NR507 WEEK 1 EXAM QUESTIONS &
VERIFIED ANSWERS RATED 100%
CORRECT
Neutrophils - correct answer ✔✔first responders
Type 1 hypersensitivity REACTION - correct answer ✔✔-IgE mediated
-Ex: Asthma, allergic rhinitis, atopic dermatitis, anaphylactic shock, urticaria, angioedema
LOCAL OR SYSTEMIC
Type 2 (Cytotoxic) hypersensitivity reactions are mediated by - correct answer ✔✔IgG or IgM.
Sensitization - correct answer ✔✔Developing a sensitivity to a substance that initially caused no
allergic reaction.
After the allergen is cleared, the remaining IgE molecules will be bound by mast cells, basophils,
and eosinophils that contain receptors for the IgE molecules.
Immediate degranulation - correct answer ✔✔causes the release of inflammatory mediators
such as histamine, leukotrienes, and prostaglandins that results in vasodilation, bronchial
smooth muscle contraction, and mucus production
Systemic reactions - correct answer ✔✔involve basophil degranulation; they occur throughout
the body, can lead to anaphylactic shock, and can be life-threatening EX. ALLERGIC ASTHMA
,Type II hypersensitivity reaction - correct answer ✔✔-Cytotoxic
-Antibody attacks the antigen leading to lysis (complement mediated)
-IgG & IgM are the principal antibodies involved
-Examples: hemolytic anemia, thrombocytopenia
Hapten - correct answer ✔✔small molecule that has to bind to a larger molecule to form an
antigen
CAN CAUSE AN IMMUNE RESPONSE WHEN IT ATTACHES TO A PROTEIN.
MACROPHAGES ROLE IN TYPE 11 HYPERSENSITIVITY - correct answer ✔✔primary effector cells
of Type II responses
Examples of Type II reactions - correct answer ✔✔drug allergies, hemolytic anemia, blood
transfusion mismatch with resulting transfusion reaction and Rh hemolytic disease.
Type II responses (antibody binds to antigen where? What happens?) - correct answer ✔✔The
cell surface and cause:
The cell to be destroyed by the antibody
Cell destruction through phagocytosis by macrophages
Damage to the cell by neutrophils triggering phagocytosis
Natural killer cells to release toxic substances that destroy the target cell
Malfunction of the cell without destruction
Type III hypersensitivity reaction binds where? - correct answer ✔✔antibody binds to the
antigen in the blood or body fluids and then circulates to the tissue.
, WHAT Reactions are not organ specific and use neutrophils as the primary effector cell - correct
answer ✔✔Type III
What is a complication of type III hypersensitivity? - correct answer ✔✔increase accumulation
of immune-complex deposition (ICD) causes autoimmune diseases, the mononuclear
phagocytes, erythrocytes, and complement system fail to remove immune complexes from the
blood....inflammation occurs. ex. serum sickness
serum sickness - correct answer ✔✔fever, joint pain, non-blanchable rash, swelling to fingers,
knees and feet
type IV hypersensitivity reactions - correct answer ✔✔cell-mediated responses
lymphocytes and macrophages are primary mediators
mediated by T-lymphocytes & MACROPHAGES, DONT use antibodies
EX. contact dermatitis
epidermal reactions characterized by erythema, cellular infiltration and vesicles
humoral immunity - correct answer ✔✔a type of immune response that depends on antibodies
(TYPE 1-3 HYPERSENSITIVITY RX)
Type 1 pathophysiology - correct answer ✔✔Mast cell degranulation results in an inflammatory
response
Type II pathophysiology - correct answer ✔✔1-Complement damages RBC membrane and cells
lyse
5-Autoantibodies specific for thyroid tissue impair receptor for TSH
Type III - Pathophysiology - correct answer ✔✔Complex deposited in small peripheral vessels in
cool temperatures leading to vasoconstriction and blocked circulation
VERIFIED ANSWERS RATED 100%
CORRECT
Neutrophils - correct answer ✔✔first responders
Type 1 hypersensitivity REACTION - correct answer ✔✔-IgE mediated
-Ex: Asthma, allergic rhinitis, atopic dermatitis, anaphylactic shock, urticaria, angioedema
LOCAL OR SYSTEMIC
Type 2 (Cytotoxic) hypersensitivity reactions are mediated by - correct answer ✔✔IgG or IgM.
Sensitization - correct answer ✔✔Developing a sensitivity to a substance that initially caused no
allergic reaction.
After the allergen is cleared, the remaining IgE molecules will be bound by mast cells, basophils,
and eosinophils that contain receptors for the IgE molecules.
Immediate degranulation - correct answer ✔✔causes the release of inflammatory mediators
such as histamine, leukotrienes, and prostaglandins that results in vasodilation, bronchial
smooth muscle contraction, and mucus production
Systemic reactions - correct answer ✔✔involve basophil degranulation; they occur throughout
the body, can lead to anaphylactic shock, and can be life-threatening EX. ALLERGIC ASTHMA
,Type II hypersensitivity reaction - correct answer ✔✔-Cytotoxic
-Antibody attacks the antigen leading to lysis (complement mediated)
-IgG & IgM are the principal antibodies involved
-Examples: hemolytic anemia, thrombocytopenia
Hapten - correct answer ✔✔small molecule that has to bind to a larger molecule to form an
antigen
CAN CAUSE AN IMMUNE RESPONSE WHEN IT ATTACHES TO A PROTEIN.
MACROPHAGES ROLE IN TYPE 11 HYPERSENSITIVITY - correct answer ✔✔primary effector cells
of Type II responses
Examples of Type II reactions - correct answer ✔✔drug allergies, hemolytic anemia, blood
transfusion mismatch with resulting transfusion reaction and Rh hemolytic disease.
Type II responses (antibody binds to antigen where? What happens?) - correct answer ✔✔The
cell surface and cause:
The cell to be destroyed by the antibody
Cell destruction through phagocytosis by macrophages
Damage to the cell by neutrophils triggering phagocytosis
Natural killer cells to release toxic substances that destroy the target cell
Malfunction of the cell without destruction
Type III hypersensitivity reaction binds where? - correct answer ✔✔antibody binds to the
antigen in the blood or body fluids and then circulates to the tissue.
, WHAT Reactions are not organ specific and use neutrophils as the primary effector cell - correct
answer ✔✔Type III
What is a complication of type III hypersensitivity? - correct answer ✔✔increase accumulation
of immune-complex deposition (ICD) causes autoimmune diseases, the mononuclear
phagocytes, erythrocytes, and complement system fail to remove immune complexes from the
blood....inflammation occurs. ex. serum sickness
serum sickness - correct answer ✔✔fever, joint pain, non-blanchable rash, swelling to fingers,
knees and feet
type IV hypersensitivity reactions - correct answer ✔✔cell-mediated responses
lymphocytes and macrophages are primary mediators
mediated by T-lymphocytes & MACROPHAGES, DONT use antibodies
EX. contact dermatitis
epidermal reactions characterized by erythema, cellular infiltration and vesicles
humoral immunity - correct answer ✔✔a type of immune response that depends on antibodies
(TYPE 1-3 HYPERSENSITIVITY RX)
Type 1 pathophysiology - correct answer ✔✔Mast cell degranulation results in an inflammatory
response
Type II pathophysiology - correct answer ✔✔1-Complement damages RBC membrane and cells
lyse
5-Autoantibodies specific for thyroid tissue impair receptor for TSH
Type III - Pathophysiology - correct answer ✔✔Complex deposited in small peripheral vessels in
cool temperatures leading to vasoconstriction and blocked circulation
