APHON CHEMO COURSE TEST
QUESTIONS WITH CORRECT
ANSWERS
combination chemotherapy - Answer-the use of two or more drugs given simultaneously
or in sequence to overcome drug resistance and achieve the best therapeutic response
within a range of toxicity that can be tolerated by the patient
asparaginases - Answer-major side effects: systemic allergic / anaphylaxis /
hypersensitivity reaction; hyperglycemia; pancreatitis; coagulopathies
bleomycin - Answer-major side effects: pulmonary fibrosis
instruct patients to never scuba dive and avoid use of 100% oxygen for life
busulfan - Answer-major side effects: mucositis, stomatitis, hyperpigmentation,
seizures, and sinusoidal obstruction syndrome (SOS); hepatotoxicity
carboplatin - Answer-major side effects: hypersensitivity, ototoxicity, electrolyte
abnormalities, nephrotoxic and hepatotoxic
carmustine (BCNU) - Answer-major side effects: late pulmonary dysfunction, burning
with peripheral administration, prolong myelosuppression; protect drug from light
cisplatin - Answer-major side effects: nausea / vomiting, anorexia, nephrotoxicity,
ototoxicity, hypomagnesemia
watch urine output (nephrotoxic) and audiograms frequently (ototoxic)
clofarabine - Answer-major side effects: pericardial effusion, tachycardia, hypotension,
edema, cough, respiratory distress, pulmonary edema, capillary leak syndrome (CLS),
systemic inflammatory response syndrome (SIRS), cytokine release syndrome (CRS),
pruritus / dermatitis
corticosteroids - Answer-major side effects: hyperphagia, gastritis, personality changes /
mood swings, immunosuppression, hyperglycemia, GI upset
cyclophosphamide - Answer-major side effects: hemorrhagic cystitis, gondola
dysfunction, amenorrhea, sterility
mesna is often given in combination with this drug
, cytarabine - Answer-major side effects: conjunctivitis with higher doses, nausea /
vomiting, myelosuppression, stomatitis / mucositis, flu-like symptoms with fever
dactinomycin - Answer-major side effects: nausea / vomiting, anorexia, diarrhea, local
ulceration if extravasated, radiation recall reactions, mucositis
give through a CVL; cryotherapy may be used as well (cold therapy)
daunorubicin / doxorubicin - Answer-major side effects: nausea / vomiting, cardiac
dysfunction, cardiomyopathy, myelosuppression
cryotherapy may be used; reddish - orange color of urine, tears, saliva, etc. ; has a
maximum lifetime dose
etoposide - Answer-major side effects: hypotension with rapid infusion, anaphylaxis,
secondary malignancies; hepatotoxic
fludarabine - Answer-major side effects: look for visual changes and neurological
changes
fluorouracil - Answer-major side effects: nausea / vomiting, stomatitis / mucositis,
photosensitivity, hyperpigmentation, rash
give on an empty stomach, monitor stool; cryotherapy used
ifosfamide - Answer-major side effects: gonadal dysfunction, nephrotoxic, hemorrhagic
cycsitis, CNS toxic (neurotoxic)
give with mesna; prehydrate; monitor urine for blood
irinotecan - Answer-major side effects: diarrhea, abdominal cramping
melphalan - Answer-major side effects: stomatitis / mucositis, hyperpigmentation
(melphalan tan)
methotrexate - Answer-major side effects: stomatitis / mucositis, transaminase
elevations, renal tubular necrosis
keep them hydrated! watch urine pH; avoid certain other drugs until this drug has
cleared the body; leucovorin rescue = clear the drug out of body
mitoxantrone - Answer-major side effects: green - blue discoloration of sclera, urine,
and skin; cardiotoxic, mucositis / stomatitis
nelarabine - Answer-major side effects: neurotoxic, confusion, seizures
QUESTIONS WITH CORRECT
ANSWERS
combination chemotherapy - Answer-the use of two or more drugs given simultaneously
or in sequence to overcome drug resistance and achieve the best therapeutic response
within a range of toxicity that can be tolerated by the patient
asparaginases - Answer-major side effects: systemic allergic / anaphylaxis /
hypersensitivity reaction; hyperglycemia; pancreatitis; coagulopathies
bleomycin - Answer-major side effects: pulmonary fibrosis
instruct patients to never scuba dive and avoid use of 100% oxygen for life
busulfan - Answer-major side effects: mucositis, stomatitis, hyperpigmentation,
seizures, and sinusoidal obstruction syndrome (SOS); hepatotoxicity
carboplatin - Answer-major side effects: hypersensitivity, ototoxicity, electrolyte
abnormalities, nephrotoxic and hepatotoxic
carmustine (BCNU) - Answer-major side effects: late pulmonary dysfunction, burning
with peripheral administration, prolong myelosuppression; protect drug from light
cisplatin - Answer-major side effects: nausea / vomiting, anorexia, nephrotoxicity,
ototoxicity, hypomagnesemia
watch urine output (nephrotoxic) and audiograms frequently (ototoxic)
clofarabine - Answer-major side effects: pericardial effusion, tachycardia, hypotension,
edema, cough, respiratory distress, pulmonary edema, capillary leak syndrome (CLS),
systemic inflammatory response syndrome (SIRS), cytokine release syndrome (CRS),
pruritus / dermatitis
corticosteroids - Answer-major side effects: hyperphagia, gastritis, personality changes /
mood swings, immunosuppression, hyperglycemia, GI upset
cyclophosphamide - Answer-major side effects: hemorrhagic cystitis, gondola
dysfunction, amenorrhea, sterility
mesna is often given in combination with this drug
, cytarabine - Answer-major side effects: conjunctivitis with higher doses, nausea /
vomiting, myelosuppression, stomatitis / mucositis, flu-like symptoms with fever
dactinomycin - Answer-major side effects: nausea / vomiting, anorexia, diarrhea, local
ulceration if extravasated, radiation recall reactions, mucositis
give through a CVL; cryotherapy may be used as well (cold therapy)
daunorubicin / doxorubicin - Answer-major side effects: nausea / vomiting, cardiac
dysfunction, cardiomyopathy, myelosuppression
cryotherapy may be used; reddish - orange color of urine, tears, saliva, etc. ; has a
maximum lifetime dose
etoposide - Answer-major side effects: hypotension with rapid infusion, anaphylaxis,
secondary malignancies; hepatotoxic
fludarabine - Answer-major side effects: look for visual changes and neurological
changes
fluorouracil - Answer-major side effects: nausea / vomiting, stomatitis / mucositis,
photosensitivity, hyperpigmentation, rash
give on an empty stomach, monitor stool; cryotherapy used
ifosfamide - Answer-major side effects: gonadal dysfunction, nephrotoxic, hemorrhagic
cycsitis, CNS toxic (neurotoxic)
give with mesna; prehydrate; monitor urine for blood
irinotecan - Answer-major side effects: diarrhea, abdominal cramping
melphalan - Answer-major side effects: stomatitis / mucositis, hyperpigmentation
(melphalan tan)
methotrexate - Answer-major side effects: stomatitis / mucositis, transaminase
elevations, renal tubular necrosis
keep them hydrated! watch urine pH; avoid certain other drugs until this drug has
cleared the body; leucovorin rescue = clear the drug out of body
mitoxantrone - Answer-major side effects: green - blue discoloration of sclera, urine,
and skin; cardiotoxic, mucositis / stomatitis
nelarabine - Answer-major side effects: neurotoxic, confusion, seizures
