NU 641 Advanced Pharm (for NPs) Vaccines Exam Study Guide

NU 641 Advanced Pharm (for NPs) Vaccines Exam Study Guide Live Attenuated vaccines general principles - Answer-Not administered to immunocompromised patients Usually not given if patient has febrile illness If patient needs two live vaccines: - Answer-Give both the same day OR Administer at least 4 weeks apart Can live attenuated vaccine be administered in pregnancy? - Answer-Not administered in pregnancy Pregnancy should be avoid for 1 month after vaccination Drug interaction with live attenuated vaccine? - Answer-Antiviral drugs List of live attenuated vaccines? - Answer-Live Attenuated Influenza Vaccine (Flumist) Measles, Mumps, and Rubella Vaccine (MMR) Oral Poliovirus Vaccine (OPV) -no longer used in US Rotavirus Vaccine (Rotarix, RotaTeq) Varicella Virus Vaccine (Varivax, ProQuad) EMILLECT 2024/2025 ACADEMIC YEAR ©2024 EMILLECT. ALL RIGHTS RESERVED FIRST PUBLISH OCTOBER, 2024 Page 2/14 Herpes Zoster Vaccine (Zostavax) LAIV (Flumist) what are the two types of live Attenuated Influenza Vaccine? - Answer-Was trivalent and Quadrivalent (February 2012) flu season only available as Quadrivalent Trivalent - - Answer-Contains 2 strains of Influenza A and 1 strain of influenza B Quadrivalent - - Answer-Contains 2 strains of Influenza A and 2 strains of influenza B How is LAIV (Flumist) administered? - Answer-Administered intranasally (half in each nostril) Live vaccine replicates in nasal mucosa Administer to healthy patients age 2 yrs to 49 yrs annually Children age 2 to 8 years need typically need 2 doses (4 weeks apart) 1st year - refer to guidelines LAIV (Flumist) contraindications? - Answer-Contraindicated: Egg allergy, asthma, immunocompromised, pregnancy, lactation (possibility of viral shed in breast milk) Measles, Mumps & Rubella (MMR) - Answer-2 doses 99% effective in providing immunity Contraindications for MMR: - Answer-neomycin or gelatin allergy, pregnancy (within 3 months of vaccine), immunosuppression, febrile illness May be given to close contact of immunosuppressed patients EMILLECT 2024/2025 ACADEMIC YEAR ©2024 EMILLECT. ALL RIGHTS RESERVED FIRST PUBLISH OCTOBER, 2024 Page 3/14 Wait 3 months from receiving blood products can MMR be given to pt with egg allergy? - Answer-Ok to give with egg allergy MMR and breastfeeding - Answer-May give to breastfeeding women ADRs of MMR - Answer-Fever 7 to 12 days after vaccination Transient maculopapular rash 7-10 days after vaccination in 5% of patients MMR drug interactions - Answer-Immunosupressents including high dose corticosteroids and chemotherapy Immune globulin - can inactivate vaccine PPD - delayed 4 to 6 weeks after MMR - - may interfere with the tuberculin skin test At what age is first MMR administered? - Answer-Administer first dos