1
Antifungals Med chem ++ Questions
and Answers (100% Correct
Answers) Already Graded A+
Naturally occurring Ans: Antifungal ABX
© 2026 Assignment
- mostly produced by Actinomycetes, classified as ‘higher
bacteria’
Guru01 - Stuvia
Expert
- Ex: Amphotericin B (AMB), a polyene antimycotic, Nystatin
Antifungals of fungal origin.
- Ex: Griseofulvin, a Heterocyclic Benzofuran discovered in
1939 from a type of Penicillium mold
Synthetic Agents: Ans: Azoles:
- Imidazoles: Clotrimazole, Econazole, Miconazole,
Oxiconazole, Ketoconazole;
- Triazoles: Fluconazole, Itraconazole, Voriconazole,
Efinaconazole;
- Tetrazoles: Oteseconazole
Anti-metabolites: Flucytosine (5-FC)
Allylamine:
, 2
- Ex: Terbinafine (Lamisil), Butenafine (Lotrimin Ultra),
Naftifine (Naftin), Tolnaftate
Newest antifungals (Echinocandins):
- Ex: Caspofungin, Micafungin, Anidulafungin
Others:
- Ex: Ciclopirox, tavaborole
© 2026 Assignment
Diseases caused by fungi are mainly due to the Ans:
Guru01 - Stuvia
Microsporum (A), Trichophyton (B) or Epidermophyton (C)
Expert
genera.
Overview of fungi: Ans: - non-motile eukaryotic single-celled
or multinucleate organisms (parasitic in nature)
- can cause superficial infections of the skin with red itchy
lesions & deep and invasive systemic infections, especially in
persons with reduced immunity.
- Usually mild and become serious or threatening only in those
with a weakened immune system.
Types of fungal infections: Superficial Ans: Infection caused
by dermatophytes (tinea or ringworm infection):
- Athlete's foot (tinea pedis)
- Barber's itch occurring in the beard (tinea barbae)
- Jock itch (tinea cruris)
, 3
- Scalp infection (tinea capitis)
- Hand infection (tinea manuum)
- Infection in other parts of the body (tinea corporis)
- Nail bed infection (tinea unguium)
Cutaneous yeast or Candida infection:
© 2026 Assignment
- Armpits, groin and underneath body folds.
Guru01 - Stuvia
- Other yeast infections: oral thrush occurring in the mouth,
Expert
vaginal yeast infections (also referred to as moniliasis) in
women and fungal diaper or nappy rash in babies.
Types of fungal infections: Deep or systemic Fungal Infection
Ans: - invasive aspergillosis
- systemic candidiasis
- mucormycosis
- cryptococcosis
- histoplasmosis;blastomycosis
- coccidioidomycosis
- paracoccidioidomycosis
Antifungals: MOA Ans: act on the
, 4
- synthesis of membrane or wall components
- membrane permeability
- synthesis of nucleic acids and on the mitotic spindle function
of the fungi during cell division.
Main target for antifungals: ergosterol
Synthetic Agents: Azoles Ans: Imidazoles:
© 2026 Assignment
- Clotrimazole
Guru01 - Stuvia
Expert
- Econazole
- Miconazole
- Oxiconazole
- Ketoconazole
Triazoles:
- Fluconazole
- Itraconazole
- Voriconazole
- Efinaconazole
Tetrazoles:
Antifungals Med chem ++ Questions
and Answers (100% Correct
Answers) Already Graded A+
Naturally occurring Ans: Antifungal ABX
© 2026 Assignment
- mostly produced by Actinomycetes, classified as ‘higher
bacteria’
Guru01 - Stuvia
Expert
- Ex: Amphotericin B (AMB), a polyene antimycotic, Nystatin
Antifungals of fungal origin.
- Ex: Griseofulvin, a Heterocyclic Benzofuran discovered in
1939 from a type of Penicillium mold
Synthetic Agents: Ans: Azoles:
- Imidazoles: Clotrimazole, Econazole, Miconazole,
Oxiconazole, Ketoconazole;
- Triazoles: Fluconazole, Itraconazole, Voriconazole,
Efinaconazole;
- Tetrazoles: Oteseconazole
Anti-metabolites: Flucytosine (5-FC)
Allylamine:
, 2
- Ex: Terbinafine (Lamisil), Butenafine (Lotrimin Ultra),
Naftifine (Naftin), Tolnaftate
Newest antifungals (Echinocandins):
- Ex: Caspofungin, Micafungin, Anidulafungin
Others:
- Ex: Ciclopirox, tavaborole
© 2026 Assignment
Diseases caused by fungi are mainly due to the Ans:
Guru01 - Stuvia
Microsporum (A), Trichophyton (B) or Epidermophyton (C)
Expert
genera.
Overview of fungi: Ans: - non-motile eukaryotic single-celled
or multinucleate organisms (parasitic in nature)
- can cause superficial infections of the skin with red itchy
lesions & deep and invasive systemic infections, especially in
persons with reduced immunity.
- Usually mild and become serious or threatening only in those
with a weakened immune system.
Types of fungal infections: Superficial Ans: Infection caused
by dermatophytes (tinea or ringworm infection):
- Athlete's foot (tinea pedis)
- Barber's itch occurring in the beard (tinea barbae)
- Jock itch (tinea cruris)
, 3
- Scalp infection (tinea capitis)
- Hand infection (tinea manuum)
- Infection in other parts of the body (tinea corporis)
- Nail bed infection (tinea unguium)
Cutaneous yeast or Candida infection:
© 2026 Assignment
- Armpits, groin and underneath body folds.
Guru01 - Stuvia
- Other yeast infections: oral thrush occurring in the mouth,
Expert
vaginal yeast infections (also referred to as moniliasis) in
women and fungal diaper or nappy rash in babies.
Types of fungal infections: Deep or systemic Fungal Infection
Ans: - invasive aspergillosis
- systemic candidiasis
- mucormycosis
- cryptococcosis
- histoplasmosis;blastomycosis
- coccidioidomycosis
- paracoccidioidomycosis
Antifungals: MOA Ans: act on the
, 4
- synthesis of membrane or wall components
- membrane permeability
- synthesis of nucleic acids and on the mitotic spindle function
of the fungi during cell division.
Main target for antifungals: ergosterol
Synthetic Agents: Azoles Ans: Imidazoles:
© 2026 Assignment
- Clotrimazole
Guru01 - Stuvia
Expert
- Econazole
- Miconazole
- Oxiconazole
- Ketoconazole
Triazoles:
- Fluconazole
- Itraconazole
- Voriconazole
- Efinaconazole
Tetrazoles:
