Final Exam: NR 567 / NR567 (Latest
Update ) Advanced
Pharmacology for the AGACNP |
Questions & Answers | Grade A |
100% Correct – Chamberlain
Question:
Lithium vs valproic acid for management of bipolar disorder
Answer:
Valproic acid works faster and has better SE profile, but lithium is better at
reducing SI risk and preventing relapse
Question:
lithium MOA
Answer:
Alters cation transport in nerve and muscle. May also influence reuptake of
neurotransmitters.
,Question:
Lithium therapeutic range
Answer:
0.4-1.0 meq/L
Question:
Lithium toxicity range
Answer:
> 1.5 meq/L
Question:
Lithium toxicity manifestations
Answer:
LITHIUM: Lethargy, Increased urination, Tremor, Hypothyroid, Increased
thirst, Upset stomach, Muscle weakness
Question:
Lithium considerations for max effect
Answer:
Anti-manic effects begin 5-7 days after starting, may take up to 2+ weeks for
max effect
,Question:
Lithium - frequency of monitoring
Answer:
Initial: check every 2-3 days
Maintenance: check every 3-6 months
Question:
Lithium lab monitoring
Answer:
Renal function, T3, T4 and TSH before starting and then every 6 months
Question:
Lithium benefits
Answer:
May have neuroprotective features - promote neuronal growth and protect
against atrophy
, Question:
Lithium - Patient teaching
Answer:
Drink 8-12 glasses of fluid per day
Use aspirin for analgesia (avoid other NSAIDs)
Question:
valproic acid MOA
Answer:
increases levels of GABA - inhibitory neurotrans
Question:
valproic acid - monitoring
Answer:
Therapeutic range 50-125 mcg/L. Evaluate every 3-6 months
Evaluate liver function baseline and periodically
Update ) Advanced
Pharmacology for the AGACNP |
Questions & Answers | Grade A |
100% Correct – Chamberlain
Question:
Lithium vs valproic acid for management of bipolar disorder
Answer:
Valproic acid works faster and has better SE profile, but lithium is better at
reducing SI risk and preventing relapse
Question:
lithium MOA
Answer:
Alters cation transport in nerve and muscle. May also influence reuptake of
neurotransmitters.
,Question:
Lithium therapeutic range
Answer:
0.4-1.0 meq/L
Question:
Lithium toxicity range
Answer:
> 1.5 meq/L
Question:
Lithium toxicity manifestations
Answer:
LITHIUM: Lethargy, Increased urination, Tremor, Hypothyroid, Increased
thirst, Upset stomach, Muscle weakness
Question:
Lithium considerations for max effect
Answer:
Anti-manic effects begin 5-7 days after starting, may take up to 2+ weeks for
max effect
,Question:
Lithium - frequency of monitoring
Answer:
Initial: check every 2-3 days
Maintenance: check every 3-6 months
Question:
Lithium lab monitoring
Answer:
Renal function, T3, T4 and TSH before starting and then every 6 months
Question:
Lithium benefits
Answer:
May have neuroprotective features - promote neuronal growth and protect
against atrophy
, Question:
Lithium - Patient teaching
Answer:
Drink 8-12 glasses of fluid per day
Use aspirin for analgesia (avoid other NSAIDs)
Question:
valproic acid MOA
Answer:
increases levels of GABA - inhibitory neurotrans
Question:
valproic acid - monitoring
Answer:
Therapeutic range 50-125 mcg/L. Evaluate every 3-6 months
Evaluate liver function baseline and periodically
