NR507 MIDTERM EXAM QUESTIONS &
ANSWERS RATED 100% CORRECT
Innate immunity - correct answer ✔✔the immunity we are born with
Immune response: 3 levels/lines of protection - correct answer ✔✔1st line: physical,
mechanical, & biochemical barriers
2nd line: the inflammatory response
3rd line: lymphocyte production
most important immune defense - correct answer ✔✔intact skin and mucous membranes
(impermeable barrier)
PAMP - correct answer ✔✔pathogen associated molecular pattern
surfaces of bacteria, viruses, and other microbes are covered with many foreign proteins
foreign
DAMP - correct answer ✔✔damage associated molecular pattern
many proteins are released from inside our cells when they are damaged
,foreign
PRR - correct answer ✔✔pattern recognition receptors
surfaces of WBCs contain these receptor sites
-continuously interact with any material they encounter to ID it as "self" or "non-self" (foreign;
PAMP or DAMP)
Chemotaxis - correct answer ✔✔Cell movement that occurs in response to chemical stimulus
Phagocytosis - correct answer ✔✔"cell eating"
1. opsonization and adherence
2. engulfment - WBC surrounds and ingests Ag
3. Fusion of phagosome with lysosome
4. destruction - phagosome digested by lysozyme, H202, acids, and other toxic chemicals inside
the lysosomes
5. egestion
Hypersensitivity Type 1:_____ - correct answer ✔✔Allergic reaction
Hypersensitivity: Type 1
Mediated by ______ - correct answer ✔✔IgE
Hypersensitivity: Type 1
Inflammation due to _____________ - correct answer ✔✔mast cell degranulation
Hypersensitivity: Type 1
, local symptoms - correct answer ✔✔itching, rash
Hypersensitivity: Type 1
systemic symptoms - correct answer ✔✔wheezing
Hypersensitivity: Type 1
most dangerous form - correct answer ✔✔anaphylactic reaction-systemic response-
hypotension, severe bronchoconstriction
Hypersensitivity: Type 1
main treatment ___________ - correct answer ✔✔epinephrine
Hypersensitivity Type 2: _________________ - correct answer ✔✔Cytotoxic reaction; tissue
specific (example: thyroid tissue) hapten causes mediation of IgE or IgM
Hypersensitivity: Type 2
Primary effector cells involved - correct answer ✔✔macrophages
Hypersensitivity: Type 2
can cause ____________ - correct answer ✔✔tissue damage or alter function
Hypersensitivity: Type 2
example of altered function - correct answer ✔✔graves disease (hyperthyroidism)-example of
altering thyroid function, but does not destroy thyroid tissue
Hypersensitivity: Type 2
ANSWERS RATED 100% CORRECT
Innate immunity - correct answer ✔✔the immunity we are born with
Immune response: 3 levels/lines of protection - correct answer ✔✔1st line: physical,
mechanical, & biochemical barriers
2nd line: the inflammatory response
3rd line: lymphocyte production
most important immune defense - correct answer ✔✔intact skin and mucous membranes
(impermeable barrier)
PAMP - correct answer ✔✔pathogen associated molecular pattern
surfaces of bacteria, viruses, and other microbes are covered with many foreign proteins
foreign
DAMP - correct answer ✔✔damage associated molecular pattern
many proteins are released from inside our cells when they are damaged
,foreign
PRR - correct answer ✔✔pattern recognition receptors
surfaces of WBCs contain these receptor sites
-continuously interact with any material they encounter to ID it as "self" or "non-self" (foreign;
PAMP or DAMP)
Chemotaxis - correct answer ✔✔Cell movement that occurs in response to chemical stimulus
Phagocytosis - correct answer ✔✔"cell eating"
1. opsonization and adherence
2. engulfment - WBC surrounds and ingests Ag
3. Fusion of phagosome with lysosome
4. destruction - phagosome digested by lysozyme, H202, acids, and other toxic chemicals inside
the lysosomes
5. egestion
Hypersensitivity Type 1:_____ - correct answer ✔✔Allergic reaction
Hypersensitivity: Type 1
Mediated by ______ - correct answer ✔✔IgE
Hypersensitivity: Type 1
Inflammation due to _____________ - correct answer ✔✔mast cell degranulation
Hypersensitivity: Type 1
, local symptoms - correct answer ✔✔itching, rash
Hypersensitivity: Type 1
systemic symptoms - correct answer ✔✔wheezing
Hypersensitivity: Type 1
most dangerous form - correct answer ✔✔anaphylactic reaction-systemic response-
hypotension, severe bronchoconstriction
Hypersensitivity: Type 1
main treatment ___________ - correct answer ✔✔epinephrine
Hypersensitivity Type 2: _________________ - correct answer ✔✔Cytotoxic reaction; tissue
specific (example: thyroid tissue) hapten causes mediation of IgE or IgM
Hypersensitivity: Type 2
Primary effector cells involved - correct answer ✔✔macrophages
Hypersensitivity: Type 2
can cause ____________ - correct answer ✔✔tissue damage or alter function
Hypersensitivity: Type 2
example of altered function - correct answer ✔✔graves disease (hyperthyroidism)-example of
altering thyroid function, but does not destroy thyroid tissue
Hypersensitivity: Type 2
