BIOL 5500

thymus - Answer site of t-cell development bone marrow - Answer site of b-cell development and selection secondary lymphoid organs - Answer spleen, lymph nodes, adenoids, tonsil, thoracic duct, appendix, peyer's patch cytokines - Answer molecules secreted by one cell acting on another "hormones" of the immune system effects of cytokines - Answer fever, swelling, recruitment of cells, amplification of immune response chemokines - Answer cytokines that st...

first checkpoint of B cell development - Answer selects for functional heavy chain using the pre-BCR checks for structural integrity of heavy chain second checkpoint of B cell development - Answer selects for functional light chain using the BCR BTK (bruton's tyrosine kinase) - Answer enzyme required for growth and differentiation of pre-B cells important for both checkpoints receptor editing - Answer negative selection process by which the immature B cell continues to ...

primary vs secondary immunodeficiency diseases - Answer primary: inherited defects in components of the immune system secondary: caused by environmental factors such as suppressive drugs or infections Types of primary immunodeficiency - Answer 1. dominant: patents inherit one defective and one normal allele 2. recessive: only manifest in patients who inherit the defective allele from both parents 3. X-linked: caused by recessive defects in genes on the X chromosome defects of IL-2...

Lymphocytes - Answer B cells and T cells; active immunity Myeloids - Answer macrophages, granulocytes, dendritic cells; innate immunity Leukocytes - Answer cells of the immune system (lymphocytes and myeloids) Cytokines/interleukins - Answer communication between leukocytes, amplify immune response Innate immune system - Answer involves macrophages, dendritic cells, etc. no memory, fast reaction Adaptive immune system - Answer involves B cells and T cells, has me...

Where do B and T lymphocytes originate? - Answer bone marrow What characterizes the pre-B-cell stage in B-cell development? - Answer -expression of the pre-BCR -rearrangement of light chain genes -proliferation What characterizes the pro-B-cell stage in B-cell development? - Answer commitment to the B-cell lineage How does allelic exclusion prevent multiple heavy-chain rearrangements from occurring in pre-B cells? - Answer RAG1 and RAG2 are downregulated, and TdT activity ...