NURSING 220 COMPREHENSIVE EXAM
(2025/2026)
Verified Questions & Answers | 100% Correct | Integrated Nursing Concepts | NCLEX®-RN®
Readiness
Overview
This 2025/2026 validated resource contains 100 comprehensive Nursing 220 exam
questions with 100% verified answers, directly aligned with current nursing curriculum
standards and NCLEX®-RN® test plans. Essential for nursing students synthesizing
medical-surgical, pharmacological, and nursing process concepts for program completion.
Key Features
● 100-Question Comprehensive Exam matching program exit requirements
● Integrated clinical judgment across multiple patient scenarios
● Pharmacology applications with safe medication administration
● Updated 2025/2026 clinical practice guidelines
● Priority-setting frameworks for complex care situations
Content Domains
Domain Questi
ons
Medical-Surgical Nursing 25
Pharmacology & Medication 20
Safety
Nursing Process & Clinical 15
Judgment
Patient Safety & Quality 15
Improvement
Legal/Ethical 10
Considerations
, Professional Practice 10
Health Assessment 5
Answer Format
Correct answers in bold green with:
● Clinical reasoning pathways
● Evidence-based practice citations
● Risk assessment and prevention strategies
● Outcome evaluation criteria
Critical Updates 2025/2026
● New patient safety initiatives
● Revised medication reconciliation protocols
● Updated clinical documentation standards
● Modified quality improvement measures
Medical-Surgical Nursing (Q1–Q25)
1. A client post-op day 1 develops sudden dyspnea, tachycardia, and SpO₂ 88%.
Priority action?
a) Administer pain medication
b) Assess oxygen saturation and apply oxygen
c) Encourage coughing
d) Check glucose
Rationale: Suggests pulmonary embolism; ABCs prioritize oxygenation per ASPAN
2025 guidelines.
2. A client with heart failure reports weight gain of 4 lbs in 2 days. Priority
intervention?
a) Increase fluid intake
b) Notify provider and administer diuretic
c) Encourage ambulation
d) Restrict sodium later
Rationale: >2 lbs/day indicates fluid overload; urgent diuresis per AHA 2025.
, 3. A client with COPD exacerbation has SpO₂ 89%. Target oxygen saturation?
a) >95%
b) 88–92%
c) 92–95%
d) <85%
Rationale: Prevents CO₂ retention; GOLD 2025 guidelines.
4. Post-TKA client has calf tenderness and swelling. Priority?
a) Apply heat
b) Assess for DVT and notify provider
c) Encourage walking
d) Administer acetaminophen
Rationale: High DVT risk; Doppler ultrasound indicated per AAOS 2025.
5. A client with acute pancreatitis reports severe epigastric pain. Expected lab?
a) Amylase 150 U/L
b) Lipase >3x upper limit
c) WBC 8,000
d) Glucose 110 mg/dL
Rationale: Diagnostic criterion; correlates with severity per AGA 2025.
6. A client with atrial fibrillation on warfarin. Therapeutic INR range?
a) 1.5–2.0
b) 2.0–3.0
c) 3.0–4.0
d) <1.5
Rationale: Stroke prevention target; AHA/ACC 2025.
7. A client with sepsis has BP 82/48 mmHg. First fluid?
a) D5W
b) Crystalloid 30 mL/kg bolus
c) Albumin
d) PRBCs
Rationale: Restores perfusion; Surviving Sepsis Campaign 2025.
8. Post-op nausea with opioids. Best management?
a) Increase opioid
b) Ondansetron IV
c) Withhold fluids
d) Encourage eating
Rationale: 5-HT3 antagonist; ASPAN PONV protocol 2025.
9. A client with AKI has K⁺ 6.8 mEq/L. Priority intervention?
a) Sodium polystyrene sulfonate
b) Calcium gluconate IV
(2025/2026)
Verified Questions & Answers | 100% Correct | Integrated Nursing Concepts | NCLEX®-RN®
Readiness
Overview
This 2025/2026 validated resource contains 100 comprehensive Nursing 220 exam
questions with 100% verified answers, directly aligned with current nursing curriculum
standards and NCLEX®-RN® test plans. Essential for nursing students synthesizing
medical-surgical, pharmacological, and nursing process concepts for program completion.
Key Features
● 100-Question Comprehensive Exam matching program exit requirements
● Integrated clinical judgment across multiple patient scenarios
● Pharmacology applications with safe medication administration
● Updated 2025/2026 clinical practice guidelines
● Priority-setting frameworks for complex care situations
Content Domains
Domain Questi
ons
Medical-Surgical Nursing 25
Pharmacology & Medication 20
Safety
Nursing Process & Clinical 15
Judgment
Patient Safety & Quality 15
Improvement
Legal/Ethical 10
Considerations
, Professional Practice 10
Health Assessment 5
Answer Format
Correct answers in bold green with:
● Clinical reasoning pathways
● Evidence-based practice citations
● Risk assessment and prevention strategies
● Outcome evaluation criteria
Critical Updates 2025/2026
● New patient safety initiatives
● Revised medication reconciliation protocols
● Updated clinical documentation standards
● Modified quality improvement measures
Medical-Surgical Nursing (Q1–Q25)
1. A client post-op day 1 develops sudden dyspnea, tachycardia, and SpO₂ 88%.
Priority action?
a) Administer pain medication
b) Assess oxygen saturation and apply oxygen
c) Encourage coughing
d) Check glucose
Rationale: Suggests pulmonary embolism; ABCs prioritize oxygenation per ASPAN
2025 guidelines.
2. A client with heart failure reports weight gain of 4 lbs in 2 days. Priority
intervention?
a) Increase fluid intake
b) Notify provider and administer diuretic
c) Encourage ambulation
d) Restrict sodium later
Rationale: >2 lbs/day indicates fluid overload; urgent diuresis per AHA 2025.
, 3. A client with COPD exacerbation has SpO₂ 89%. Target oxygen saturation?
a) >95%
b) 88–92%
c) 92–95%
d) <85%
Rationale: Prevents CO₂ retention; GOLD 2025 guidelines.
4. Post-TKA client has calf tenderness and swelling. Priority?
a) Apply heat
b) Assess for DVT and notify provider
c) Encourage walking
d) Administer acetaminophen
Rationale: High DVT risk; Doppler ultrasound indicated per AAOS 2025.
5. A client with acute pancreatitis reports severe epigastric pain. Expected lab?
a) Amylase 150 U/L
b) Lipase >3x upper limit
c) WBC 8,000
d) Glucose 110 mg/dL
Rationale: Diagnostic criterion; correlates with severity per AGA 2025.
6. A client with atrial fibrillation on warfarin. Therapeutic INR range?
a) 1.5–2.0
b) 2.0–3.0
c) 3.0–4.0
d) <1.5
Rationale: Stroke prevention target; AHA/ACC 2025.
7. A client with sepsis has BP 82/48 mmHg. First fluid?
a) D5W
b) Crystalloid 30 mL/kg bolus
c) Albumin
d) PRBCs
Rationale: Restores perfusion; Surviving Sepsis Campaign 2025.
8. Post-op nausea with opioids. Best management?
a) Increase opioid
b) Ondansetron IV
c) Withhold fluids
d) Encourage eating
Rationale: 5-HT3 antagonist; ASPAN PONV protocol 2025.
9. A client with AKI has K⁺ 6.8 mEq/L. Priority intervention?
a) Sodium polystyrene sulfonate
b) Calcium gluconate IV
