Ciulla: Hematology Exam Questions with Verified Solutions
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1. A. Erythrocyte: 1. What is the first type of cell produced by the developing embryo?
A. Erythrocyte
B. Granulocyte
C. Lymphocyte
D. Thrombocyte
2. C. 50%: 2. What percentage of tissue located in the bone marrow cavities of adults is fat?
A. 10%
B. 25%
C. 50%
D. 75%
3. C. Express the stem cell marker CD 13: 3. Which of the following is not characteristic of pluripotent
hematopoietic stem cells?
A. Possess self-renewal ability
B. Produce progenitor cells committed to a single cell lineage
C. Express the stem cell marker CD 13
D. Are morphologically unrecognizable
4. D. Posterior iliac crest, sternum: 4. In an adult, what are the two best areas for obtaining active bone
marrow by aspiration?
A. Vertebra,tibia
B. Sternum,vertebra
C. Anterior iliac crest, tibia
D. Posterior iliac crest, sternum
5. C. 4:1: 5. What is the normal ratio of myeloid to erythroid precursors in bone marrow (M:E ratio)?
A. 1:1
B. 1:3
C. 4:1
D. 8:1
, Ciulla: Hematology Exam Questions with Verified Solutions
Study online at https://quizlet.com/_i2trli
6. B. Action of majority is lineage restricted: 6. Which of the following does not accurately describe
hematopoietic growth factors?
A. Bind to target cell receptors to express
activity
B. Action of majority is lineage restricted
C. May promote or suppress cell death
D. Can stimulate or inhibit cell
proliferation
7. A. Liver: 7. In the third month of gestation, what is the primary site of hematopoiesis?
A. Liver
B. Marrow of long bones
C. Spleen
D. Yolksac
8. B. Kidney: 8. The mechanism that relays information about tissue oxygen levels to erythropoietin-producing
sites is located in the
A. Brain
B. Kidney
C. Liver
D. Spleen
9. D. Thymus and bone marrow: 9. Antigen-independent lymphopoiesis occurs in primary lymphoid
tissue located in the
A. Liver and kidney
B. Spleen and lymph nodes
C. Peyer's patches and spleen
D. Thymus and bone marrow
10. B. Apoptosis: 10. Programmed cell death is called
A. Necrosis
B. Apoptosis
, Ciulla: Hematology Exam Questions with Verified Solutions
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C. Cellular senescence
D. Terminal differentiation
11. A. Cords: 11. In what area of the bone marrow does hematopoiesis take place?
A. Cords
B. Endosteum
C. Endothelium
D. Sinuses
12. B. Hematopoietic tissue to adipose tissue: 12. Bone marrow cellularity refers to the ratio of
A. Red cell precursors to white cell precursors
B. Hematopoietic tissue to adipose tissue
C. Granulocytic cells to erythrocytic cells
D. Extra vascular tissue to intravascular
tissue
13. C. Monocytes and T lymphocytes: 13. Interleukins and colony stimulating factors are cytokines
produced by
A. B lymphocytes and erythrocytes
B. Erythrocytes and thrombocytes
C. Monocytes and T lymphocytes
D. Neutrophils and monocytes
14. C. 6 L: 14. What is the approximate total blood volume in an adult?
A. 1 L
B. 2 L
C. 6 L
D. 12 L
15. A. Granulocytic, erythrocytic, monocytic,
or megakaryocytic lineages: 15. The myeloid progenitor cell can produce cells committed to
A. Granulocytic, erythrocytic, monocytic,
or megakaryocytic lineages
, Ciulla: Hematology Exam Questions with Verified Solutions
Study online at https://quizlet.com/_i2trli
B. Granulocytic, monocytic, lympho-
cytic, or megakaryocytic lineages
C. Erythrocytic, granulocytic, monocytic,
or lymphocytic lineages
D. Erythrocytic, granulocytic, lympho-
cytic, or megakaryocytic lineages
16. C. Megakaryocytes: 16. The largest hematopoietic cells in normal bone marrow are
A. Osteoblasts
B. Osteoclasts
C. Megakaryocytes
D. Plasma cells
17. D. The presence of 10% myeloblasts on the cell differential count: 17. When
evaluating a bone marrow aspirate smear, which finding is considered abnormal?
A. A predominance of granulocyte
precursors as compared to nucleated
red cells
B. Detection of stainable iron in
macrophages and erythroid precursors
with Prussian blue
C. An average of three megakaryocytes
seen per low power (10X) field
D. The presence of 10% myeloblasts on the cell differential count
18. B. Nucleus to cytoplasm ratio (N:C) decreases: 18. As most blood cell lines mature, which of
the following is characteristic?
A. Cell diameter increases
B. Nucleus to cytoplasm ratio (N:C) decreases
C. Nuclear chromatin becomes less condensed
D. Basophilia of the cytoplasm increases
Study online at https://quizlet.com/_i2trli
1. A. Erythrocyte: 1. What is the first type of cell produced by the developing embryo?
A. Erythrocyte
B. Granulocyte
C. Lymphocyte
D. Thrombocyte
2. C. 50%: 2. What percentage of tissue located in the bone marrow cavities of adults is fat?
A. 10%
B. 25%
C. 50%
D. 75%
3. C. Express the stem cell marker CD 13: 3. Which of the following is not characteristic of pluripotent
hematopoietic stem cells?
A. Possess self-renewal ability
B. Produce progenitor cells committed to a single cell lineage
C. Express the stem cell marker CD 13
D. Are morphologically unrecognizable
4. D. Posterior iliac crest, sternum: 4. In an adult, what are the two best areas for obtaining active bone
marrow by aspiration?
A. Vertebra,tibia
B. Sternum,vertebra
C. Anterior iliac crest, tibia
D. Posterior iliac crest, sternum
5. C. 4:1: 5. What is the normal ratio of myeloid to erythroid precursors in bone marrow (M:E ratio)?
A. 1:1
B. 1:3
C. 4:1
D. 8:1
, Ciulla: Hematology Exam Questions with Verified Solutions
Study online at https://quizlet.com/_i2trli
6. B. Action of majority is lineage restricted: 6. Which of the following does not accurately describe
hematopoietic growth factors?
A. Bind to target cell receptors to express
activity
B. Action of majority is lineage restricted
C. May promote or suppress cell death
D. Can stimulate or inhibit cell
proliferation
7. A. Liver: 7. In the third month of gestation, what is the primary site of hematopoiesis?
A. Liver
B. Marrow of long bones
C. Spleen
D. Yolksac
8. B. Kidney: 8. The mechanism that relays information about tissue oxygen levels to erythropoietin-producing
sites is located in the
A. Brain
B. Kidney
C. Liver
D. Spleen
9. D. Thymus and bone marrow: 9. Antigen-independent lymphopoiesis occurs in primary lymphoid
tissue located in the
A. Liver and kidney
B. Spleen and lymph nodes
C. Peyer's patches and spleen
D. Thymus and bone marrow
10. B. Apoptosis: 10. Programmed cell death is called
A. Necrosis
B. Apoptosis
, Ciulla: Hematology Exam Questions with Verified Solutions
Study online at https://quizlet.com/_i2trli
C. Cellular senescence
D. Terminal differentiation
11. A. Cords: 11. In what area of the bone marrow does hematopoiesis take place?
A. Cords
B. Endosteum
C. Endothelium
D. Sinuses
12. B. Hematopoietic tissue to adipose tissue: 12. Bone marrow cellularity refers to the ratio of
A. Red cell precursors to white cell precursors
B. Hematopoietic tissue to adipose tissue
C. Granulocytic cells to erythrocytic cells
D. Extra vascular tissue to intravascular
tissue
13. C. Monocytes and T lymphocytes: 13. Interleukins and colony stimulating factors are cytokines
produced by
A. B lymphocytes and erythrocytes
B. Erythrocytes and thrombocytes
C. Monocytes and T lymphocytes
D. Neutrophils and monocytes
14. C. 6 L: 14. What is the approximate total blood volume in an adult?
A. 1 L
B. 2 L
C. 6 L
D. 12 L
15. A. Granulocytic, erythrocytic, monocytic,
or megakaryocytic lineages: 15. The myeloid progenitor cell can produce cells committed to
A. Granulocytic, erythrocytic, monocytic,
or megakaryocytic lineages
, Ciulla: Hematology Exam Questions with Verified Solutions
Study online at https://quizlet.com/_i2trli
B. Granulocytic, monocytic, lympho-
cytic, or megakaryocytic lineages
C. Erythrocytic, granulocytic, monocytic,
or lymphocytic lineages
D. Erythrocytic, granulocytic, lympho-
cytic, or megakaryocytic lineages
16. C. Megakaryocytes: 16. The largest hematopoietic cells in normal bone marrow are
A. Osteoblasts
B. Osteoclasts
C. Megakaryocytes
D. Plasma cells
17. D. The presence of 10% myeloblasts on the cell differential count: 17. When
evaluating a bone marrow aspirate smear, which finding is considered abnormal?
A. A predominance of granulocyte
precursors as compared to nucleated
red cells
B. Detection of stainable iron in
macrophages and erythroid precursors
with Prussian blue
C. An average of three megakaryocytes
seen per low power (10X) field
D. The presence of 10% myeloblasts on the cell differential count
18. B. Nucleus to cytoplasm ratio (N:C) decreases: 18. As most blood cell lines mature, which of
the following is characteristic?
A. Cell diameter increases
B. Nucleus to cytoplasm ratio (N:C) decreases
C. Nuclear chromatin becomes less condensed
D. Basophilia of the cytoplasm increases
