Exam Complete 1-100 Exam Questions Proctored
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What are the contraindications of Pioglitazone? - ANSWER -Avoid in those with
CHF (causes water retention and edema), with or history of bladder cancer, active
liver disease, type I DM, or pregnancy. This drug can increase the risk of
ovulation, bladder cancer, and fractures in women, cause hepatic cancer and affect
cholesterol levels.
What does GLP-1 stand for and list examples? - ANSWER -Glucagon-like peptide
1 receptor agonist.
Dulaglutide (Trulicity), semaglutide (Ozempic), Liraglutide (Victoza).
What does TZD stand for and list examples? - ANSWER -Thiazolidinediones.
Rosiglitzaone (Avandia), Pioglitazone (Actos).
What does DPP4-I stand for and list examples? - ANSWER -Dipeptidyl peptide-4
inhibitors (gliptins).
Sitagliptin (Januvia), saxagliptin (onglyza).
What does SGLT2-I stand for and list examples? - ANSWER -Sodium glucose
cotransporter 2 inhibitors.
Canagliflozin (Invokana), Dapagliflozin (Farixga), Empagliflozin (Jardiance).
Which drug class should be considered for diabetes prior to insulin? - ANSWER -
GLP1 Glucagon like peptide 1 receptor agonist.
How to calculate total daily insulin dose? - ANSWER -Taking the patients weight
in kg and multiplying it by 0.6 units.
, What is the ration of basal insulin to rapid acting insulin in TDD of insulin? -
ANSWER -50/50
What is the carbohydrate to insulin ration when calculating basal insulin? -
ANSWER -1:10
Ex: meal is 60 g of CC, 60/10= 6 units of rapid insulin for coverage.
MOA of Glucagon like peptide 1 receptor agonists (GLP1)? - ANSWER -Slows
gastric emptying, stimulating glucose dependent insulin release, suppressing
postprandial glucagon release and reducing appetite.
MOA of Thiazolidinediones (TZD)? - ANSWER -Decreases insulin resistance and
increases glucose uptake by muscle and adipose tissue and decrease glucose
production by the liver.
MOA of Dipeptidyl peptidase 4 inhibitors (gliptins) (DPP-4I)? - ANSWER -
Enhance the activity of incretins by inhibiting their breakdown by DPP-4 and
increase insulin release, reduce glucagon release, and decrease hepatic glucose
production.
MOA of Sulfonylureas? - ANSWER -Promote insulin secretion by the pancreas;
may also increase tissue response to insulin.
MOA of sodium glucose cotransporter 2 inhibitors (SGLT2I)? - ANSWER -
Increase glucose excretion via the urine inhibiting SGLT-2 in the kidney tubules,
decreasing glucose levels and inducing weight loss by caloric loss through the
urine.
Which diabetic medications come with a concern of hypoglycemia? - ANSWER -
Sulfonylureas, insulin, meglitinides, amylin analogues.
Who is at risk for toxicity of Methylxanthines and why? - ANSWER -Smokers.
Smoking causes increased clearance so if stop smoking levels will rise to toxic
levels.