Schwartz Biol 5500-Exam 3 Practice
Questions With 100% Correct Answers
Rated A+.
first checkpoint of B cell development - Answer selects for functional heavy chain using the
pre-BCR
checks for structural integrity of heavy chain
second checkpoint of B cell development - Answer selects for functional light chain using the
BCR
BTK (bruton's tyrosine kinase) - Answer enzyme required for growth and differentiation of pre-
B cells
important for both checkpoints
receptor editing - Answer negative selection process by which the immature B cell continues
to rearranges the light chain to make a non-autoreactive BCR
number of rearrangements at the kappa chain - Answer 5
allelic exclusion - Answer only one heavy chain and one light chain are produced in each B-cell
occurs after successful rearrangement at 1 allele
follicular dendritic cells - Answer found in the follicles of lymph nodes
express 2 receptors that bind to intact antigens or pathogens covered in complement
interact with B cells-positive selection and/or activation
non-hematopoietic stromal cells
conventional dendritic cells - Answer take up antigen in peripheral tissues, are activated by
contact with pathogens, and travel to the peripheral lymphoid organs, where they are the most
potent stimulators of T-cell responses
display processed antigens
, B cell fates - Answer plasma or memory cells
somatic hypermutation - Answer mutation that occurs at high frequency in Fab regions in
activated B cells
produces variant antibodies with higher specificity
B cell co-receptor - Answer CR2, CD19, CD81
enhances BCR signaling for complement-labeled antigens
types of B cell activation - Answer T-dependent and T-independent
T-dependent activation - Answer high affinity B cells with class-switched antibodies via
interaction between CD40L on T cells and CD40 on B cells
results in much stronger memory
T-independent activation - Answer results in weak B cell response; short-lived IgM-producing
plasma cells; low affinity antibodies; no class switching
TI-1 activation signal - Answer a combination of BCR and TLR signals activate B cell
TI-2 activation signal - Answer repetitive carbohydrate antigens present at high density on a
pathogen surface, leads to extensive BCR cross-linking
antibody generated from T-independent interaction - Answer IgM
T cell and B cell activation relay - Answer 1. naive B cells search for antigen presented by FDC
and naive T cells search for antigen presented by cDC
2. activated T cells differentiates and proliferates
3. activated B cells move to boundary region of primary follicle
4. activated B cells interact with Tfh cell and differentiate/proliferate into plasma or memory
cells
Questions With 100% Correct Answers
Rated A+.
first checkpoint of B cell development - Answer selects for functional heavy chain using the
pre-BCR
checks for structural integrity of heavy chain
second checkpoint of B cell development - Answer selects for functional light chain using the
BCR
BTK (bruton's tyrosine kinase) - Answer enzyme required for growth and differentiation of pre-
B cells
important for both checkpoints
receptor editing - Answer negative selection process by which the immature B cell continues
to rearranges the light chain to make a non-autoreactive BCR
number of rearrangements at the kappa chain - Answer 5
allelic exclusion - Answer only one heavy chain and one light chain are produced in each B-cell
occurs after successful rearrangement at 1 allele
follicular dendritic cells - Answer found in the follicles of lymph nodes
express 2 receptors that bind to intact antigens or pathogens covered in complement
interact with B cells-positive selection and/or activation
non-hematopoietic stromal cells
conventional dendritic cells - Answer take up antigen in peripheral tissues, are activated by
contact with pathogens, and travel to the peripheral lymphoid organs, where they are the most
potent stimulators of T-cell responses
display processed antigens
, B cell fates - Answer plasma or memory cells
somatic hypermutation - Answer mutation that occurs at high frequency in Fab regions in
activated B cells
produces variant antibodies with higher specificity
B cell co-receptor - Answer CR2, CD19, CD81
enhances BCR signaling for complement-labeled antigens
types of B cell activation - Answer T-dependent and T-independent
T-dependent activation - Answer high affinity B cells with class-switched antibodies via
interaction between CD40L on T cells and CD40 on B cells
results in much stronger memory
T-independent activation - Answer results in weak B cell response; short-lived IgM-producing
plasma cells; low affinity antibodies; no class switching
TI-1 activation signal - Answer a combination of BCR and TLR signals activate B cell
TI-2 activation signal - Answer repetitive carbohydrate antigens present at high density on a
pathogen surface, leads to extensive BCR cross-linking
antibody generated from T-independent interaction - Answer IgM
T cell and B cell activation relay - Answer 1. naive B cells search for antigen presented by FDC
and naive T cells search for antigen presented by cDC
2. activated T cells differentiates and proliferates
3. activated B cells move to boundary region of primary follicle
4. activated B cells interact with Tfh cell and differentiate/proliferate into plasma or memory
cells
