TEST BANK FOR PHARMACOLOGY:
A PATIENT-CENTERED NURSING
PROCESS APPROACH 11TH EDITION
LEGAL AND BASIC PRINCIPLES
Pharmacokinetics - CORRECT ANSWER-the process of drug movement
throughout the body necessary to achieve drug action
Absorption - CORRECT ANSWER-the movement of the drug into the
bloodstream after administration
Bioavailability - CORRECT ANSWER-percentage of administered drug
available for activity
First Pass Effect (Metabolism) - CORRECT ANSWER-some drugs are
metabolized to an inactive form and are excreted, thus reducing the
amount of active drug available to exert a pharmacologic effect
Distribution - CORRECT ANSWER-movement of the drug from the
circulation to body tissues
, Distribution is affected by - CORRECT ANSWER-Blood flow to tissues
Faster: heart , liver, kidneys, and brain
Slower: muscle, skin, and fat
blood-brain barrier - CORRECT ANSWER-limits and slows effect
lipid soluble meds can pass
Protein binding of drugs - CORRECT ANSWER-binds with most protein
(albumin)
Drug-Drug interactions - CORRECT ANSWER-2 meds are trying to be
bound one will not be as bound as the other so it will have less effect and
there is a risk of toxicity
Metabolism - CORRECT ANSWER-the process by which the body
chemically changes drugs into a form that can be excreted
P-450 enzyme - CORRECT ANSWER-helps break down the med and
evacuate
Grapefruit juice - CORRECT ANSWER-tastes like crap but also inhibits P-
450
Phenytoin - CORRECT ANSWER-is a P-450 inducer
A PATIENT-CENTERED NURSING
PROCESS APPROACH 11TH EDITION
LEGAL AND BASIC PRINCIPLES
Pharmacokinetics - CORRECT ANSWER-the process of drug movement
throughout the body necessary to achieve drug action
Absorption - CORRECT ANSWER-the movement of the drug into the
bloodstream after administration
Bioavailability - CORRECT ANSWER-percentage of administered drug
available for activity
First Pass Effect (Metabolism) - CORRECT ANSWER-some drugs are
metabolized to an inactive form and are excreted, thus reducing the
amount of active drug available to exert a pharmacologic effect
Distribution - CORRECT ANSWER-movement of the drug from the
circulation to body tissues
, Distribution is affected by - CORRECT ANSWER-Blood flow to tissues
Faster: heart , liver, kidneys, and brain
Slower: muscle, skin, and fat
blood-brain barrier - CORRECT ANSWER-limits and slows effect
lipid soluble meds can pass
Protein binding of drugs - CORRECT ANSWER-binds with most protein
(albumin)
Drug-Drug interactions - CORRECT ANSWER-2 meds are trying to be
bound one will not be as bound as the other so it will have less effect and
there is a risk of toxicity
Metabolism - CORRECT ANSWER-the process by which the body
chemically changes drugs into a form that can be excreted
P-450 enzyme - CORRECT ANSWER-helps break down the med and
evacuate
Grapefruit juice - CORRECT ANSWER-tastes like crap but also inhibits P-
450
Phenytoin - CORRECT ANSWER-is a P-450 inducer
