NSC 830 ADVANCED PHARMACOLOGY
QUESTIONS WITH COMPLETE SOLUTIONS
Narrow Specturm - AnswerTreat limited # of organisms, Less likely to disrupt
normal flora, organism identified.
Broad Specturm - AnswerTreats multiple organisms, more likely to disrupt
normal flora, causative agent unknown.
Why would you select abx? - AnswerIs antimicrobial therapy indicated, make
a clinical diagnosis, collection of specimens for a cx or lab test, make
microbial diagnosis, select drug.
Extended spectrum - Answertreats multiple organisms, more likely to disrupt
normal flora, used when causative organism is unknown.
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, Gram positive - AnswerPurple, thick layer
Example of gram positive - AnswerGroup A beta-strep
Strep PNA
Gram negative - AnswerRed or pink, thin layer
Example of gram negative - AnswerH. influenza
N. Gonoccocus
Atypical Organism - Answercolorless, no layer
Example of Atypical organism - AnswerMacrolides- erythromycins
True or False: Atypical bacteria are resistent to becta-lactum abx -
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, AnswerTrue
Risk factors for Drug Resistant Strep PNA (DRSP) - AnswerRecent abx use
Older >65
Multiple Comorbidtities ( COPD, DM, HF, renal failure)
Daycare worker
Alcoholism
Immunosuppressed (including chronic steroid use >10 mg/day long term).
Treatment for Drug Resistant Strep PNA - AnswerHigh dose amoxicillin 3-
4g/day
Respiratory fluoroquinolones: moxifloxican, gemifloxican, levofloxacin.
Tehlithromycin: use limited due to hepatoxicity
Factors to determine when selecting an abx... - AnswerAllergy history (PCN-
risk of cross allergy with cephalosporins)
Age- (Renal function- neonates and elderly)
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QUESTIONS WITH COMPLETE SOLUTIONS
Narrow Specturm - AnswerTreat limited # of organisms, Less likely to disrupt
normal flora, organism identified.
Broad Specturm - AnswerTreats multiple organisms, more likely to disrupt
normal flora, causative agent unknown.
Why would you select abx? - AnswerIs antimicrobial therapy indicated, make
a clinical diagnosis, collection of specimens for a cx or lab test, make
microbial diagnosis, select drug.
Extended spectrum - Answertreats multiple organisms, more likely to disrupt
normal flora, used when causative organism is unknown.
mailto:https://www.stuvia.com/en-us/user/stuviaguider?page=3&vakfilter=?subject=https://www.stuvia.com/en-
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, Gram positive - AnswerPurple, thick layer
Example of gram positive - AnswerGroup A beta-strep
Strep PNA
Gram negative - AnswerRed or pink, thin layer
Example of gram negative - AnswerH. influenza
N. Gonoccocus
Atypical Organism - Answercolorless, no layer
Example of Atypical organism - AnswerMacrolides- erythromycins
True or False: Atypical bacteria are resistent to becta-lactum abx -
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, AnswerTrue
Risk factors for Drug Resistant Strep PNA (DRSP) - AnswerRecent abx use
Older >65
Multiple Comorbidtities ( COPD, DM, HF, renal failure)
Daycare worker
Alcoholism
Immunosuppressed (including chronic steroid use >10 mg/day long term).
Treatment for Drug Resistant Strep PNA - AnswerHigh dose amoxicillin 3-
4g/day
Respiratory fluoroquinolones: moxifloxican, gemifloxican, levofloxacin.
Tehlithromycin: use limited due to hepatoxicity
Factors to determine when selecting an abx... - AnswerAllergy history (PCN-
risk of cross allergy with cephalosporins)
Age- (Renal function- neonates and elderly)
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