STUDENT C O M P A N I O N
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LIFE AT THE MOLECULAR LEVEL
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JOHN WILEY & SONS, INC
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Molecular structures clockwise from top: based on X-ray structures that were respectively
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Venki Ramakrishnan, MRC Laboratory of Molecular Biology, Cambridge, U.K.; Andrew
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Founded in 1807, John Wiley & Sons, Inc. has been a valued source of knowledge and
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(201) 748-6008, website http://www.wiley.com/go/permissions.
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Student Companion (paperback) ISBN-13
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Printed in the United States of
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pm America 10 pm p m 9 8 7pm pm p m 6 5 4 pm pm p m 3
pm 2 1
pm
, Contents
1 Introduction to the Chemistry of Life
pm pm pm pm pm 1
2 Water 9
3 Nucleotides, Nucleic Acids, and Genetic Information
pm pm pm pm pm 21
4 Amino Acids
pm 29
5 Proteins: Primary Structure
pm pm 40
6 Proteins: Three-Dimensional Structure
pm pm 49
7 Protein Function: Myoglobin and Hemoglobin, Muscle
pm pm pm pm pm
Contraction, and Antibodies
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8 Carbohydrates 72
9 Lipids and Biological Membranes
pm pm pm 80
10 Membrane Transport pm 90
11 Enzymatic Catalysis pm 96
12 Enzyme Kinetics, Inhibition, and Control
pm pm pm pm 108
13 Biochemical Signaling pm 121
14 Introduction to Metabolism pm pm 128
15 Glucose Catabolismpm 137
16 Glycogen Metabolism and Gluconeogenesis
pm pm pm 146
17 Citric Acid Cycle
pm pm 154
18 Electron Transport and Oxidative Phosphorylation
pm pm pm pm 160
F U N D A M
p m
E N T A L S O F
Biochemistry
LIFE AT pm
THE
p m MOLECULAR
LEVEL
m
p
Voet Voet Pratt
F O U R T H E D I T I O N
Akif Uzman Jerry Johnson Joseph Eichberg William Widger
pm p m pm pm
Donald Voet Judith G. Voet Charlotte W. Pratt
m
p pm pm pm pm pm
,STUDENT COMPANION TO ACCOMPANY pm pm pm
FUNDAMENTALS OF pm
BIOCHEMISTRY
LIFE AT THE MOLECULAR LEVEL
pm pm pm pm
Fourth Edition pm
Akif Uzman
pm
University of Houston pm pm
Jerry Johnson
pm
University of Houston pm pm
Joseph Eichberg pm
University of Houston pm pm
William Widger pm
University of Houston pm pm
Donald Voet pm
University of Pennsylvania
pm pm
Judith G. Voetpm pm
Swarthmore College pm
Charlotte W. Pratt pm pm
Seattle, Washingtonpm
JOHN WILEY & SONS, INC
pm pm pm pm
,Cover Designer Madelyn Lesure
pm pm pm
Cover Illustration Norm
pm pm pm
ChristiansenCover Photos
pm pm pm
(Vitruvian Man): © Odysseus/Alamy and © Dennis Hallinan/Alamy
pm pm pm pm pm pm pm
Molecular structures clockwise from top: based on X-ray structures that were respectively
pm pm pm pm pm pm pm pm pm pm pm
determined by Richard Dickerson and Horace Drew, Caltech; Gerard Bunick, University of
pm pm pm pm pm pm pm pm pm pm pm pm
Tennessee; Thomas Steitz, Yale University; Alfonso Mondragón, Northwestern University;
pm pm pm pm pm pm pm pm pm
Venki Ramakrishnan, MRC Laboratory of Molecular Biology, Cambridge, U.K.; Andrew
pm pm pm pm pm pm pm pm pm pm
Leslie and John Walker, MRC Laboratoryof Molecular Biology, Cambridge, U.K.
pm pm pm pm pm pm m
p pm pm pm pm
Founded in 1807, John Wiley & Sons, Inc. has been a valued source of knowledge and
pm pm pm pm pm pm pm pm pm pm pm pm pm pm pm
understanding for more than 200 years, helping people around the world meet their needs and
pm pm pm pm pm pm pm pm pm pm pm pm pm pm pm
fulfill their aspirations. Our company is built on a foundation of principles that include
pm pm pm pm pm pm pm pm pm pm pm pm pm pm
responsibility to the communities we serve and where we live and work. In 2008, we launched
pm pm pm pm pm pm pm pm pm pm pm pm pm pm pm pm
a Corporate Citizenship Initiative, a global effort to address the environmental, social,
pm pm pm pm pm pm pm pm pm pm pm pm
economic, and ethical challenges we face in our business. Among the issues we are
pm pm pm pm pm pm pm pm pm pm pm pm pm pm
addressing are carbon impact, paper specifications and procurement, ethical conduct within our
pm pm pm pm pm pm pm pm pm pm pm pm
business and among our vendors, and community and charitable support. For more
pm pm pm pm pm pm pm pm pm pm pm pm
information, please visit our website: www.wiley.com/go/citizenship.
pm pm pm pm pm pm
Copyright © 2012 pm pm John Wiley & Sons, Inc.
pm pm pm pm
All rights reserved. No part of this publication may be reproduced, stored in a retrieval
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system or transmitted in any form or by any means, electronic, mechanical, photocopying,
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recording, scanning or otherwise, except as permitted under Sections 107 or 108 of the 1976
pm pm pm pm pm pm pm pm pm pm pm pm pm pm pm
United States Copyright Act, without either the prior written permission of the Publisher, or
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authorization through payment of the appropriate per-copy fee to the Copyright Clearance
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Center, Inc., 222 Rosewood Drive, Danvers, MA 01923, website www.copyright.com.
pm pm pm pm pm pm pm pm pm pm
Requests to the Publisher for permission should be addressed to the Permissions Department,
pm pm pm pm pm pm pm pm pm pm pm m
p pm
John Wiley & Sons, Inc. 111 River Street, Hoboken, NJ 07030-5774, (201) 748-6011, fax
pm pm pm pm pm pm pm pm pm pm pm pm pm pm
(201) 748-6008, website http://www.wiley.com/go/permissions.
pm pm pm pm
To order books or for customer service, please call 1-800-CALL WILEY (225-5945).
pm pm pm pm pm pm pm pm pm pm pm
Student Companion (paperback) ISBN-13
pm pm p m 978-1-1182-1827-3
Printed in the United States of
pm pm pm pm pm
pm America 10 pm p m 9 8 7pm pm p m 6 5 4 pm pm p m 3
pm 2 1
pm
, Contents
1 Introduction to the Chemistry of Life
pm pm pm pm pm 1
2 Water 9
3 Nucleotides, Nucleic Acids, and Genetic Information
pm pm pm pm pm 21
4 Amino Acids
pm 29
5 Proteins: Primary Structure
pm pm 40
6 Proteins: Three-Dimensional Structure
pm pm 49
7 Protein Function: Myoglobin and Hemoglobin, Muscle
pm pm pm pm pm
Contraction, and Antibodies
pm pm pm 60
8 Carbohydrates 72
9 Lipids and Biological Membranes
pm pm pm 80
10 Membrane Transport pm 90
11 Enzymatic Catalysis pm 96
12 Enzyme Kinetics, Inhibition, and Control
pm pm pm pm 108
13 Biochemical Signaling pm 121
14 Introduction to Metabolism pm pm 128
15 Glucose Catabolismpm 137
16 Glycogen Metabolism and Gluconeogenesis
pm pm pm 146
17 Citric Acid Cycle
pm pm 154
18 Electron Transport and Oxidative Phosphorylation
pm pm pm pm 160
