ONS/ONCC Certification Exams – Complete
Study Set with Solved Questions
ONS/ONCC Certification Study: 100 Q&A
Section 1: Chemotherapy Fundamentals & Safe Handling
1. The primary purpose of using a closed system transfer
device (CSTD) is to:
A) Increase the speed of drug preparation
B) Enhance the solubility of the chemotherapeutic drug
C) Protect healthcare workers from hazardous drug exposure
D) Ensure the sterility of the intravenous line
2. Which personal protective equipment (PPE) is considered
MANDATORY when administering intravenous chemotherapy?
A) Sterile gloves and a mask
B) A single pair of chemotherapy-tested gloves
C) Double gloves, a disposable gown, and eye protection
D) A lead apron for radiation protection
3. If a chemotherapeutic drug extravasates, the first nursing
action should be to:
A) Apply warm compresses to the site
B) Stop the infusion immediately, but leave the catheter in place
,C) Quickly finish administering the remaining drug
D) Remove the IV and apply pressure
4. The vesicant class of chemotherapeutic agents is defined by
their ability to:
A) Cause severe nausea and vomiting
B) Cause tissue blistering and severe local tissue damage
C) Suppress bone marrow function
D) Cause allergic reactions
5. Which of the following is a common example of a vesicant?
A) 5-Fluorouracil (5-FU)
B) Doxorubicin (Adriamycin)
C) Methotrexate
D) Bleomycin
6. The maximum time a nurse should spend in a hazardous
drug spill clean-up without a break is:
A) 15 minutes
B) 20 minutes
C) 30 minutes
D) 60 minutes
7. Which organization sets the standards for safe handling of
hazardous drugs in the US?
A) FDA (Food and Drug Administration)
B) ONS (Oncology Nursing Society)
C) NIOSH (National Institute for Occupational Safety and Health)
, D) CDC (Centers for Disease Control)
8. The process of "priming" an IV tubing set for chemotherapy
administration should be done:
A) At the bedside, just before connecting to the patient
B) Over a sink to discard any excess fluid
C) In the pharmacy or at the preparation site, into a sterile
gauze
D) By the manufacturer before shipment
Section 2: Pharmacology & Drug Administration
9. A patient is receiving Paclitaxel. To prevent a severe
hypersensitivity reaction, the patient will be premedicated
with:
A) Dexamethasone, diphenhydramine, and an H2 blocker
B) Ondansetron and aprepitant
C) Allopurinol and IV fluids
D) Leucovorin and folic acid
10. The chemotherapeutic agent Methotrexate works by
inhibiting the metabolism of:
A) Folic acid
B) Vitamin B12
C) Purines
D) Pyrimidines
Study Set with Solved Questions
ONS/ONCC Certification Study: 100 Q&A
Section 1: Chemotherapy Fundamentals & Safe Handling
1. The primary purpose of using a closed system transfer
device (CSTD) is to:
A) Increase the speed of drug preparation
B) Enhance the solubility of the chemotherapeutic drug
C) Protect healthcare workers from hazardous drug exposure
D) Ensure the sterility of the intravenous line
2. Which personal protective equipment (PPE) is considered
MANDATORY when administering intravenous chemotherapy?
A) Sterile gloves and a mask
B) A single pair of chemotherapy-tested gloves
C) Double gloves, a disposable gown, and eye protection
D) A lead apron for radiation protection
3. If a chemotherapeutic drug extravasates, the first nursing
action should be to:
A) Apply warm compresses to the site
B) Stop the infusion immediately, but leave the catheter in place
,C) Quickly finish administering the remaining drug
D) Remove the IV and apply pressure
4. The vesicant class of chemotherapeutic agents is defined by
their ability to:
A) Cause severe nausea and vomiting
B) Cause tissue blistering and severe local tissue damage
C) Suppress bone marrow function
D) Cause allergic reactions
5. Which of the following is a common example of a vesicant?
A) 5-Fluorouracil (5-FU)
B) Doxorubicin (Adriamycin)
C) Methotrexate
D) Bleomycin
6. The maximum time a nurse should spend in a hazardous
drug spill clean-up without a break is:
A) 15 minutes
B) 20 minutes
C) 30 minutes
D) 60 minutes
7. Which organization sets the standards for safe handling of
hazardous drugs in the US?
A) FDA (Food and Drug Administration)
B) ONS (Oncology Nursing Society)
C) NIOSH (National Institute for Occupational Safety and Health)
, D) CDC (Centers for Disease Control)
8. The process of "priming" an IV tubing set for chemotherapy
administration should be done:
A) At the bedside, just before connecting to the patient
B) Over a sink to discard any excess fluid
C) In the pharmacy or at the preparation site, into a sterile
gauze
D) By the manufacturer before shipment
Section 2: Pharmacology & Drug Administration
9. A patient is receiving Paclitaxel. To prevent a severe
hypersensitivity reaction, the patient will be premedicated
with:
A) Dexamethasone, diphenhydramine, and an H2 blocker
B) Ondansetron and aprepitant
C) Allopurinol and IV fluids
D) Leucovorin and folic acid
10. The chemotherapeutic agent Methotrexate works by
inhibiting the metabolism of:
A) Folic acid
B) Vitamin B12
C) Purines
D) Pyrimidines
