Comprehensive Q&A Review (Hematology, Hemostasis, Immunology)

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DLM(ASCP) EXAM ACTUAL EXAM 250 REAL EXAM QUESTIONS AND CORRECT
DETAILED ANSWERS WITH RATIONALES|A+ GRADE 2025/2026 (FINANCIAL
MANAGEMENT, OPERATIONS MANAGEMENT, HUMAN RESOURCE
MANAGEMENT, QUALITY MANAGEMENT)/DLM(ASCP) EXAM
PREPARATION/DLM(ASCP)
Elliptocytes are commonly seen in what condition(s)? - ......ANSWER........hereditary
elliptocytosis, iron deficiency, thalassemia



Eosinophil counts are increased in what conditions? - ......ANSWER........allergies,
parasites



Excess Iron is stored where? What does this cause? - ......ANSWER........tissues and body
organs, hemosiderosis, hemochromatosis



Gaucher's disease is characterized by an increase in what?
- ......ANSWER........glucocerebroside



Ham's/Acid Hemolysis testing measures? - ......ANSWER........complement mediated lysis



Heinz body preps measure? - ......ANSWER........the effect of oxidizing agents on
hemoglobin.



Helmet cells are seen in what condition(s)? - ......ANSWER........hemolytic processes



Hemoglobin A is composed of what types of globin chains? - ......ANSWER........alpha,
delta



Hemoglobin A2 is composed of what types of globin chains? - ......ANSWER........alpha,
beta

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Hemoglobin F is composed of what types of globin chains? - ......ANSWER........alpha,
gamma



Hemoglobin H disease is characterized by the deletion of how many alpha genes?
- ......ANSWER........3



Hemoglobin is measured by its conversion to what? By?
- ......ANSWER........cyanmethemoglobin, potassium cyanide, potassium ferricyanide



Hemoglobinopathies are the result of? - ......ANSWER........structural changes to the globin
chains



Hgb Bart's may be present at birth in individuals suffering from what condition?
- ......ANSWER........hemoglobin H disease



How does EDTA work as an anticoagulant? - ......ANSWER........it chelates Ca++



How does heparin work as an anticoagulant? - ......ANSWER........it is an anti-thrombin
agent



How does the value for hemoglobin compare to the value for the hematocrit?
- ......ANSWER........Hgb X 3 = Hct +/-3%



How does the value for RBCs compare to the value for Hgb? - ......ANSWER........RBC X 3 =
Hgb +/-3%



How is the hematocrit measured using automated methods?
- ......ANSWER........calculated from MCV and RBC

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Howell-Jolly bodies are composed of? - ......ANSWER........DNA



Hyper-segmented neutrophils are associated with what condition(s)?
- ......ANSWER........pernicious anemia



Hypo-segmented neutrophils are associated with what condition(s)?
- ......ANSWER........Pelger Huet, pseudo-Pelger Huet, AML, AIDS



If platelet count seems low what would be the corrective action? - ......ANSWER........check
feather edge for clumping and satellitism. (Is an EDTA related phenomenon) If seen redraw
in Na citrate



In a leukemoid reaction, the LAP score is? - ......ANSWER........increased



In a leukemoid reaction, toxic granulation is? - ......ANSWER........increased



In CML, the LAP score is? - ......ANSWER........decreased



In CML, toxic granulation is? - ......ANSWER........decreased



In individuals with beta thalassemia, what other hemoglobin types are produced to make
up for the lack of beta chain synthesis? What type of hemoglobin is decreased in
production (or absent)? - ......ANSWER........A2 and F are increased; A is decreased or
absent



In relative polycythemia, a decrease in what leads to the relative increase in RBCs?
- ......ANSWER........plasma