EKU PMHNP NSC 830 STUDY GUIDE
Pharmacology - Answer -Study of drugs and drug actions
Pharmacodynamics - Answer -what the drug does in the body-or to the target cell
Receptors - Answer -Protiens located on the surgaces of the cell membranes or w/in
cells. "the lock"
When drug molecules bind with receptors molecules - Answer -the resulting drug-
receptor complex initiates a physio-chemical reaction that stimulates or inhibits it's
normal cell function
Agonist - Answer -drugs that produce effects similar to those produced by naturally
occurring hormones, neurotransmitters, and other natural substances.
Antagonist - Answer -drugs that inhibit cell fx by occupying receptor sites
Therapeutic Index - Answer -The relationship between a drugs desired therapeutic
effects and its adverse effects
Wide therapeutic index - Answer -drug is safe, close monitoring not required
Narrow therapeutic index - Answer -Amount of drug required for therapeutic effect is
not much different that the amount of drug producing a toxic effect. < 2. Close
monitoring needed.
Minimal effective Concentration - Answer -The minimal blood level at which the drug
exerts the desired effect
Area under the curve - Answer -plot of the plasma concentration vs. time after a single
dose of drug is administered
T-max - Answer -time to maximum (peak) drug level after a drug is administered
C-max - Answer -maximum (peak) concentration of a drug after it is administered
First-Pass effect - Answer -Some drugs, when passing from the intestines to the liver,
get metabolized with only part of drug dose reaching systemic circulation for distribution
Bio-availability - Answer -% of drug that reaches systemic circulation after an
administered dose. Used to determine drug dose.
Pharmacology - Answer -Study of drugs and drug actions
Pharmacodynamics - Answer -what the drug does in the body-or to the target cell
Receptors - Answer -Protiens located on the surgaces of the cell membranes or w/in
cells. "the lock"
When drug molecules bind with receptors molecules - Answer -the resulting drug-
receptor complex initiates a physio-chemical reaction that stimulates or inhibits it's
normal cell function
Agonist - Answer -drugs that produce effects similar to those produced by naturally
occurring hormones, neurotransmitters, and other natural substances.
Antagonist - Answer -drugs that inhibit cell fx by occupying receptor sites
Therapeutic Index - Answer -The relationship between a drugs desired therapeutic
effects and its adverse effects
Wide therapeutic index - Answer -drug is safe, close monitoring not required
Narrow therapeutic index - Answer -Amount of drug required for therapeutic effect is
not much different that the amount of drug producing a toxic effect. < 2. Close
monitoring needed.
Minimal effective Concentration - Answer -The minimal blood level at which the drug
exerts the desired effect
Area under the curve - Answer -plot of the plasma concentration vs. time after a single
dose of drug is administered
T-max - Answer -time to maximum (peak) drug level after a drug is administered
C-max - Answer -maximum (peak) concentration of a drug after it is administered
First-Pass effect - Answer -Some drugs, when passing from the intestines to the liver,
get metabolized with only part of drug dose reaching systemic circulation for distribution
Bio-availability - Answer -% of drug that reaches systemic circulation after an
administered dose. Used to determine drug dose.
