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Principles of Development résumés
Lewis Wolpert, Jim Smith - ISBN: 9780198800569
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Afficher tous les 26 résumés de Principles of Development, écrits par Lewis Wolpert, Jim Smith. Les résumés de Principles of Development sur Stuvia sont écrits par des étudiants ou des enseignants, ce qui facilite et accélère la compréhension du contenu du manuel. Trouver le résumé qui correspond parfaitement à votre style d'apprentissage rendra l'étude beaucoup plus facile.
Résumés les plus vendus pour Principles of Development
Summary of the lectures, (theory of) Q&A’s, computer practicals, and the textbook, which can be used for the exam preparations
- Resume
- • 27 pages •
Summary of the lectures, (theory of) Q&A’s, computer practicals, and the textbook, which can be used for the exam preparations
-Describe the hierarchy of gene activity that regulates Drosophila segmentation
-Distinguish and explain methods used to investigate protein vs mRNA expression
-Describe the syncytial nature of the early stages of fly development and understand its significance.
-Understand and describe at the molecular level how the Gap genes regulate the expression of Eve stripe 2
-Make predictions about segment polarity gene expression in a pair-rule mutant embryo or about pair-rule gene expression in a Gap m...
- Notes de cours
- • 7 pages •
-Describe the hierarchy of gene activity that regulates Drosophila segmentation
-Distinguish and explain methods used to investigate protein vs mRNA expression
-Describe the syncytial nature of the early stages of fly development and understand its significance.
-Understand and describe at the molecular level how the Gap genes regulate the expression of Eve stripe 2
-Make predictions about segment polarity gene expression in a pair-rule mutant embryo or about pair-rule gene expression in a Gap m...
- Appreciate and describe the molecular mechanisms underlying neural induction
- Describe TGF-beta (TGF-β) signal transduction and the differences between the BMP versus nodal pathways
- Discuss the experiments that demonstrate a role for BMP antagonists in vertebrate neural induction
- Describe how antisense morpholino oligos can be used to inhibit gene function
- Appreciate and describe the differences between the processes of neural induction versus neurogenesis
- Notes de cours
- • 6 pages •
- Appreciate and describe the molecular mechanisms underlying neural induction
- Describe TGF-beta (TGF-β) signal transduction and the differences between the BMP versus nodal pathways
- Discuss the experiments that demonstrate a role for BMP antagonists in vertebrate neural induction
- Describe how antisense morpholino oligos can be used to inhibit gene function
- Appreciate and describe the differences between the processes of neural induction versus neurogenesis
- Identify the important signalling centres in the developing limb bud and describe the experiments that identified these centres and demonstrated their importance.
- Describe the experimental evidence for the role of FGF signalling in limb bud outgrowth
- Describe the experimental evidence that shows that Shh acts as a morphogen to pattern the anterior-posterior axis of the limb bud.
- Describe how the important signalling centres in the limb bud co-ordinately regulate pattern formation in the ...
- Notes de cours
- • 7 pages •
- Identify the important signalling centres in the developing limb bud and describe the experiments that identified these centres and demonstrated their importance.
- Describe the experimental evidence for the role of FGF signalling in limb bud outgrowth
- Describe the experimental evidence that shows that Shh acts as a morphogen to pattern the anterior-posterior axis of the limb bud.
- Describe how the important signalling centres in the limb bud co-ordinately regulate pattern formation in the ...
- Provide an overview of the polycomb and trithorax group complexes and their activities
- Describe evidence that indicates stem cell chromatin is in an open ‘permissive’ state
- Understand what is bivalent chromatin and why it may be important for stem cell biology and development
- Understand the steps of chromatin immunoprecipitation and why it is a useful technique in epigenetic studies
- Describe the Nodal signalling example and experimental approach, and understand how it illustrates ...
- Notes de cours
- • 9 pages •
- Provide an overview of the polycomb and trithorax group complexes and their activities
- Describe evidence that indicates stem cell chromatin is in an open ‘permissive’ state
- Understand what is bivalent chromatin and why it may be important for stem cell biology and development
- Understand the steps of chromatin immunoprecipitation and why it is a useful technique in epigenetic studies
- Describe the Nodal signalling example and experimental approach, and understand how it illustrates ...
- Discuss the evidence for the nodal morphogen acting during mesoderm induction.
- Discuss the concept of the vertebrate dorsal organiser.
- Discuss the evidence that the brachyury transcription factor is a conserved regulator of germ layer specification.
- Draw conclusions regarding the molecular pathways regulating development of Urbilateria.
- Notes de cours
- • 8 pages •
- Discuss the evidence for the nodal morphogen acting during mesoderm induction.
- Discuss the concept of the vertebrate dorsal organiser.
- Discuss the evidence that the brachyury transcription factor is a conserved regulator of germ layer specification.
- Draw conclusions regarding the molecular pathways regulating development of Urbilateria.
- To give an overview of genomic imprinting, when it is initiated and how imprinting disorders can arise
- Describe key events in X-inactivation including the role of the Xist non-coding RNA
- Notes de cours
- • 8 pages •
- To give an overview of genomic imprinting, when it is initiated and how imprinting disorders can arise
- Describe key events in X-inactivation including the role of the Xist non-coding RNA
- To have gained an understanding of why epigenetics is relevant to development
- To understand that DNA methylation can impact gene expression and be able to describe an experimental approach to test this
- To explain how patterns of DNA methylation can be maintained through DNA replication
- To understand that covalent histone modifications form a code that can impact gene expression
- To explain how some histone modifications can be maintained through DNA replication
- Notes de cours
- • 10 pages •
- To have gained an understanding of why epigenetics is relevant to development
- To understand that DNA methylation can impact gene expression and be able to describe an experimental approach to test this
- To explain how patterns of DNA methylation can be maintained through DNA replication
- To understand that covalent histone modifications form a code that can impact gene expression
- To explain how some histone modifications can be maintained through DNA replication
- Discuss the evidence supporting a role for tinman homologues in heart development
- Discuss the anatomical and molecular evidence supporting the theory of dorsoventral axis inversion during the evolution of protostome and deuterostome lineages.
- Describe the conserved features of Hox gene cluster organisation.
- Appreciate and discuss how changes in the expression and activity of Hox genes have contributed to changes in anatomy during animal evolution.
- Draw conclusions regarding the molecul...
- Notes de cours
- • 7 pages •
- Discuss the evidence supporting a role for tinman homologues in heart development
- Discuss the anatomical and molecular evidence supporting the theory of dorsoventral axis inversion during the evolution of protostome and deuterostome lineages.
- Describe the conserved features of Hox gene cluster organisation.
- Appreciate and discuss how changes in the expression and activity of Hox genes have contributed to changes in anatomy during animal evolution.
- Draw conclusions regarding the molecul...
Test Bank For Principles of Development 6th Edition By Lewis Wolpert; Cheryll Tickle; Alfonso Martinez Arias 0569, 8 . 2993, X 
 
1 History and basic concepts 
 
2 Development of the Drosophila body plan 
 
3 Vertebrate development I: life cycles and experimental techniques 
 
4 Vertebrate development II: Xenopus and zebrafish 
 
5 Vertebrate development III: chick and mouse—completing the body plan 
 
6 Development of nematodes and sea urchins 
 
7 Morphogenesis: change in form in the early e...
- Examen
- • 257 pages •
Test Bank For Principles of Development 6th Edition By Lewis Wolpert; Cheryll Tickle; Alfonso Martinez Arias 0569, 8 . 2993, X 
 
1 History and basic concepts 
 
2 Development of the Drosophila body plan 
 
3 Vertebrate development I: life cycles and experimental techniques 
 
4 Vertebrate development II: Xenopus and zebrafish 
 
5 Vertebrate development III: chick and mouse—completing the body plan 
 
6 Development of nematodes and sea urchins 
 
7 Morphogenesis: change in form in the early e...
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Derniers résumés de Principles of Development
- Understand how the neural crest contributes to cardiac development and the pathology underlying congenital cardiac abnormalities.
- Explain how certain SNPs might contribute to congenital abnormalities.
- Discuss the evidence that Notch signalling is important during cardiac morphogenesis
- Notes de cours
- • 10 pages •
- Understand how the neural crest contributes to cardiac development and the pathology underlying congenital cardiac abnormalities.
- Explain how certain SNPs might contribute to congenital abnormalities.
- Discuss the evidence that Notch signalling is important during cardiac morphogenesis
-Describe the hierarchy of gene activity that regulates Drosophila segmentation
-Distinguish and explain methods used to investigate protein vs mRNA expression
-Describe the syncytial nature of the early stages of fly development and understand its significance.
-Understand and describe at the molecular level how the Gap genes regulate the expression of Eve stripe 2
-Make predictions about segment polarity gene expression in a pair-rule mutant embryo or about pair-rule gene expression in a Gap m...
- Notes de cours
- • 7 pages •
-Describe the hierarchy of gene activity that regulates Drosophila segmentation
-Distinguish and explain methods used to investigate protein vs mRNA expression
-Describe the syncytial nature of the early stages of fly development and understand its significance.
-Understand and describe at the molecular level how the Gap genes regulate the expression of Eve stripe 2
-Make predictions about segment polarity gene expression in a pair-rule mutant embryo or about pair-rule gene expression in a Gap m...
-Describe and interpret the embryological experiments that demonstrated a role for the notochord and floorplate in motor neuron induction.
-Describe and interpret the experiments that show Shh acts as a morphogen to pattern the ventral neural tube. 
-Be able to explain the concept of morphogen using examples.
-Describe the Shh signal transduction pathway.
- Notes de cours
- • 7 pages •
-Describe and interpret the embryological experiments that demonstrated a role for the notochord and floorplate in motor neuron induction.
-Describe and interpret the experiments that show Shh acts as a morphogen to pattern the ventral neural tube. 
-Be able to explain the concept of morphogen using examples.
-Describe the Shh signal transduction pathway.
- Appreciate and describe the molecular mechanisms underlying neural induction
- Describe TGF-beta (TGF-β) signal transduction and the differences between the BMP versus nodal pathways
- Discuss the experiments that demonstrate a role for BMP antagonists in vertebrate neural induction
- Describe how antisense morpholino oligos can be used to inhibit gene function
- Appreciate and describe the differences between the processes of neural induction versus neurogenesis
- Notes de cours
- • 6 pages •
- Appreciate and describe the molecular mechanisms underlying neural induction
- Describe TGF-beta (TGF-β) signal transduction and the differences between the BMP versus nodal pathways
- Discuss the experiments that demonstrate a role for BMP antagonists in vertebrate neural induction
- Describe how antisense morpholino oligos can be used to inhibit gene function
- Appreciate and describe the differences between the processes of neural induction versus neurogenesis
- Identify the important signalling centres in the developing limb bud and describe the experiments that identified these centres and demonstrated their importance.
- Describe the experimental evidence for the role of FGF signalling in limb bud outgrowth
- Describe the experimental evidence that shows that Shh acts as a morphogen to pattern the anterior-posterior axis of the limb bud.
- Describe how the important signalling centres in the limb bud co-ordinately regulate pattern formation in the ...
- Notes de cours
- • 7 pages •
- Identify the important signalling centres in the developing limb bud and describe the experiments that identified these centres and demonstrated their importance.
- Describe the experimental evidence for the role of FGF signalling in limb bud outgrowth
- Describe the experimental evidence that shows that Shh acts as a morphogen to pattern the anterior-posterior axis of the limb bud.
- Describe how the important signalling centres in the limb bud co-ordinately regulate pattern formation in the ...
- Explain the significance of the neural crest lineage to vertebrate anatomy.
- Distinguish the ventral-lateral and dorsal pathways of neural crest migration.
- Give examples of cell types derived from specific AP regions of neural crest. 
- Describe and interpret experiments used to ‘fate map’ neural crest cells in avian embryos.
- Describe and interpret experiments used to determine the developmental potential of neural crest cells in avian embryos.
- Notes de cours
- • 7 pages •
- Explain the significance of the neural crest lineage to vertebrate anatomy.
- Distinguish the ventral-lateral and dorsal pathways of neural crest migration.
- Give examples of cell types derived from specific AP regions of neural crest. 
- Describe and interpret experiments used to ‘fate map’ neural crest cells in avian embryos.
- Describe and interpret experiments used to determine the developmental potential of neural crest cells in avian embryos.
- Provide an overview of the polycomb and trithorax group complexes and their activities
- Describe evidence that indicates stem cell chromatin is in an open ‘permissive’ state
- Understand what is bivalent chromatin and why it may be important for stem cell biology and development
- Understand the steps of chromatin immunoprecipitation and why it is a useful technique in epigenetic studies
- Describe the Nodal signalling example and experimental approach, and understand how it illustrates ...
- Notes de cours
- • 9 pages •
- Provide an overview of the polycomb and trithorax group complexes and their activities
- Describe evidence that indicates stem cell chromatin is in an open ‘permissive’ state
- Understand what is bivalent chromatin and why it may be important for stem cell biology and development
- Understand the steps of chromatin immunoprecipitation and why it is a useful technique in epigenetic studies
- Describe the Nodal signalling example and experimental approach, and understand how it illustrates ...
- Discuss the evidence for the nodal morphogen acting during mesoderm induction.
- Discuss the concept of the vertebrate dorsal organiser.
- Discuss the evidence that the brachyury transcription factor is a conserved regulator of germ layer specification.
- Draw conclusions regarding the molecular pathways regulating development of Urbilateria.
- Notes de cours
- • 8 pages •
- Discuss the evidence for the nodal morphogen acting during mesoderm induction.
- Discuss the concept of the vertebrate dorsal organiser.
- Discuss the evidence that the brachyury transcription factor is a conserved regulator of germ layer specification.
- Draw conclusions regarding the molecular pathways regulating development of Urbilateria.
- To give an overview of genomic imprinting, when it is initiated and how imprinting disorders can arise
- Describe key events in X-inactivation including the role of the Xist non-coding RNA
- Notes de cours
- • 8 pages •
- To give an overview of genomic imprinting, when it is initiated and how imprinting disorders can arise
- Describe key events in X-inactivation including the role of the Xist non-coding RNA
- Discuss the evidence supporting a role for tinman homologues in heart development
- Discuss the anatomical and molecular evidence supporting the theory of dorsoventral axis inversion during the evolution of protostome and deuterostome lineages.
- Describe the conserved features of Hox gene cluster organisation.
- Appreciate and discuss how changes in the expression and activity of Hox genes have contributed to changes in anatomy during animal evolution.
- Draw conclusions regarding the molecul...
- Notes de cours
- • 7 pages •
- Discuss the evidence supporting a role for tinman homologues in heart development
- Discuss the anatomical and molecular evidence supporting the theory of dorsoventral axis inversion during the evolution of protostome and deuterostome lineages.
- Describe the conserved features of Hox gene cluster organisation.
- Appreciate and discuss how changes in the expression and activity of Hox genes have contributed to changes in anatomy during animal evolution.
- Draw conclusions regarding the molecul...
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