Introduction to Pharmacology - GCU
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,What nursing considerations should be taken when administering Diphenhydramine
(Benadryl)?
Correct Answer:
Avoid use with alcohol or CNS depressants; educate about drowsiness; avoid driving
Expert Rationale:
Diphenhydramine, a first-generation antihistamine, readily crosses the blood-brain
barrier, leading to pronounced CNS depression and sedation. Concomitant use with
alcohol or other CNS depressants potentiates these effects, significantly increasing fall
and accident risk. Patient education about potential drowsiness and the imperative to
avoid driving or operating heavy machinery is essential to safeguard patient safety
and prevent adverse events.
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Is Diphenhydramine (Benadryl) recommended for neonates or patients with acute
asthma?
Correct Answer:
Not recommended
Expert Rationale:
,In neonates, diphenhydramine is associated with an increased risk of severe
respiratory depression and paradoxical CNS excitation, making its use contraindicated
in this age group. In patients with acute asthma, anticholinergic and drying effects can
thicken bronchial secretions, exacerbating airway obstruction and worsening
respiratory status. Evidence-based guidelines uniformly advise against its use in these
populations.
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What is the class of Dextromethorphan?
Correct Answer:
Antitussive
Expert Rationale:
Dextromethorphan is classified as a centrally acting antitussive agent. Its primary
therapeutic use is to suppress cough by modulating neural pathways in the brainstem.
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What is the indication for Dextromethorphan?
Correct Answer:
Nonproductive cough
, Expert Rationale:
Dextromethorphan is indicated for the management of nonproductive, dry cough to
improve comfort and reduce unnecessary energy expenditure due to coughing,
without impairing airway clearance of secretions needed in productive cough.
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What is the mechanism of action of Dextromethorphan?
Correct Answer:
Acts on cough center in medulla to suppress cough reflex
Expert Rationale:
Dextromethorphan suppresses the cough reflex by acting directly on the medullary
cough center in the central nervous system, thus diminishing the urge to cough.
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What are key side effects of Dextromethorphan?
Correct Answer:
Drowsiness, dizziness, nausea