CISSN Exam Review Questions and Answers|Latest Update

CISSN Exam Review Questions and Answers|Latest Update Explain how carnosine is synthesized within the body - carnosine (B-alanyl Histidine) is made in the body from histidine and B-alanine via an energy dependent reaction cartelized by carnosine synthetase -found in skeletal muscle, cardiac muscle, brain, kidney, and stomach -available in meats and absorbed in intestine via peptide transporters - antioxidant activity (hydroxyl and superoxide radical) and oppose glycation - suppress lipid peroxidation and react with protein carbonyl - regulates intracellular calcium and contractility in muscle - primarily, carnosine with pH buffering capacity is widely used in the field of sports nutrition. Because the dissociation exponent (pKa) of carnosine is 6.83, it is suggested that carnosine attenuates the reduction in blood pH by a large amount of H+ originating from the dissociation of lactic acid during strenuous exercise, and suppresses a loss of force