The University of York (UOY) • Biology
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Biology BIOL1000 1
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Molecular Genetics and Development BIO00052I 15
Dernières notes et résumés The University of York (UOY) • Biology
- To give an overview of genomic imprinting, when it is initiated and how imprinting disorders can arise
- Describe key events in X-inactivation including the role of the Xist non-coding RNA
- Book
- Notes de cours
- • 8 pages's •
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The University of York•Molecular Genetics and Development
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Principles of Development • Lewis Wolpert, Jim Smith• ISBN 9780198800569
Aperçu 2 sur 8 pages
- To give an overview of genomic imprinting, when it is initiated and how imprinting disorders can arise
- Describe key events in X-inactivation including the role of the Xist non-coding RNA
- Discuss the evidence for the nodal morphogen acting during mesoderm induction.
- Discuss the concept of the vertebrate dorsal organiser.
- Discuss the evidence that the brachyury transcription factor is a conserved regulator of germ layer specification.
- Draw conclusions regarding the molecular pathways regulating development of Urbilateria.
- Book
- Notes de cours
- • 8 pages's •
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The University of York•Molecular Genetics and Development
-
Principles of Development • Lewis Wolpert, Jim Smith• ISBN 9780198800569
Aperçu 2 sur 8 pages
- Discuss the evidence for the nodal morphogen acting during mesoderm induction.
- Discuss the concept of the vertebrate dorsal organiser.
- Discuss the evidence that the brachyury transcription factor is a conserved regulator of germ layer specification.
- Draw conclusions regarding the molecular pathways regulating development of Urbilateria.
- Provide an overview of the polycomb and trithorax group complexes and their activities
- Describe evidence that indicates stem cell chromatin is in an open ‘permissive’ state
- Understand what is bivalent chromatin and why it may be important for stem cell biology and development
- Understand the steps of chromatin immunoprecipitation and why it is a useful technique in epigenetic studies
- Describe the Nodal signalling example and experimental approach, and understand how it illustrates ...
- Book
- Notes de cours
- • 9 pages's •
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The University of York•Molecular Genetics and Development
-
Principles of Development • Lewis Wolpert, Jim Smith• ISBN 9780198800569
Aperçu 2 sur 9 pages
- Provide an overview of the polycomb and trithorax group complexes and their activities
- Describe evidence that indicates stem cell chromatin is in an open ‘permissive’ state
- Understand what is bivalent chromatin and why it may be important for stem cell biology and development
- Understand the steps of chromatin immunoprecipitation and why it is a useful technique in epigenetic studies
- Describe the Nodal signalling example and experimental approach, and understand how it illustrates ...
- Describe experiments that defined compartments of cell lineage restriction.
- Define a compartment and describe the evidence showing that the parasegment is a compartment and the developmentally important unit of the fly.
- Describe genetic experiments demonstrating that HOM-C genes regulate parasegment identity in Drosophila.
- Evaluate whether the vertebrate Hox genes share a conserved function with Drosophila HomC genes
- Book
- Notes de cours
- • 8 pages's •
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The University of York•Molecular Genetics and Development
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Principles of Development • Lewis Wolpert, Cheryll Tickle• ISBN 9780199678143
Aperçu 2 sur 8 pages
- Describe experiments that defined compartments of cell lineage restriction.
- Define a compartment and describe the evidence showing that the parasegment is a compartment and the developmentally important unit of the fly.
- Describe genetic experiments demonstrating that HOM-C genes regulate parasegment identity in Drosophila.
- Evaluate whether the vertebrate Hox genes share a conserved function with Drosophila HomC genes
- Identify the important signalling centres in the developing limb bud and describe the experiments that identified these centres and demonstrated their importance.
- Describe the experimental evidence for the role of FGF signalling in limb bud outgrowth
- Describe the experimental evidence that shows that Shh acts as a morphogen to pattern the anterior-posterior axis of the limb bud.
- Describe how the important signalling centres in the limb bud co-ordinately regulate pattern formation in the ...
- Book
- Notes de cours
- • 7 pages's •
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The University of York•Molecular Genetics and Development
-
Principles of Development • Lewis Wolpert, Jim Smith• ISBN 9780198800569
Aperçu 2 sur 7 pages
- Identify the important signalling centres in the developing limb bud and describe the experiments that identified these centres and demonstrated their importance.
- Describe the experimental evidence for the role of FGF signalling in limb bud outgrowth
- Describe the experimental evidence that shows that Shh acts as a morphogen to pattern the anterior-posterior axis of the limb bud.
- Describe how the important signalling centres in the limb bud co-ordinately regulate pattern formation in the ...
- Appreciate and describe the molecular mechanisms underlying neural induction
- Describe TGF-beta (TGF-β) signal transduction and the differences between the BMP versus nodal pathways
- Discuss the experiments that demonstrate a role for BMP antagonists in vertebrate neural induction
- Describe how antisense morpholino oligos can be used to inhibit gene function
- Appreciate and describe the differences between the processes of neural induction versus neurogenesis
- Book
- Notes de cours
- • 6 pages's •
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The University of York•Molecular Genetics and Development
-
Principles of Development • Lewis Wolpert, Jim Smith• ISBN 9780198800569
Aperçu 2 sur 6 pages
- Appreciate and describe the molecular mechanisms underlying neural induction
- Describe TGF-beta (TGF-β) signal transduction and the differences between the BMP versus nodal pathways
- Discuss the experiments that demonstrate a role for BMP antagonists in vertebrate neural induction
- Describe how antisense morpholino oligos can be used to inhibit gene function
- Appreciate and describe the differences between the processes of neural induction versus neurogenesis
-Describe the hierarchy of gene activity that regulates Drosophila segmentation
-Distinguish and explain methods used to investigate protein vs mRNA expression
-Describe the syncytial nature of the early stages of fly development and understand its significance.
-Understand and describe at the molecular level how the Gap genes regulate the expression of Eve stripe 2
-Make predictions about segment polarity gene expression in a pair-rule mutant embryo or about pair-rule gene expression in a Gap m...
- Book
- Notes de cours
- • 7 pages's •
-
The University of York•Molecular Genetics and Development
-
Principles of Development • Lewis Wolpert, Jim Smith• ISBN 9780198800569
Aperçu 2 sur 7 pages
-Describe the hierarchy of gene activity that regulates Drosophila segmentation
-Distinguish and explain methods used to investigate protein vs mRNA expression
-Describe the syncytial nature of the early stages of fly development and understand its significance.
-Understand and describe at the molecular level how the Gap genes regulate the expression of Eve stripe 2
-Make predictions about segment polarity gene expression in a pair-rule mutant embryo or about pair-rule gene expression in a Gap m...
- Understand how the neural crest contributes to cardiac development and the pathology underlying congenital cardiac abnormalities.
- Explain how certain SNPs might contribute to congenital abnormalities.
- Discuss the evidence that Notch signalling is important during cardiac morphogenesis
- Book
- Notes de cours
- • 10 pages's •
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The University of York•Molecular Genetics and Development
-
Principles of Development • Lewis Wolpert, Jim Smith• ISBN 9780198800569
Aperçu 2 sur 10 pages
- Understand how the neural crest contributes to cardiac development and the pathology underlying congenital cardiac abnormalities.
- Explain how certain SNPs might contribute to congenital abnormalities.
- Discuss the evidence that Notch signalling is important during cardiac morphogenesis
- Discuss the evidence supporting a role for tinman homologues in heart development
- Discuss the anatomical and molecular evidence supporting the theory of dorsoventral axis inversion during the evolution of protostome and deuterostome lineages.
- Describe the conserved features of Hox gene cluster organisation.
- Appreciate and discuss how changes in the expression and activity of Hox genes have contributed to changes in anatomy during animal evolution.
- Draw conclusions regarding the molecul...
- Book
- Notes de cours
- • 7 pages's •
-
The University of York•Molecular Genetics and Development
-
Principles of Development • Lewis Wolpert, Jim Smith• ISBN 9780198800569
Aperçu 2 sur 7 pages
- Discuss the evidence supporting a role for tinman homologues in heart development
- Discuss the anatomical and molecular evidence supporting the theory of dorsoventral axis inversion during the evolution of protostome and deuterostome lineages.
- Describe the conserved features of Hox gene cluster organisation.
- Appreciate and discuss how changes in the expression and activity of Hox genes have contributed to changes in anatomy during animal evolution.
- Draw conclusions regarding the molecul...
- Describe the different types of animal body symmetry and the main body axes of bilaterally symmetrical animals.
- Describe the features that define diploblasts versus triploblasts.
- Describe the features that define protostomes versus deuterostomes.
- Understand the importance of the Ediacaran and Cambrian fauna in animal evolution.	
- Describe the common features of phylotypic stage chordate embryos.
- Discuss the evidence indicating that Pax6 is a conserved regulator of eye development. 
- ...
- Book
- Notes de cours
- • 7 pages's •
-
The University of York•Molecular Genetics and Development
-
Principles of Development • Lewis Wolpert, Jim Smith• ISBN 9780198800569
Aperçu 2 sur 7 pages
- Describe the different types of animal body symmetry and the main body axes of bilaterally symmetrical animals.
- Describe the features that define diploblasts versus triploblasts.
- Describe the features that define protostomes versus deuterostomes.
- Understand the importance of the Ediacaran and Cambrian fauna in animal evolution.	
- Describe the common features of phylotypic stage chordate embryos.
- Discuss the evidence indicating that Pax6 is a conserved regulator of eye development. 
- ...