rationale: MMR is a live attenuated vaccine and is
contraindicated in pregnancy due to theoretical risk to the
fetus. Tdap (27–36 weeks), inactivated flu, and Hep B are
safe.
4. A 68-year-old woman with osteoporosis takes
alendronate. What counseling is most important?
A. Take with orange juice to enhance absorption
B. Remain upright for 30–60 minutes after dosing
C. Take at bedtime with food
D. Chew tablet for faster effect
Answer: B
Rationale: Alendronate can cause esophageal irritation and
ulceration. Patients must take it with a full glass of water on an
empty stomach and remain upright for 30–60 minutes.
5. A healthy 24-year-old male asks about testicular self-
exam. USPSTF recommendation?
, Page 4 of 190
A. Annual exam by provider only
B. Monthly self-exam for all males 15–35
C. Insufficient evidence to recommend routine self-exam
D. Self-exam only if family history of testicular cancer
Answer: C
Rationale: USPSTF states insufficient evidence to recommend
routine testicular self-exam. However, high-risk individuals
(cryptorchidism, history) may be advised.
6. A 50-year-old woman has a BMI of 32, no comorbidities.
What is first-line therapy for weight loss?
A. Orlistat
B. Phentermine
C. Lifestyle modification (diet + exercise)
D. Bariatric surgery
Answer: C
Rationale: First-line treatment for overweight/obesity is
lifestyle modification (reduced calorie diet, increased physical
LEIK FNP Practice Questions and Answers.
1. A 55-year-old obese male with hypertension asks about
colorectal cancer screening. He has no family history. What
is the most appropriate initial test?
A. Colonoscopy every 10 years
B. Annual fecal immunochemical test (FIT)
C. CT colonography every 5 years
D. Flexible sigmoidoscopy every 5 years
Answer: B
Rationale: USPSTF recommends annual FIT, colonoscopy q10y,
or CT colonography q5y for average-risk adults 45–75. FIT is
noninvasive, easy, and a reasonable initial test. Shared
decision-making is key.
,Page 2 of 190
2. A 32-year-old G2P1 woman at 10 weeks gestation asks
about exercise. She ran marathons before pregnancy. What
is best advice?
A. Stop running to prevent preterm labor
B. Continue running but avoid overheating and dehydration
C. Switch to only walking after first trimester
D. Limit heart rate to <120 bpm
Answer: B
Rationale: ACOG encourages continuation of prepregnancy
exercise with precautions (hydration, avoid supine after 16
weeks, avoid trauma risk). No evidence that running causes
preterm labor.
3. Which vaccine is contraindicated in pregnancy?
A. Tdap
B. Influenza (inactivated)
C. MMR
D. Hepatitis B
,Page 3 of 190
Answer: C
Rationale: MMR is a live attenuated vaccine and is
contraindicated in pregnancy due to theoretical risk to the
fetus. Tdap (27–36 weeks), inactivated flu, and Hep B are
safe.
4. A 68-year-old woman with osteoporosis takes
alendronate. What counseling is most important?
A. Take with orange juice to enhance absorption
B. Remain upright for 30–60 minutes after dosing
C. Take at bedtime with food
D. Chew tablet for faster effect
Answer: B
Rationale: Alendronate can cause esophageal irritation and
ulceration. Patients must take it with a full glass of water on an
empty stomach and remain upright for 30–60 minutes.
5. A healthy 24-year-old male asks about testicular self-
exam. USPSTF recommendation?
, Page 4 of 190
A. Annual exam by provider only
B. Monthly self-exam for all males 15–35
C. Insufficient evidence to recommend routine self-exam
D. Self-exam only if family history of testicular cancer
Answer: C
Rationale: USPSTF states insufficient evidence to recommend
routine testicular self-exam. However, high-risk individuals
(cryptorchidism, history) may be advised.
6. A 50-year-old woman has a BMI of 32, no comorbidities.
What is first-line therapy for weight loss?
A. Orlistat
B. Phentermine
C. Lifestyle modification (diet + exercise)
D. Bariatric surgery
Answer: C
Rationale: First-line treatment for overweight/obesity is
lifestyle modification (reduced calorie diet, increased physical
