CISSN STUDY GUIDE Questions with Complete Solutions

CISSN STUDY GUIDE Questions with Complete Solutions Explain how carnosine is synthesized within the body a. Carnosine is made in the body from L-histidine and beta-alanine via an energy-dependent reaction catalyzed by carnosine synthetase. b. Found in skeletal muscle, cardiac muscle, brain tissue, kidney, and stomach. c. The highest concentration is found in meats and absorbed in the intestine via peptide transporters. d. Antioxidant activity, (hydroxyl and superoxide radical) and oppose glycation. e. Suppress lipid peroxidation and react with protein carbonyl f. Regulates intracellular calcium and contractility in muscle g. Primarily, carnosine with pH buffering capacity is widely used in the field of sports nutrition. Because the dissociation exponent (pKa) of carnosine is 6.83, it is suggested that carnosine attenuates the reduction in blood pH by a large amount of H+ originating from the dissociation of lactic acid during strenuous exercise, and suppresses a loss of force.