Summary, From molecule to mind
Table of Contents
NeuroAnatomy ................................................................................................................... 3
Lecture 1, Development of the Brain (Purves Ch22).............................................................. 3
Lecture 2, Skull, meninges, vasculature & Cranial nerves, brainstem ................................. 15
Lecture 3, Spinal Cord, Somatosensory Systems and Autonomous Nervous System (Purves
Ch9,10,17) ........................................................................................................................... 32
Lecture 4, Cortex, Thalamus and Motor Systems (Purves Ch16,17,27,28) .......................... 52
Lecture 5, Basal Ganglia and Cerebellum (Purves Ch18,19) ............................................... 71
Lecture 6, Limbic System, Hippocampus and Amygdala (Purves Ch30,31) ......................... 96
Synapse Biology ............................................................................................................. 116
Lecture 1, Chemical Synapses ........................................................................................... 116
Lecture 2, PostsynapSc organizaSon ................................................................................ 125
Lecture 4 & 5, FuncSonal Genomics .................................................................................. 142
NeuroPhysiology ............................................................................................................ 155
Lecture 1, Ion Channels (Purves Ch2-4) ............................................................................. 158
Lecture 2, ResSng membrane potenSal (Purves Ch2-4) .................................................... 168
Lecture 3, AcSve properSes of neurons (Purves Ch2-4) .................................................... 177
Lecture 4, AcSon PotenSal PropagaSon (Purves Ch2-4) ................................................... 181
Lecture 5, CorScal FuncSon and Human Mental Ability .................................................... 189
Lecture 6, OptogeneScs .................................................................................................... 197
Lecture 7, SynapSc PlasScity (Purves Chapter 8 & 30) ...................................................... 213
Paper Discussion Nabavi ............................................................................................... 221
Lecture 8, CogniSve Map/ Memories (Purves Chapter 30) ............................................... 230
Lecture 8, CogniSve Map/ Memories (Purves Chapter 30) ............................................... 230
Paper Discussion LiuNature (memory) .......................................................................... 240
Basics in Cell Biology and Neurobiology .......................................................................... 251
Lecture 1, Intracellular Compartments and Transport (EssenSal Cell Biology Ch15) ........ 251
Lecture 2, Intracellular Signaling (EssenSal Cell Biology Ch16/ Purves Ch7) ..................... 264
Lecture 3, Protein Structure and FuncSon (EssenSal Cell Biology Ch4) ............................. 279
Lecture 4, Cytoskeleton (EssenSal Cell Biology Ch17) ....................................................... 293
Lecture 5, Neurotransmi\ers and their Receptors (Purves Ch6) ....................................... 303
, Lecture 6, DNA and Chromosomes (EssenSal Cell Biology Ch5) ........................................ 315
Lecture 7, From DNA to Protein: How Cells Read the Genome (EssenSal Cell Biology Ch7)
.......................................................................................................................................... 323
Lecture 8, Synapses (Purves Ch5) ...................................................................................... 335
Lecture 9, Molecular Memory / SynapSc PlasScity (Purves Ch8) ...................................... 349
Methods and Models in Neuroscience ............................................................................ 358
Lecture 1, C. elegans ......................................................................................................... 359
Lecture 2, Yeast ................................................................................................................. 371
Lecture 3, Drosophila ........................................................................................................ 381
Lecture 4, Mouse ............................................................................................................... 388
,NeuroAnatomy
Lecture 1, Development of the Brain (Purves Ch22)
Some of the exam quesAons will be form the quesAons made by the students
From neural plate to neural tube
The neural plate will form a tube which expands to form the different compartments of the
brain
Neural tube expansion
They fold into each other
, All these folds expand to form the brain as we know it
Embryonic to adult brain
Vesicles are: prosencephalon, mesencephalon and rhombencephalon
Table of Contents
NeuroAnatomy ................................................................................................................... 3
Lecture 1, Development of the Brain (Purves Ch22).............................................................. 3
Lecture 2, Skull, meninges, vasculature & Cranial nerves, brainstem ................................. 15
Lecture 3, Spinal Cord, Somatosensory Systems and Autonomous Nervous System (Purves
Ch9,10,17) ........................................................................................................................... 32
Lecture 4, Cortex, Thalamus and Motor Systems (Purves Ch16,17,27,28) .......................... 52
Lecture 5, Basal Ganglia and Cerebellum (Purves Ch18,19) ............................................... 71
Lecture 6, Limbic System, Hippocampus and Amygdala (Purves Ch30,31) ......................... 96
Synapse Biology ............................................................................................................. 116
Lecture 1, Chemical Synapses ........................................................................................... 116
Lecture 2, PostsynapSc organizaSon ................................................................................ 125
Lecture 4 & 5, FuncSonal Genomics .................................................................................. 142
NeuroPhysiology ............................................................................................................ 155
Lecture 1, Ion Channels (Purves Ch2-4) ............................................................................. 158
Lecture 2, ResSng membrane potenSal (Purves Ch2-4) .................................................... 168
Lecture 3, AcSve properSes of neurons (Purves Ch2-4) .................................................... 177
Lecture 4, AcSon PotenSal PropagaSon (Purves Ch2-4) ................................................... 181
Lecture 5, CorScal FuncSon and Human Mental Ability .................................................... 189
Lecture 6, OptogeneScs .................................................................................................... 197
Lecture 7, SynapSc PlasScity (Purves Chapter 8 & 30) ...................................................... 213
Paper Discussion Nabavi ............................................................................................... 221
Lecture 8, CogniSve Map/ Memories (Purves Chapter 30) ............................................... 230
Lecture 8, CogniSve Map/ Memories (Purves Chapter 30) ............................................... 230
Paper Discussion LiuNature (memory) .......................................................................... 240
Basics in Cell Biology and Neurobiology .......................................................................... 251
Lecture 1, Intracellular Compartments and Transport (EssenSal Cell Biology Ch15) ........ 251
Lecture 2, Intracellular Signaling (EssenSal Cell Biology Ch16/ Purves Ch7) ..................... 264
Lecture 3, Protein Structure and FuncSon (EssenSal Cell Biology Ch4) ............................. 279
Lecture 4, Cytoskeleton (EssenSal Cell Biology Ch17) ....................................................... 293
Lecture 5, Neurotransmi\ers and their Receptors (Purves Ch6) ....................................... 303
, Lecture 6, DNA and Chromosomes (EssenSal Cell Biology Ch5) ........................................ 315
Lecture 7, From DNA to Protein: How Cells Read the Genome (EssenSal Cell Biology Ch7)
.......................................................................................................................................... 323
Lecture 8, Synapses (Purves Ch5) ...................................................................................... 335
Lecture 9, Molecular Memory / SynapSc PlasScity (Purves Ch8) ...................................... 349
Methods and Models in Neuroscience ............................................................................ 358
Lecture 1, C. elegans ......................................................................................................... 359
Lecture 2, Yeast ................................................................................................................. 371
Lecture 3, Drosophila ........................................................................................................ 381
Lecture 4, Mouse ............................................................................................................... 388
,NeuroAnatomy
Lecture 1, Development of the Brain (Purves Ch22)
Some of the exam quesAons will be form the quesAons made by the students
From neural plate to neural tube
The neural plate will form a tube which expands to form the different compartments of the
brain
Neural tube expansion
They fold into each other
, All these folds expand to form the brain as we know it
Embryonic to adult brain
Vesicles are: prosencephalon, mesencephalon and rhombencephalon
