NR 507 Advanced Pathophysiology
week 7 Questions & Answers 100%
Correct [Grade A] - Chamberlain
Osteoporosis - correct answer Porous bone- low bone mineral density, impaired
structural integrity of the bone, decreased bone strength, risk of fracture
Most common bone disease in humans - correct answer osteoporosis
Those with lowest BMD at most risk for - correct answer Fracture
What happens with osteoporosis - correct answer Old bone being reabsorbed faster
than new bone is being made causing them to lose density, become thinner and more
porous
Severe or established osteoporosis identified when there has been a - correct answer
Fragility fracture
Most common osteoporotic fracture - correct answer Vertebral fracture
Complication of vertebral fracture - correct answer Deformity, reduced pulmonary
function, and loss of height
Most common method of estimating bone mass - correct answer Dual X-ray
absorptiometry (DXA)
Fracture Risk Assessment Tool (FRAX) - correct answer Incorporates clinical risk
factors with BMD at the femoral neck to predict 10-year probability of a fracture
Osteoporosis X-ray - correct answer Increases radiolucency or bone-by the time
abnormalities defected by X-ray 25-30 % of bone tissue may have been lost
osteopenia - correct answer Bone density score 1.5 and 2.5 standard deviations from
the norm
T score for osteoporosis - correct answer -2.5 or less from normal bone density
Gout - correct answer Inflammatory response to excessive quantities of uric acid in
the blood and other body fluids, including the synovial fluid
Cause of pain in gout - correct answer Elevated uric acid levels lead to formation of
monosodium urate (MSU) crystals in and around joints and eventually deposited in
connective tissues throughout the body-triggers release of chemokines and
, NR 507 Advanced Pathophysiology
week 7 Questions & Answers 100%
Correct [Grade A] - Chamberlain
interleukins—crystallization in synovial fluid causes acute painful inflammation of the
joint which triggers macrophages-prolonged accumulation results in joint damage
gouty arthritis - correct answer Prolonged accumulation of uric acid resulting in joint
damage
degenerative joint disease - correct answer characterized by the wearing away of the
articular cartilage within the joints
osteophytosis - correct answer new bone formation of joint margins
Primary pathogenesis of OA - correct answer Degeneration and eventual loss and
disordered repair of articular cartilage-chondrocytes become damaged earlier in
disease process due to atypical load bearing paired with genetic/epi genetic and
biochemical factors which lead to increased remodeling of articular cartilage and loss
of smooth, frictionless joint -surface areas of cartilage break off and deep layers
develop fissures - cartilage becomes thin and may be absent over some areas leaving
subchondral bone unprotected
HALLMARK of osteoarthritic process - correct answer Loss of proteoglycans from
articular cartilage
Levels of these enzymes are markedly elevated in OA - correct answer Stromelysin
and collagenase enzymes
Without regulatory action of proteoglycan pump - correct answer Cartilage absorbs
too much fluid and becomes less able to withstand the stresses of weight bearing
nitric oxide - correct answer Stimulates apoptosis in chondrocytes
osteomalacia - correct answer Metabolic disease characterized by inadequate and
delayed mineralization of osteoid in mature compact and spongy bone- bone volume
unchanged but replaced bones consist of soft osteoid instead of rigid bone-occurs in
adult bone
Most important factor in development of osteomalacia - correct answer Deficiency of
vitamin d
week 7 Questions & Answers 100%
Correct [Grade A] - Chamberlain
Osteoporosis - correct answer Porous bone- low bone mineral density, impaired
structural integrity of the bone, decreased bone strength, risk of fracture
Most common bone disease in humans - correct answer osteoporosis
Those with lowest BMD at most risk for - correct answer Fracture
What happens with osteoporosis - correct answer Old bone being reabsorbed faster
than new bone is being made causing them to lose density, become thinner and more
porous
Severe or established osteoporosis identified when there has been a - correct answer
Fragility fracture
Most common osteoporotic fracture - correct answer Vertebral fracture
Complication of vertebral fracture - correct answer Deformity, reduced pulmonary
function, and loss of height
Most common method of estimating bone mass - correct answer Dual X-ray
absorptiometry (DXA)
Fracture Risk Assessment Tool (FRAX) - correct answer Incorporates clinical risk
factors with BMD at the femoral neck to predict 10-year probability of a fracture
Osteoporosis X-ray - correct answer Increases radiolucency or bone-by the time
abnormalities defected by X-ray 25-30 % of bone tissue may have been lost
osteopenia - correct answer Bone density score 1.5 and 2.5 standard deviations from
the norm
T score for osteoporosis - correct answer -2.5 or less from normal bone density
Gout - correct answer Inflammatory response to excessive quantities of uric acid in
the blood and other body fluids, including the synovial fluid
Cause of pain in gout - correct answer Elevated uric acid levels lead to formation of
monosodium urate (MSU) crystals in and around joints and eventually deposited in
connective tissues throughout the body-triggers release of chemokines and
, NR 507 Advanced Pathophysiology
week 7 Questions & Answers 100%
Correct [Grade A] - Chamberlain
interleukins—crystallization in synovial fluid causes acute painful inflammation of the
joint which triggers macrophages-prolonged accumulation results in joint damage
gouty arthritis - correct answer Prolonged accumulation of uric acid resulting in joint
damage
degenerative joint disease - correct answer characterized by the wearing away of the
articular cartilage within the joints
osteophytosis - correct answer new bone formation of joint margins
Primary pathogenesis of OA - correct answer Degeneration and eventual loss and
disordered repair of articular cartilage-chondrocytes become damaged earlier in
disease process due to atypical load bearing paired with genetic/epi genetic and
biochemical factors which lead to increased remodeling of articular cartilage and loss
of smooth, frictionless joint -surface areas of cartilage break off and deep layers
develop fissures - cartilage becomes thin and may be absent over some areas leaving
subchondral bone unprotected
HALLMARK of osteoarthritic process - correct answer Loss of proteoglycans from
articular cartilage
Levels of these enzymes are markedly elevated in OA - correct answer Stromelysin
and collagenase enzymes
Without regulatory action of proteoglycan pump - correct answer Cartilage absorbs
too much fluid and becomes less able to withstand the stresses of weight bearing
nitric oxide - correct answer Stimulates apoptosis in chondrocytes
osteomalacia - correct answer Metabolic disease characterized by inadequate and
delayed mineralization of osteoid in mature compact and spongy bone- bone volume
unchanged but replaced bones consist of soft osteoid instead of rigid bone-occurs in
adult bone
Most important factor in development of osteomalacia - correct answer Deficiency of
vitamin d
